Feline Asthma

Trzil, Julie E

doi:10.1016/j.cvsm.2019.10.002

Cited by 33 publications

(22 citation statements)

References 94 publications

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“…The most common presenting complaints for cats with lower respiratory tract disease are dyspnoea, coughing and a fast and/or laboured breathing pattern. Disease conditions that must be excluded by diagnostic testing include pulmonary oedema, verminous pneumonia due to lung and tracheal worms, pleural space disease such as pyothorax, heartworm disease and neoplasia of the lungs or mediastinum [ 33 ]. Auscultation, chest radiography, computed tomography, ultrasonography, bronchoscopy, cytological analysis of BALF specimens after staining with DiffQuik and Gram stains, followed by culture for bacteria and fungi and multiplex qPCR testing for feline respiratory pathogens (including viruses), and allergy testing (serological and intradermal skin testing) are the diagnostic techniques commonly used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…According to a recent review, approximately 1 to 5% of the feline population is affected by chronic lower respiratory tract disease [ 33 ]. Indeed, even higher numbers of cats might be affected as respiratory distress and coughing can be misidentified as ‘a hairball problem’ by owners, so the actual prevalence of airway disease is probably under-estimated [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, even higher numbers of cats might be affected as respiratory distress and coughing can be misidentified as 'a hairball problem' by owners, so the actual prevalence of airway disease is probably under-estimated [34]. Feline bronchial disease can be further classified into four overlapping categories-(i) feline asthma, characterised by eosinophilic airway inflammation associated with increased mucus, bronchospasm, coughing and distal air trapping, (ii) chronic bronchitis, where neutrophils are the predominant cell type within airways and coughing is the main clinical sign [33][34][35][36], (iii) parasitic bronchitis, and (iv) secondary bacterial bronchitis [37]. A key distinguishing feature of asthma is reversible airflow limitation due to functional bronchoconstriction, thought to result from a type I hypersensitivity reaction in airway walls associated with mast cell degranulation [33,34,38].…”

Section: Introductionmentioning

confidence: 99%

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A novel Filobacterium sp can cause chronic bronchitis in cats

Načeradská

Pekova²,

Danesi

et al. 2021

PLoS ONE

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Background Cilia-associated respiratory bacillus (CARB; now known as Filobacterium rodentium gen. nov., sp. nov.) is a primary pathogen of rodents. A CARB-like organism was reported in post-mortem lung samples of cats using light and electron microscopy. Here we explore by molecular procedures if a Filobacterium sp. is a part of the normal feline lower respiratory microbiome and whether it could in some cats contribute to the development of chronic bronchial disease. Methodology A Filobacterium sp. was identified in three Czech cats clinically diagnosed as having chronic neutrophilic bronchitis. Bronchoalveolar lavage fluid (BALF) specimens obtained from these cats were subjected to panbacterial 16S rDNA PCR followed by Sanger sequencing of the V5 to V8 region. After these cats were treated with specific antimicrobials, their clinical signs resolved promptly, without recurrence. Next, BALF specimens from 13 Australian and 11 Italian cats with lower respiratory disease and an additional 16 lung samples of Italian cats who died of various causes were examined using next generation sequencing (NGS). Subsequently, a Filobacterium-specific qPCR assay was developed and used to re-test BALF specimens from the 11 Italian cats and lung tissue homogenates from the additional 16 deceased cats. Principal findings An amplicon of 548 bp with 91.24% sequence agreement with Filobacterium rodentium was obtained from all three patients, suggesting the novel Filobacterium sp. was the cause of their lower respiratory disease. The novel Filobacterium sp., which we propose to call F. felis, was detected in 3/3 Czech cats with chronic neutrophilic bronchitis, 13/13 Australian cats and 6/11 Italian cats with chronic lower respiratory disease, and 14/16 necropsy lung specimens from Italian cats. NGS and qPCR results all showed identical sequences. The Filobacterium sp. was sometimes the preponderant bacterial species in BALF specimens from cats with lower airway disease. There was an association between the presence of large numbers (greater than 105 organisms/mL) of Filobacterium and the presence of neutrophilic and/or histiocytic inflammation, although only a subset of inflammatory BALF specimens had F. felis as the preponderant organism. Conclusion The novel Filobacterium sp. comprises a finite part of the normal feline lower respiratory microbiome. Under certain circumstances it can increase in absolute and relative abundance and give rise to neutrophilic and/or histiocytic bronchitis, bronchiolitis and bronchopneumonia. These findings strongly suggest that F. felis could be an underdiagnosed cause of feline bronchial disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel Filobacterium sp can cause chronic bronchitis in cats

