FeII4L₄ tetrahedron binds and aggregates DNA G-quadruplexes

Abstract

Since the discovery of the G-quadruplex (G4) structure in telomeres in 1980s, studies have established the role it plays in various biological processes. Here we report binding between DNA G4...

The Biologically Inspired Abilities of Metallosupramolecular Architectures

“…In addition to these Fe(II) cage systems binding small biomolecules within their cavities they have also been shown to interact with larger biomolecules such as DNA and proteins. Nitschke, Keyers and co‐workers showed that a water soluble Fe II 4 L 4 tetrahedral cage can bind and aggregate G‐quadruplex DNA [44] . Similar binding and/or aggregation of various different DNA, RNA and peptide constructs has also been observed with smaller Fe(II), Ni(II), and Co(III) M 2 L 3 MSAs [45]…”

“…Nitschke, Keyers and co-workers showed that a water soluble Fe II 4 L 4 tetrahedral cage can bind and aggregate G-quadruplex DNA. [44] Similar binding and/or aggregation of various different Aston is completing a Master's degree at the University of Otago under the supervision of Professor James Crowley, working on heterometallic low-symmetry cages. He is interested in selfassembly and molecular recognition.…”

Accurate Matching of a Secondary Amino-Functionality Metal–Organic Cage for Selective Recognition and Supramolecular Binding during Photoinduced Hydrogen Evolution

“…15 As we all know, the double-helix structures of DNA molecules in living organisms are also formed by the perfect matching of hydrogen bonds between base units. 16 This stable binding mode provides inspiration to design supramolecular interactions between host and guest molecules. Therefore, the introduction of multifarious functionality groups as hydrogen donors modified on the organic linker and thus into the host cages as interaction sites is a feasible approach to enhance the binding ability toward specific guests with complementary groups.…”

“…Hydrogen bonds, considered the key and predominant weak interactions, widely exist in biological and chemical systems and also play a significant role in supramolecular assembly . As we all know, the double-helix structures of DNA molecules in living organisms are also formed by the perfect matching of hydrogen bonds between base units . This stable binding mode provides inspiration to design supramolecular interactions between host and guest molecules.…”

Complementarity and Preorganisation in the Assembly of Heterometallic–Organic Cages via the Metalloligand Approach—Recent Advances

“…Many promising applications for individual cages have now been investigated [34][35][36][37]. These include applications for sequestering a wide range of both ions and molecules [38][39][40][41]; for molecule and ion sensing [23,[42][43][44][45][46][47][48][49][50][51][52][53][54][55]; for the stabilisation of reactive species [56,57]; for catalysis where the cage acts as a "reaction vessel" in which, for example, the proximity of the reactants (amongst other influences) act as a driver for promoting enhanced reaction rates [58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75]; as well as for use in biochemical applications [76,77] that include MRI imaging [78], photodynamic therapy …”