Fekrynol and its acetate fromFerula krylovii

Coumarins

“…~~* ~~ Under strongly basic conditions the main product is the methoxy acid (54) while under very mild conditions the fivemembered ring may be opened and closed to give either micromelin or its C-4' epimer, isomicromelin. Three dihydromicromelin derivatives have been extracted from Micromelum minutum, dihydromelin A (55) and dihydromelin B (56), isolated as a mixture of hemiacetals, and acetyldihydromelin A (57), hydrolysis of which gives the hemiacetal r n i x t ~r e . ~' Four 102 On the other hand, tortuosinin, the angelate of racemic marmesin has been found in Seseli tortuosum where it occurs with tortuosinol (65), the senecioate of prandi01.…”

Sesquiterpenes and Sesquiterpene Derivatives from Ferula: Their Chemical Structures, Biosynthetic Pathways, and Biological Properties

“…Due to the presence of multiple substituent sites and substituents, the structures of sesquiterpenes are diverse. Here, sesquiterpenes with medicinal or potential medicinal prospects are summarized, including 88 daucane-type sesquiterpenes (1-88), 27 guaiane-type sesquiterpenes (89-115), 13 humulane-type sesquiterpenes (116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128), 11 eudesmane-type sesquiterpenes (129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139), 3 germacrane-type sesquiterpenes (140)(141)(142), 1 elemane-type sesquiterpene (143), and 6 other types of sesquiterpenes (144)(145)(146)(147)(148)(149). The names and sources of compounds 1-149 are listed in Table 1, and their chemical structures are shown in Figure 2.…”

Terpenoid Coumarins of the Genus Ferula

“…67 Fekrynol (37) has been shown to be the corresponding primary alcohol. 71 Farnesiferol B (18) has two isomers lehmferin (19) which was isolated from F. lehmanni 55 and assafoetidin (20) from F. assafoetida. 56 The configuration at C-3 for assafoetidin (20) was not detected, may be identical with lehmferin (19) or may be the 3-epimer.…”