Načeradská

Pekova²,

Danesi

et al. 2021

PLoS ONE

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“…La pregunta inicial incluida en la estrategia de búsqueda para la identificación de los artículos relevantes correspondió a ¿Cuáles son las enfermedades asociadas a bronquiectasia en gatos? El proceso de búsqueda fue implementado el 18 de junio de 2019 y actualizado el 20…”

Section: Estrategia De Búsquedaunclassified

“…Entre las principales enfermedades crónicas de las vías respiratorias inferiores se incluyen el asma felina (FA) y la bronquitis crónica (CB), con una presentación poco común (alrededor del 1%), caso contrario a lo observado con las afecciones de las vías respiratorias superiores (Foster et al, 2003;Trzil, 2019), siendo las poblaciones felinas estresadas y hacinadas las más susceptibles a estas últimas (Azócar et al, 2008; Harvey y Tasker, 2014; Little, 2014; Rodríguez y Guerrero, 2015). El agente etiológico más prevalente es el herpes virus felino 1 (FHV-1), con una presentación del 20% en gatos no vacunados y del 15% en gatos vacunados, que desarrollan signos de la enfermedad felina del tracto respiratorio superior (URTD) (Foster et al, 2003; Minovich y Paludi, 2011; Harvey y Tasker, 2014; Little, 2014; Rodríguez y Guerrero, 2015; Trzil, 2019).…”

Section: Introductionunclassified

Enfermedades asociadas a la bronquiectasia en gatos: una revisión sistemática

Aguilar

Marcela

2020

Rev. investig. vet. Perú

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El presente estudio tuvo como objetivo revisar sistemáticamente la evidencia científica de las enfermedades asociadas a bronquiectasias en gatos, brindando una mejor aproximación a las pruebas diagnósticas y al tratamiento relacionado. Se utilizaron las plataformas de búsqueda OVID®, SciELO Citation Index® y Redalyc®. Se definió una pregunta de investigación, y luego los términos de búsqueda se utilizaron para encontrar artículos relevantes en las bases de datos. Se consideraron solo artículos originales y reportes de casos publicados en revistas indexadas y bajo procesos de revisión por pares, para luego ser filtrados por título, resumen y texto completo. Posteriormente, se realizaron búsquedas en las listas de referencias de los artículos definitivos buscando información adicional (snowballing). Ocho artículos definitivos fueron considerados para la presentación de resultados y discusión (siete publicados en inglés y uno en español, entre 1993 y 2019). A partir de la información colectada de los ocho estudios se puede inferir que la respuesta al tratamiento depende de la enfermedad de base, pero que al presentarse un proceso de mayor cronicidad es difícil que el paciente responda al protocolo de manejo, ya que la bronquiectasia no tiene cura, y que solo se logra, a partir del tratamiento, retrasar su progresión.

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Lower Airway Disease

Johnson¹,

King²

2022

Feline Emergency and Critical Care Medicine

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Feline Asthma

Cited by 33 publications

References 94 publications

A novel Filobacterium sp can cause chronic bronchitis in cats

A novel Filobacterium sp can cause chronic bronchitis in cats

Enfermedades asociadas a la bronquiectasia en gatos: una revisión sistemática

Lower Airway Disease

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