Fel d I allergen distribution in cat fur and skin

Charpin, Colette; Mata, Paulina; Charpin, D.; Lavaut, Marie‐Noëlle; Allasia, Claude; Vervloët, D.

doi:10.1016/0091-6749(91)90303-6

Cited by 94 publications

(55 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extracts prepared from cat hair and dander, skin, saliva, serum and urine contain allergens [11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. …”

Section: Allergen Sources Allergensmentioning

confidence: 99%

See 1 more Smart Citation

Allergy to Mammalian Proteins: At the Borderline between Foreign and Self?

Spitzauer

1999

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Atopic individuals are characterized by their genetically determined tendency to mount IgE antibody responses against otherwise harmless antigens. Many of the environmental allergens (e. g., plant–, insect–, mould–derived allergens) are recognized as foreign intruders by the immune system. However, a substantial proportion of atopic individuals mount IgE responses to allergens of mammalian origin and, as recently reported, certain of them even react with human proteins (i. e., autoallergens). Through the application of molecular biological techniques for allergen characterization, the molecular nature and biological function of an increasing number of mammalian allergens have been revealed. This review provides a summary of well characterized mammalian allergens derived from hair/dander, saliva, serum and urine of animals (cat, dog, rodents, cow, horse) as well as of some recently characterized autoallergens. In addition, mammalian allergens were grouped in protein families with similar sequences and/or biological functions. The importance of cross–reactivities is exemplified for albumins which represent abundant mammalian serum proteins and highly cross–reactive allergens. Finally, possible advantages of using recombinant animal allergens for novel forms of component–resolved diagnosis and treatment of allergies to mammalian proteins are described.

show abstract

“…Extracts prepared from cat hair and dander, skin, saliva, serum and urine contain allergens [11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. …”

Section: Allergen Sources Allergensmentioning

confidence: 99%

“…Fel d 1 is present in hair, skin and salivary glands of cats [18, 19, 21, 25, 26]. Fel d 1 is a heterodimer with a molecular weight (MW) of 35–39 kD [27, 28, 29].…”

Section: Allergen Sources Allergensmentioning

confidence: 99%

Allergy to Mammalian Proteins: At the Borderline between Foreign and Self?

Spitzauer

1999

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Fel d I) is found mainly in the sebaceous glands of the skin, but also in the salivary glands [14][15][16]. Fel d I is a tetrameric polypeptide,…”

Section: Cat Allergensmentioning

confidence: 99%

From allergen sources to reduction of allergen exposure

Bessot

Blay²,

Pauli³

1994

Eur Respir J

View full text Add to dashboard Cite

F Fr ro om m a al ll le er rg ge en n s so ou ur rc ce es s t to o r re ed du uc ct ti io on n o of f a al ll le er rg ge en n e ex xp po os su ur re e J.C. Bessot, F. de Blay, G. PauliFrom allergen sources to reduction of allergen exposure. J.C. Bessot, F. de Blay, G. Pauli. ERJ Journals Ltd. 1994. ABSTRACT: Allergen exposure plays a major role in the development of sensitization, inflammation and symptomatic asthma. The development of new means of detecting allergens has enabled the evaluation of the effect of a reduction in allergen exposure to be better assessed. In order to prevent allergen exposure it is necessary to determine the allergen sources and reservoirs to which avoidance measures should be directed. The allergen sources and reservoirs of mite, cat, dog, cockroach, rodent, mould and pollen allergens are briefly reviewed. The relationships between allergen exposure, sensitization, nonspecific bronchial hyperreactivity and asthma symptoms are discussed. Recognition of the risks, environmental control, and reduction in allergen loads should be among the objectives of asthma management.

show abstract

“…Fel d 1 elicits IgE responses in 90 -95% of patients with cat allergy (3) and accounts for 60 -90% of the total allergenic activity in cat dander (4). The allergen is produced by sebaceous glands and squamous epithelial cells and is transferred to the pelt by licking and grooming (5)(6)(7). Fel d 1 is also present in the salivary, perianal, and lachrymal glands (8,9).…”

mentioning

confidence: 99%