Feline anaplastic oligodendroglioma: long-term remission through radiation therapy and chemotherapy

Abstract

A 10-year-old spayed female Abyssinian cat was presented with cluster limbic focal seizures with secondary generalisation. From magnetic resonance imaging (MRI) findings, the cat was diagnosed clinically as having a glioma in the left piriform lobe, and hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the tumour size had reduced significantly at 4 months after RT, recurrence was observed at 11 months after RT. Additional RT was performed and was effective; however, recurrence was observed at 11 months after the additional RT. Chemotherapy was started using nimustine (ACNU; 30 mg/m(2), every 6 weeks). Tumour regression was confirmed by follow-up MRIs from 2 to 5 months after starting chemotherapy. Four years and 2 months after the first presentation the cat died as a result of tumour lysis syndrome following treatment of a high-grade lymphoma. Histopathological diagnosis of the brain tumour confirmed anaplastic oligodendroglioma.

Radiation therapy for intracranial tumours in cats with neurological signs

“…For cats with inoperable tumors however, literature findings are scarce and limited to cases of pituitary neoplasia and a case report of a cat with oligodendroglioma treated with radiation therapy. [10][11][12][13]20 Surprisingly, amelioration of neurologic symptoms was rapid and often complete in most cats and survival times increased from a median of 1.1-1.7 months if treated with corticosteroids only 1 to a range of 5.5-20.5 months after radiation. [10][11][12][13] These results are difficult to compare to our findings, as in the cats treated for pituitary tumors only 38.9% had neurologic symptoms and most of them were treated because of pituitary-dependent endocrine disease.…”

A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration

“…Therefore, we also started the first dose at the same dose based on the previous report (Tamura et al, 2013). However, unlike previous reports, the dose interval was every 3 weeks because we wanted to increase drug intensity (Tamura et al, 2013).…”

“…In the future, based on the previous case report of nimustine use in a cat (Tamura et al, 2013) and the dose adjustments that needed to be made for the cat in our study, it is required to do a phase I evaluation of nimustine in cats to identify the appropriate dose prior to treating a bunch of cats with LGL lymphoma with nimustine. Moreover, data accumulation of feline LGL lymphomas cases treated by nimustine with and without complete resection is expected.…”

“…These cytologic findings were suggestive of LGL lymphoma by a clinical pathologist with diplomate of the ACVP (Figure 2). was only one information of its use in cats (Tamura et al, 2013).…”

LGI Proteins and Epilepsy in Human and Animals

“…Behavioral changes also may occur. The etiology is usually undetermined, but neoplastic and vascular causes were identified or suspected in some cases . In many cats, acute cluster seizure episodes are observed, resembling LE in humans …”