Feline Herpesvirus Infection in Four Captive Cheetahs (Acinonyx Jubatus) Postvaccination

Pennings, A.M.M.A.; Seeley, Kathryn E.; Mathieu, Amélie; Foust, Abby; Garner, Michael M.; Ramer, Jan

doi:10.1638/2019-0041

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…Furthermore, the relationship between herpetic disease in cheetahs and administration of MLV is poorly understood. A previous investigation of four FHV-1-positive captive cheetahs using PCR-based sequencing techniques failed to establish a relationship between the MLV and herpetic disease due to the highly conserved nature of the FHV-1 genome [10]. However, despite a high degree of homogeneity in FHV-1 isolates, phylogenomic analysis using full viral genome data of this virus from domestic cats led to the discovery that clear clades can be delineated according to geographic host location [15].…”

Section: Introductionmentioning

confidence: 99%

“…Current diagnostic methods include viral isolation, polymerase chain reaction (PCR), and serology. While some treatments have been studied in domestic cats, these are not proven to be effective in other species and are often not practical in wild Felidae [4,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…MLV contain live attenuated viral strains and are selectively used as boosters in breeding female cheetahs at some breeding centers [12]. MLV induce a more robust immune response that is longer lasting than killed vaccines and are thought to improve the maternal transfer of anti-FHV-1 antibodies in nursing cubs, but they have been anecdotally linked to disease development when used in certain cheetahs [3,10,13].…”

Section: Introductionmentioning

confidence: 99%

“…Our objective was to utilize full FHV-1 genome data to investigate possible sources of infection in captive cheetahs, and specifically to assess the use of MLV and spread from domestic cat populations as potential sources. Based on prior evidence [10], we hypothesized that the MLV is capable of causing clinical disease in this species, and that unvaccinated cheetahs are susceptible to infection from FHV-1 spread from domestic cat populations.…”

Section: Introductionmentioning

confidence: 99%

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Full Viral Genome Sequencing and Phylogenomic Analysis of Feline Herpesvirus Type 1 (FHV-1) in Cheetahs (Acinonyx jubatus)

Marino

Mironovich

Ineck

et al. 2021

Viruses

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Feline herpesvirus type 1 (FHV-1) is endemic in captive cheetahs and sporadically causes devastating disease. Modified live vaccines (MLV), intended for use in domestic cats, are used in some captive cheetah populations and have been anecdotally linked to disease in certain subpopulations. Ten FHV-1 isolates from ten captive cheetahs and one isolate from an MLV used to inoculate four of the host animals were analyzed. Viral DNA was extracted for full-genome sequencing by Illumina MiSeq with viral genomes then used for phylogenomic and recombinational analyses. The FHV-1 shed by vaccinated cheetahs were almost identical to the MLV, with few variants among viral genomes. Eight cheetah FHV-1 isolates and the MLV were grouped in a clade along with FHV-1 isolates from domestic cats in the USA. The remaining two cheetah FHV-1 isolates (unknown host vaccine status) were not associated with a clade. The likely ancestral origin of these two isolates involves recombination events between Australian domestic cat and cheetah FHV-1 isolates. Collectively, these data suggest that the MLV is capable of causing clinical disease and viral shedding in some cheetahs and represents evidence of interspecies transmission of virus between domestic and wild cats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Full Viral Genome Sequencing and Phylogenomic Analysis of Feline Herpesvirus Type 1 (FHV-1) in Cheetahs (Acinonyx jubatus)

Marino

Mironovich

Ineck

et al. 2021

Viruses

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“…One of the cases of stomatitis in a cheetah was associated with intranuclear inclusion bodies; this animal also had rhinotracheitis and was confirmed to have feline herpesvirus-1, to which cheetahs may be predisposed. 6 There were multiple limitations of the interpretation of inflammatory lesions in this series. Anatomic location of the lesions within the oral cavity, and/or any associated periodontal disease (eg, dental calculi) were often not specified.…”

Section: Discussionmentioning

confidence: 87%

Oral Lesions in Captive Nondomestic Felids With a Focus on Odontogenic Lesions

Scott¹,

Garner²,

Murphy

et al. 2020

Vet Pathol

Self Cite

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Odontogenic lesions are well described in domestic cats, but published literature describing these lesions in nondomestic felids is limited. This study reports oral lesions in 109 captive, non-domestic felids. Ten cases of odontogenic lesions were diagnosed, including 9 with fibromatous epulis of periodontal ligament origin (FEPLO) and one odontogenic cyst in a cougar. FEPLO was common in lions. FEPLO did not recur after surgical removal in any of the 3 cases for which follow-up information was available. Increased occurrences of oral papillomas in snow leopards and eosinophilic granulomas in tigers were identified, which is consistent with the reported literature. With the exception of oral papillomas in snow leopards and FEPLO in lions, the spectrum of oral lesions in nondomestic felids was similar to what is reported in domestic cats, with squamous cell carcinoma being the most common oral malignancy, and stomatitis/gingivitis/glossitis accounting for approximately one third of all cases. Rare diagnoses with one case each included hemangioma, fibrosarcoma, melanoma, cleft palate, and glossal amyloidosis.

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Postvaccinal Viral Disease Presentation in Two Litters of Cheetahs (Acinonyx Jubatus)

Torres¹,

Hernández²,

Helmick³

2023

Journal of Zoo and Wildlife Medicine

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Feline Herpesvirus Infection in Four Captive Cheetahs (Acinonyx Jubatus) Postvaccination

Cited by 3 publications

References 19 publications

Full Viral Genome Sequencing and Phylogenomic Analysis of Feline Herpesvirus Type 1 (FHV-1) in Cheetahs (Acinonyx jubatus)

Full Viral Genome Sequencing and Phylogenomic Analysis of Feline Herpesvirus Type 1 (FHV-1) in Cheetahs (Acinonyx jubatus)

Oral Lesions in Captive Nondomestic Felids With a Focus on Odontogenic Lesions

Postvaccinal Viral Disease Presentation in Two Litters of Cheetahs (Acinonyx Jubatus)

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