Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

Assawarachan, Sathidpak Nantasanti; Yodsheewan, Rungrueang; Maneesaay, Phudit; Rattanapinyopituk, Kasem; Chuchalermporn, Piyathip; Kongchun, Atijit; Hakhen, Benjang; Sattasathuchana, Panpicha

doi:10.3390/ani12233278

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…The clinical opinion, however, was that CBD itself was unlikely to have caused the infection directly. Literature suggests that the prevalence of cholangitis in cats worldwide is common and cited as the second most common hepatic disease ( 33 ) across the four distinct forms of the condition: neutrophilic, lymphocytic, destructive, and chronic ( 34 ). The asymptomatic cat from study one was followed beyond study completion, no further complications were noted, and a return to normal range for ALT and AST occurred within 3 weeks.…”

Section: Discussionmentioning

confidence: 99%

Healthy cats tolerate long-term daily feeding of Cannabidiol

Coltherd,

Bednall,

Bakke

et al. 2024

Front. Vet. Sci.

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Cannabidiol (CBD)-containing products are widely commercially available for companion animals, mirroring popularity in human use. Although data on the safety and efficacy of long-term oral supplementation are increasing in dogs, evidence remains lacking in cats. The purpose of these studies was to address gaps in the knowledge around the long-term suitability and tolerance of a tetrahydrocannabinol (THC)-free CBD distillate in clinically healthy cats. The studies were randomized, blinded, and placebo-controlled. The first study supplemented cats with either a placebo oil (n = 10) or with 4 mg/kg body weight (BW) CBD in placebo oil (n = 9) daily, with a meal, for 4 weeks. The concentration of CBD in plasma was measured over 4 h at d0 (first dose) and again at d14 (after 2 weeks of daily dosing). The second study supplemented cats daily with either placebo oil (n = 10) or 4 mg/kg BW CBD in placebo oil (n = 10) for a period of 26 weeks. A comprehensive suite of physiological health measures was performed throughout the study at baseline (week 0) and after 4, 10, 18, and 26 weeks of feeding, followed by a 4-week washout sample (week 30). Postprandial plasma CBD time course data, at both d0 and d14, showed a peak plasma CBD concentration at 2 h after the dose. This peak was 251 (95% CI: 108.7, 393.4) and 431 (95% CI, 288.7, 573.4) ng/mL CBD at d0 and d14, respectively, and the area under the curve concentration was higher by 91.5 (95% CI, 33.1, 149.9) ng-h/mL after 2 weeks of supplementation (p = 0.002). While in the first study the CBD group displayed increased alanine aminotransferase (ALT; 68.7 (95% CI, 43.23, 109.2) U/L) at week 4 compared to the placebo control group [1.44-fold increase (95% CI, 0.813, 2.54)], statistical equivalence (at 2-fold limits) was found for ALT across the duration of the second, long-term study. All other biochemistry and hematology data showed no clinically significant differences between supplement groups. Data presented here suggest that a THC-free, CBD distillate fed at a dose of 4 mg/kg BW was absorbed into plasma and well tolerated by healthy cats when supplemented over a period of 26 weeks.

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Section: Discussionmentioning

confidence: 99%

Healthy cats tolerate long-term daily feeding of Cannabidiol

Coltherd,

Bednall,

Bakke

et al. 2024

Front. Vet. Sci.

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“…Interestingly, complex cystic liver manifestations of liver fluke infection have been described in domestic cat on multiple occasions. [12][13] In patients with relevant epidemiologic exposure, diagnosis of clonorchiasis is most easily achieved by egg identification on stool microscopy, typically detectable four weeks following infection. Urine antigen testing is an emerging diagnostic tool, displaying greater sensitivity than stool microscopy, and has also been proposed as a screening tool in endemic regions.…”

Section: Discussionmentioning

confidence: 99%

Clonorchis sinensis: a mimic of hepatic mucinous cystic neoplasm or just a fluke?

Agrawal,

Williams,

Tran

et al. 2024

Int Surg J

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Liver flukes, endemic in East Asia, are parasites that can infect humans and cause liver and bile duct disease. While most infected individuals are asymptomatic, chronic infection can lead to structural hepatobiliary manifestations including hepatomegaly, intrahepatic bile duct dilatation, epithelial hyperplasia, periductal fibrosis, and potentially cholangiocarcinoma. There are no reports of human cases of liver fluke infection presenting as a hepatic cystic lesion. We present the case of a 52-year-old asymptomatic Chinese immigrant presenting with a suspected mucinous cystic neoplasm of the liver. CT and Ultrasound examinations demonstrated an enlarging complex cyst involving segments II and III. Liver function tests, hydatid serology and tumour markers were normal. He underwent elective laparoscopic left hemi-hepatectomy with liver fluke discovered on histology. Subsequent genetic testing confirmed Clonorchis sinensis infection. The patient made an uneventful recovery from surgery and was treated with anthelminthic therapy. This case highlights the importance of considering liver fluke as a differential diagnosis for hepatic cystic lesions in patients from endemic regions. Appropriate diagnosis could avoid surgery, whilst targeted anthelminthic therapy minimises the risk of chronic infection and associated complications, including cholangiocarcinoma.

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Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

Cited by 2 publications

References 34 publications

Healthy cats tolerate long-term daily feeding of Cannabidiol

Healthy cats tolerate long-term daily feeding of Cannabidiol

Clonorchis sinensis: a mimic of hepatic mucinous cystic neoplasm or just a fluke?

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