Feline Mammary Fibroepithelial Hyperplasia: A Clinical Approach

Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment

“…Although the age of the cats with FMFH was statistically similar between G1 and G2, all the cats from G1 aged ⩽1 year and all cats with FMFH >1 year of age were given injectable progestin (G2). The occurrence of FMFH is most common in young cats, 2,21 and the prevalence can be increased if progestin is adopted as a reversible method to prevent undesired pregnancy in early reproductive life. 1,20,[27][28][29] It is plausible that the occurrence of FMFH in adult and geriatric cats from G2 is associated with injectable progestin, as observed in other studies.…”

“…The differences observed between cats from G1 and G2 could be explained by the capability of progestins to stimulate cellular proliferation in mammary tissue, 8,28 as mammary gland is commonly the first tissue to present adverse effects after exposure to progestin. 25,[30][31][32][33] Considering the rapid enlargement of the mammary gland during FMFH, 21 we inferred that the cat owners sought veterinary assistance shortly after clinical signs began, resulting in no significant difference regarding the presence of cutaneous necrosis.…”

“…6,8,13,14,34 Bearing in mind the effectiveness of OVH in the present study, the current availability of antiprogestins and the fact that mastectomy is a very invasive surgery, we think that mastectomy is no longer necessary during treatment of FMFH, which is in agreement with previous reports. 2,21,35 However, it is important to emphasize that proper wound management and permanently wearing the recovery suit are essential to avoid severe infection/sepsis and hemorrhage. 28,33,35,36 OVH resulted in a total FMFH remission rate of 94%, which is similar to previous studies that adopted the early administration of antiprogestin.…”

“…6,18,19 Nowadays, mastectomy should be avoided as antiprogestin drugs are often effective to treat FMFH, although treatment can take as long as 5 weeks and recurrence of FMFH after antiprogestin treatment has been reported. 2,12,20,21 Therefore, the aim of this study was to evaluate the effectiveness of OVH, or its combination with antiprogestin, to treat FMFH in a large set of patients. The influence of injectable progestin on the clinical signs of FMFH and treatment effectiveness was also assessed.…”

“…6,18,19 Nowadays, mastectomy should be avoided as antiprogestin drugs are often effective to treat FMFH, although treatment can take as long as 5 weeks and recurrence of FMFH after antiprogestin treatment has been reported. 2,12,20,21…”