Feline rhinotracheitis virus: a feline Herpesvirus

Ditchfield, J; Grinyer, I.

doi:10.1016/0042-6822(65)90013-9

Cited by 22 publications

(4 citation statements)

References 5 publications

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“…The majority of the viruses that have been isolated from the cat are picornaviruses (9). The herpesvirus group is represented by feline rhinotrachetitis virus (10,12,14,19,40). Feline ataxia virus and the major feline pathogen, feline panleukopenia virus, are currently considered to be parvoviruses (3, 29-32, 36, 53).…”

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confidence: 99%

Characteristics of a Virus Isolated from a Feline Fibrosarcoma

McKissick

Lamont

1970

J Virol

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A virus was isolated from a radioresistant feline fibrosarcoma. It induced multinucleated giant-cell formation and lysis in a cell line derived from a canine fibrosarcoma, which was used to characterize the virus. End-point titrations in these cells required 28 days. The virus was sensitive to ether and heat and was destroyed at pH 3. Replication was not inhibited by 5-bromodeoxyuridine. Electron microscopy revealed assembly by a budding process from the plasma membrane of infected cells. The average diameter of the virion was 106 nm. Intracisternal particles with an average diameter of 45 nm were present within infected cells. In two instances secondary monolayers of feline renal cells underwent morphological transformation after inoculation of the virus. The two strains of transformed cells are now in continuous culture and do not yield infectious virus. MATERIALS AND METHODS Virus. The pool of virus used in these studies was prepared from the third subpassage of the virus in a cell line derived from a canine fibrosarcoma. Cellculture medium and infected cells were harvested 12 days postinfection. The pool was frozen at-90 C and subsequently thawed, redistributed in portions, refrozen, and maintained in liquid nitrogen vapor. This pool of virus was titrated 27 times over an interval of 27 months. The average titer was 10155 50% tissue culture infectious doses (TCIDso) /ml. The infectivity titer did not decrease during storage. Canine herpesvirus (CHV) was used as a control deoxyribonucleic (DNA) virus in studies of the effect of 5-bromodeoxyuridine on virus replication. CHV was obtained from

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confidence: 99%

Characteristics of a Virus Isolated from a Feline Fibrosarcoma

McKissick

Lamont

1970

J Virol

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“…The designation of "feline viral rhinotracheitis (FVR)" was proposed for the disease [12]. Subsequent works supported Crandell's view that the virus should be classified in the Herpesviridae [5,16] and defined as feline herpesvirus type 1 (FHV-1) [69]. Since the original isolation, FHV-1 has been shown to be the most clinically significant pathogen for respiratory infections in cats [63].…”

Section: Hemagglutinin To Feline Red Blood Cell (Rbc)mentioning

confidence: 82%

“…Sci. 60(8): 881-888, 1998 negative staining of the virions [16,52,54,88] or ultrathin sectioning of FHV-1-infected cells [11,54], mature virus particles are 120-180 nm in diameter, with various morphologies in shapes and sizes of the envelope surrounding the hexagonal outline of the capsid. The genome of FHV-1 consists of approximately 126-134 kbp.…”

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confidence: 99%

Properties and Functions of Feline Herpesvirus Type 1 Glycoproteins.

1998

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ABSTRACT. Feline herpesvirus type 1 (FHV-1) is a causative agent of feline viral rhinotracheitis and belongs to the subfamily Alphaherpesvirinae of the family Herpesviridae. Since first isolated in 1958 by Crandell and Maurer, FHV-1 is distributed worldwide and is the most clinically significant agent for respiratory infections in cats. In this review, we describe the recent findings with properties and functions of FHV-1 glycoproteins, especially hemagglutinins. -KEY WORDS: feline herpesvirus type 1, glycoprotein, hemagglutinin.J. Vet. Med. Sci. 60(8): 881-888, 1998 negative staining of the virions [16,52,54,88] or ultrathin sectioning of FHV-1-infected cells [11,54], mature virus particles are 120-180 nm in diameter, with various morphologies in shapes and sizes of the envelope surrounding the hexagonal outline of the capsid. The genome of FHV-1 consists of approximately 126-134 kbp. It has a G+C content of approximately 50%. The genome is divided into two unique portions, the unique long (U L ) and unique short (U S ) regions, by inverted repeat segments (IR) (Fig. 1) [24,70]. The U L is 99-104 kbp in size and is composed of unique DNA. The adjacent short segment is approximately 27-30 kbp in size and contains a central portion of Us which is approximately 8-9 kbp in size. The Us region is bounded by inverted repeat sequences of 7-11 kbp.We have already introduced review articles on recombinant viral vector vaccines for the veterinary use [97] and molecular interactions between retroviruses and herpesviruses [30]. Therefore, this review mainly focuses on some of the recent developments regarding properties and functions of FHV-1 glycoproteins including hemagglutinin.

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“…(a) FVR virus. FVR virus has been classified as a herpesvirus (Ditchfield & Grinyer, 1965), producing characteristic intranuclear inclusion bodies in infected cells (Crandell & Despeaux, 1959). The virus is fragile, surviving for only up to 18 hours in a moist environment at approximately 15"C, and less than 12 hours at a similar temperature in a dry environment (Povey & Johnson, 1970); it is susceptible to the effects of heat and acid (Miller & Crandell, 1962;Johnson, 1966) and to common disinfectants (e.g.…”

Section: S E C T I O N 1 (1) T H E a G E N T Smentioning

confidence: 99%

Feline viral respiratory disease: a review with particular reference to its epizootiology and control

Gaskell¹,

Wardley²

1978

J of Small Animal Practice

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The two major causes of feline viral respiratory disease are feline viral rhinotracheitis virus and feline calicivirus. This paper reviews the present state of knowledge concerning these viral agents, the clinical syndromes they produce, their maintenance in the cat population including recent developments in the understanding of their carrier states, and finally the methods by which they spread. The second part of the paper attempts to correlate this information in a section which deals with the practical problems of prevention and control; management factors pertinent to the control of respiratory disease and problems of vaccine development and vaccine use are discussed. A short section on treatment is included.

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Feline rhinotracheitis virus: a feline Herpesvirus

Cited by 22 publications

References 5 publications

Characteristics of a Virus Isolated from a Feline Fibrosarcoma

Characteristics of a Virus Isolated from a Feline Fibrosarcoma

Properties and Functions of Feline Herpesvirus Type 1 Glycoproteins.

Feline viral respiratory disease: a review with particular reference to its epizootiology and control

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