2019
DOI: 10.1177/1040638719884950
|View full text |Cite
|
Sign up to set email alerts
|

Feline progressive histiocytosis: a retrospective investigation of 26 cases and preliminary study of Ki67 as a prognostic marker

Abstract: Feline progressive histiocytosis (FPH) is an uncommon and infrequently reported cutaneous histiocytic proliferative disorder, whose clinical presentation is solitary or multiple cutaneous nodules and papules, with late-course internal metastasis. We describe herein the clinical, epidemiologic, histologic, and immunohistochemical features of this entity, and document the outcome of FPH based on a retrospective study of 26 cases. Female and male cats were affected equally. Lesions were evident either as solitary… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

2
22
0

Year Published

2020
2020
2025
2025

Publication Types

Select...
5
1
1

Relationship

0
7

Authors

Journals

citations
Cited by 12 publications
(24 citation statements)
references
References 32 publications
(63 reference statements)
2
22
0
Order By: Relevance
“…In FPH cases, multiple lesions developed in the limb, trunk, and/or the head of middle-aged to elderly cats, which is consistent with previous findings. 1,5,34 Regarding feline HS, there have only been a few case reports. 17,33,35,36,46 The present study is the first to describe the clinical and pathological features of feline HS in a series of cases.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…In FPH cases, multiple lesions developed in the limb, trunk, and/or the head of middle-aged to elderly cats, which is consistent with previous findings. 1,5,34 Regarding feline HS, there have only been a few case reports. 17,33,35,36,46 The present study is the first to describe the clinical and pathological features of feline HS in a series of cases.…”
Section: Discussionmentioning
confidence: 99%
“…In previous studies on FPH, 3/25, 4/5, and 24/26 cases were immunohistochemically positive for E-cadherin; however, CD204 was not examined. 1,5,34 Moreover, the epitheliotropism of neoplastic cells was reported in some E-cadherin-positive cases. Therefore, LC has been suggested as the origin of FPH.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The differential diagnosis for this pathology may indicate Sézary syndrome, a rare end-stage leukaemic variant of cutaneous T-cell lymphoma and cutaneous lymphoid hyperplasia; 40 , 41 disseminated cutaneous mast-cell tumours; 8 feline skin fragility syndrome; 42 cutaneous lymphosarcoma that could present in association with paraneoplastic syndromes; 37 cutaneous lymphocytosis, a rare benign form characterised by proliferation of T and/or B lymphocytes in the dermis and could be fatal when presenting with visceral involvement; 43 , 44 and, finally, feline progressive histiocytosis. 45 …”
Section: Discussionmentioning
confidence: 99%
“…4 The differential diagnosis for this pathology may indicate Sézary syndrome, a rare end-stage leukaemic variant of cutaneous T-cell lymphoma and cutaneous lymphoid hyperplasia; 40,41 disseminated cutaneous mastcell tumours; 8 feline skin fragility syndrome; 42 cutaneous lymphosarcoma that could present in association with paraneoplastic syndromes; 37 cutaneous lymphocytosis, a rare benign form characterised by proliferation of T and/ or B lymphocytes in the dermis and could be fatal when presenting with visceral involvement; 43,44 and, finally, feline progressive histiocytosis. 45 Non-epitheliotropic lymphomas affecting the skin are poorly responsive to chemotherapy or radiation therapy. 11 Treatments described for feline cutaneous lymphoma include the use of corticosteroids alone, chemotherapy (CHOP protocol; vincristine and cyclophosphamide), placental lysate, and intravenous and local administration of fibronectin.…”
Section: Discussionmentioning
confidence: 99%