Feline hyperthyroidism: a common disorder with unknown pathogenesis

Kooistra, Hans S.

doi:10.1136/vr.g6597

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Epidemiologic studies looking at risk factors for feline hyperthyroidism commonly conclude that a single factor cannot explain the underlying aetiology of hyperthyroidism 8,11,12,18,19 . Potential environmental exposures to goitrogenic ‘thyroid disruptors’ such as the ubiquitous flame retardant polybrominated diphenyl ethers in household products, soy isoflavones in feline maintenance diets and bisphenol A used to line metal cans have been associated with the development of feline hyperthyroidism 18,20,21 . It has been postulated that these ‘thyroid disruptors’ decrease the effective circulating serum thyroid hormone concentration through thyroid hormone receptor inhibition or inhibition of key enzymes required in the production or activation of thyroid hormones in cats.…”

Section: Pathophysiology Of Feline Hyperthyroidismmentioning

confidence: 99%

“…8,11,12,18,19 Potential environmental exposures to goitrogenic 'thyroid disruptors' such as the ubiquitous flame retardant polybrominated diphenyl ethers in household products, soy isoflavones in feline maintenance diets and bisphenol A used to line metal cans have been associated with the development of feline hyperthyroidism. 18,20,21 It has been postulated that these 'thyroid disruptors' decrease the effective circulating serum thyroid hormone concentration through thyroid hormone receptor inhibition or inhibition of key enzymes required in the production or activation of thyroid hormones in cats. This results in chronic overstimulation of the thyroid tissue by up-regulated TSH secretion as part of the physiologic negative feedback mechanism, with subsequent aberrant hyperplasia of feline thyroid follicular cells.…”

Section: Pathophysiology Of Feline Hyperthyroidismmentioning

confidence: 99%

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Hyperthyroid cats and their kidneys: a literature review

Lacorcia

Johnstone

2022

Aust Veterinary J

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Hyperthyroidism and chronic kidney disease (CKD) are common diseases of geriatric cats, and often occur concurrently. Thus, a thorough understanding of the influence of thyroid function on renal function is of significant value for all feline practitioners. Among other effects, hyperthyroidism causes protein catabolism and increases renal blood flow and glomerular filtration rate (GFR). These effects render traditional renal markers insensitive for the detection of CKD in cats with uncontrolled hyperthyroidism. Furthermore, the development of iatrogenic hypothyroidism with over treatment of hyperthyroidism can be detrimental to renal function and may negatively affect long-term survival. This review discusses important diagnostic considerations of feline hyperthyroidism, as well as key treatment modalities, with an emphasis on the use of radioiodine and the importance of post treatment monitoring of thyroid and renal parameters. In Australia, a common curative treatment for cats with benign hyperthyroidism (i.e. thyroid hyperplasia or adenoma) is a fixed dose of orally administered radioiodine, regardless of the serum total thyroxine concentration at the time of diagnosis. This review discusses the long term outcomes of this standard of care in comparison with current, relevant research literature from around the world. Finally, this review explores the use of symmetric dimethylarginine (SDMA) in assessing renal function before and after treatment in hyperthyroid cats. SDMA correlates well with GFR and creatinine in non-hyperthyroid cats, but our understanding of its performance in hyperthyroid cats remains in its infancy.

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Section: Pathophysiology Of Feline Hyperthyroidismmentioning

confidence: 99%