Feline glioma: a retrospective study and review of the literature

Rissi, Daniel R.; Miller, Andrew D.

doi:10.1177/1098612x16689506

Cited by 22 publications

(74 citation statements)

References 40 publications

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“…4,6 Gliomatosis cerebri is characterized by diffuse infiltration of the neuroparenchyma with preservation of the CNS architecture by neoplastic glial cells that are predominantly astrocytic or oligodendrocytic in origin. 11,12,14 In our case, it is likely that the IVDD and extrusion of disk material in conjunction with the leptomeningeal neoplastic cell population both contributed to the neurologic signs and lethargy. The neoplastic population may have partially contributed to the changes described in the white matter and was most likely present before protrusion of the disk material.…”

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confidence: 69%

“…2 Leptomeningeal gliomatosis is characterized by widespread dissemination of neoplastic glial cells throughout the leptomeninges. 2,3,12,13,16 In humans, gliomatosis is divided into primary and secondary forms; the primary form is based on 3 criteria: no attachment of the tumor to the parenchyma, no evidence of intra-axial lesions, and leptomeningeal encapsulation of the tumor. 3,13,16 In secondary gliomatosis, neoplastic cells invade the parenchyma.…”

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confidence: 99%

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Primary leptomeningeal gliomatosis in a domestic shorthaired cat

et al. 2019

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Brief Communication A 15-y-old neutered male domestic shorthaired cat was presented to the Emergency and Critical Care service at the University of Florida Veterinary Hospital (UFVH, Gainesville, FL) after a 16-d history of hindlimb paralysis in conjunction with 1-wk duration of inappetence and lethargy. Prior to admission to UFVH, the patient had been treated by a referring veterinarian with a steroid (identity and dose not provided) and diagnosed with intervertebral disk disease (IVDD) on radiographs (further characterization of the radiographic findings was not provided). Upon admittance to UFVH, the cat was obtunded, hypothermic, hypotensive, and mildly dehydrated. During the physical examination, no spinal trauma or pain was noted on palpation. Bloodwork (complete blood count and serum chemistry) was unremarkable, and overnight intravenous fluids were started. The following morning, the patient had multiple seizures, and euthanasia was elected. The patient was submitted for autopsy ~6 h after euthanasia. Autopsy confirmed IVDD at T1-T2, T9-T10, and L3-L4. At these locations, there was either mild-to-moderate extrusion of degenerate disk material or, in one instance (T1-T2), a firm, smooth nodule (~3 × 5 mm) that mildly protruded into the spinal canal. The main differentials for the clinical signs and spinal cord disease in our case included IVDD, spinal cord neoplasia (lymphoma), and infectious conditions, including feline infectious peritonitis and cryptococcosis. An autopsy was performed with sections of all major organs, as well as the entire brain and spinal cord to the level 822683V DIXXX10.1177/1040638718822683Feline leptomeningeal gliomatosisZoll et al.

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confidence: 69%

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confidence: 99%

Primary leptomeningeal gliomatosis in a domestic shorthaired cat

et al. 2019

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“…[1][2][3][4]16,21,22 Primary brain tumours (eg, meningioma, glioma) are also to be considered as differential diagnoses. 4,12,17,23,24 Meningioma is the most prevalent primary brain tumour in cats (mean age of about 12 years). 4,16,17,[25][26][27] Extracranial extension of a feline meningioma has been described.…”

Section: Discussionmentioning

confidence: 99%

Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat

Santifort¹,

Jurgens

Grinwis

et al. 2018

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity. MRI of the head revealed an expansile soft tissue mass in the caudal nasal passages (both sides but predominantly right-sided) involving the ethmoid bone and extending through the cribriform plate into the cranial vault affecting predominantly the right frontal lobe and temporal lobe. Histopathological examination of the tumour revealed a histiocytic sarcoma.Relevance and novel informationThis is the first report of a cat with clinical signs of temporal lobe epilepsy due to an invasive, histiocytic sarcoma. Histiocytic sarcoma, although rare, should be included in the list of differential diagnoses for soft tissue masses extending through the cribriform plate. Other differential diagnoses are primary nasal neoplasia (eg, adenocarcinoma, squamous cell carcinoma, chondrosarcoma and other types of sarcomas), lymphoma and olfactory neuroblastoma. Temporal lobe epilepsy in cats can be the consequence of primary pathology of temporal lobe structures, or it can be a consequence of pathology with an effect on these structures (eg, mass effect or disruption of interconnecting neuronal pathways).

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“… 1 – 3 Gemistocytic astrocytomas are rarely reported in cats, while anaplastic astrocytomas are even rarer. 3 – 10 There have been scattered reports of glioblastoma (grade IV) and pilocytic astrocytomas (grade I), and a handful of previous reports with astrocytomas of unknown grade. 1 , 11 – 15 There are no reports of surgical management and postoperative recurrence of intracranial feline astrocytoma.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat

Murthy

Liepnieks

Roy

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old Maine Coon cat was presented for acute onset seizures and cerebrothalamic signs. An intracranial mass, suspected to be a meningioma, was diagnosed on MRI and surgically excised. Histopathology appeared consistent with an atypical meningioma. However, following rapid regrowth of the neoplasm, the patient was humanely euthanized 3 months later. On post-mortem histopathology, the neoplasm was diagnosed as a grade III anaplastic gemistocytic astrocytoma. Relevance and novel information Gemistocytic astrocytomas are rare brain tumors in the feline patient. This case represents the first report of a feline grade III anaplastic gemistocytic astrocytoma in the cerebrum of a cat with surgical excision and recurrence. The challenging nature of ante-mortem diagnosis and the guarded prognosis, despite surgical intervention, are presented in this report.

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Feline glioma: a retrospective study and review of the literature

Cited by 22 publications

References 40 publications

Primary leptomeningeal gliomatosis in a domestic shorthaired cat

Primary leptomeningeal gliomatosis in a domestic shorthaired cat

Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat

Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat

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