Feline parathyroid hormone: validation of hormonal assays and dynamics of secretion

Pineda, Carmen; Aguilera–Tejero, Escolástico; Raya, Ana I.; Diez, E.; Rodriguez, Mariano; López, Ignacio

doi:10.1016/j.domaniend.2012.01.003

Cited by 23 publications

(43 citation statements)

References 20 publications

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“…Unfortunately, currently, there are no validated PTH assays for use with feline samples that do not have poor sensitivity . The assay used in this study measures intact PTH and has been validated previously . An assay measuring biologically active “whole” PTH molecule has also been validated, but has not been found to offer advantage over the intact PTH assay …”

Section: Discussionmentioning

confidence: 99%

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium‐Phosphate Homeostasis in Healthy Older Cats

Geddes

Biourge

Chang

et al. 2016

Veterinary Internal Medicne

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BackgroundDietary phosphate and protein restriction decreases plasma PTH and FGF‐23 concentrations and improves survival time in azotemic cats, but has not been examined in cats that are not azotemic.HypothesisFeeding a moderately protein‐ and phosphate‐restricted diet decreases PTH and FGF‐23 in healthy older cats and thereby slows progression to azotemic CKD.AnimalsA total of 54 healthy, client‐owned cats (≥ 9 years).MethodsProspective double‐blinded randomized placebo‐controlled trial. Cats were assigned to test diet (protein 76 g/Mcal and phosphate 1.6 g/Mcal) or control diet (protein 86 g/Mcal and phosphate 2.6 g/Mcal) and monitored for 18 months. Changes in variables over time and effect of diet were assessed by linear mixed models.ResultsA total of 26 cats ate test diet and 28 cats ate control diet. There was a significant effect of diet on urinary fractional excretion of phosphate (P = 0.045), plasma PTH (P = 0.005), and ionized calcium concentrations (P = 0.018), but not plasma phosphate, FGF‐23, or creatinine concentrations. Plasma PTH concentrations did not significantly change in cats fed the test diet (P = 0.62) but increased over time in cats fed the control diet (P = 0.001). There was no significant treatment effect of the test diet on development of azotemic CKD (3 of 26 (12%) test versus 3 of 28 (11%) control, odds ratio 1.09 (95% CI 0.13–8.94), P = 0.92).Conclusions and Clinical ImportanceFeeding a moderately protein‐ and phosphate‐restricted diet has effects on calcium‐phosphate homeostasis in healthy older cats and is well tolerated. This might have an impact on renal function and could be useful in early chronic kidney disease.

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Section: Discussionmentioning

confidence: 99%

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium‐Phosphate Homeostasis in Healthy Older Cats

Geddes

Biourge

Chang

et al. 2016

Veterinary Internal Medicne

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“…Pineda et al (15) were able to measure it in cats with a manual technique, which required 2 successive measurements per sample.…”

Section: Discussionmentioning

confidence: 99%

Reference values of parathyroid hormone and vitamin D Hormone by chemiluminescent automated assay

et al. 2015

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Objective. Provide reference data for parathyroid hormone 1-84 (PTH 1-84) and 25OH Vitamin D (25OH D) using a new technique. Materials and methods. The hormones were evaluated, in serum, using a third generation automated chemiluminescent method for PTH in a group of 60 adult dogs, clinically healthy, grouped according to age in years in GA: 1 to 5, GB: 6 to 10 and GC:>10. Results. Data expressed as average ± DS were for PTH (pg/ml): 9.3±2.3; 12±6.3; 12.2±3.7; and for 25OH D (ng/ml): 84.2±27.8; 68.2±16.0; 63.6±23.1, respectively. The PTH value was significantly greater (p<0.05) in groups B and C in comparison with A, but no significant differences were observed between GB and GC. The 25OH D concentration was significantly less in GB (p<0.05) and in GC (p<0.01) in comparison with GA, showing no differences between GB and GC. A negative correlation between 25OH D and PTH was found (r= -0.28; p=0.015). Conclusions. Data contributed by this study provide reference values for PTH 1-84 and 25OH D, evaluated using a third generation automated chemiluminescent method for PTH in local dogs. The results will facilitate monitoring diseases that alter the metabolism of calcium and phosphorus in dogs.Key Words: Calcium, phosphorus, parathyroid hormone, metabolism, vitamin D (Source: MeSH). RESUMENObjetivo. Aportar datos de referencia, para hormona paratiroidea 1-84 (PTH 1-84) y 25OH Vitamina D (25OH D) con una nueva técnica. Materiales y métodos. Las hormonas fueron valoradas, en suero, por un método quimioluminiscente automatizado, y de tercera generación para la PTH, en una población de 60 perros adultos clínicamente sanos, agrupados según edad en años en GA: 1 a 5, GB: 6 a 10 y GC:>10. Resultados. Los datos expresados como media ± DS fueron para la PTH (pg/ml): 9.3±2.3; 12±6.3; 12.2±3.7; y para la 25OH D (ng/ml): 84.2±27.8; 68.2±16.0; 63.6±23.1, respectivamente. El valor de PTH fue significativamente mayor (p<0.05) en los grupos B y C con respecto al A, pero no se observó diferencia significativa entre GB y GC. La concentración de 25OH D fue significativamente menor en el GB (p<0.05) y en el GC (p<0.01) con respecto al GA, sin haber diferencias entre los GB y GC. Se encontró una correlación negativa entre 25OH D y PTH (r= -0.28; p=0.015). Conclusiones. Los datos aportados en este trabajo permiten disponer de valores de referencia de PTH 1-84 y de 25OH D, valorados por un método quimioluminiscente automatizado y de tercera generación para la PTH, en una población local de perros. Los resultados facilitarán el seguimiento de enfermedades que alteran el metabolismo del calcio y fósforo en perros.Palabras clave: Calcio, fósforo, hormona paratiroidea, metabolismo, vitamina D (Fuente: MeSH).

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“…Vomiting, diarrhea, and/or constipation were observed in 27%, polyuria and/or polydipsia were observed in 24%, urinary signs were seen in 23%, and neurologic signs were observed in 14% (Savary et al, 2000). Thus the differential diagnosis for hypercalcemia in cats is not dramatically different from that in dogs (Mealey et al, 1999;Savary et al, 2000;Pineda et al, 2012). The most common cancers diagnosed included lymphoma and squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Hypercalcemia and Primary Hyperparathyroidism

Feldman¹

2015

Canine and Feline Endocrinology

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Feline parathyroid hormone: validation of hormonal assays and dynamics of secretion

Cited by 23 publications

References 20 publications

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium‐Phosphate Homeostasis in Healthy Older Cats

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium‐Phosphate Homeostasis in Healthy Older Cats

Reference values of parathyroid hormone and vitamin D Hormone by chemiluminescent automated assay

Hypercalcemia and Primary Hyperparathyroidism

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