Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway

Li, Hongbo; Wang, Zhenkai; Zhang, Jie; Wang, Youlei; Chen, Yu; Zhang, Jinjin; Song, Xiaodong; Lv, Changjun

doi:10.1186/s12906-018-2297-3

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…Preclinical studies in fibrotic animal models have provided important information on novel immune-based therapeutic strategies by targeting different immune cells. Moreover, the molecular insights into fibrogenesis have suggested clinical therapeutic potential by targeting key molecular components, including PI3K/mTOR and JAK-STAT pathways [ 183 , 184 , 185 , 186 ]. Future controlled clinical trials are essential to evaluate the safety and efficacy of potential therapies in patients with fibrotic diseases.…”

Section: Current Progress On Immune-based Anti-fibrotic Therapiesmentioning

confidence: 99%

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Huang

Peng

Xiao

et al. 2020

IJMS

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Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.

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Section: Current Progress On Immune-based Anti-fibrotic Therapiesmentioning

confidence: 99%

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Huang

Peng

Xiao

et al. 2020

IJMS

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“…Feifukang (FFK) treatment significantly reduced the BLM-induced increase in hydroxyproline content, collagen I, and a-SMA expression. Moreover, FEK regulates JAK-STAT signaling via the phosphorylation of Smad3, STAT3, and JAK1 [ 218 ].…”

Section: Natural Products Against Pulmonary Fibrosis With Specific Me...mentioning

confidence: 99%

Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis

Hasan

Paul

et al. 2022

Molecules

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Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of mortality. The potential factors causing PF include viral infections, radiation exposure, and toxic airborne chemicals. Idiopathic PF (IPF) is related to pneumonia affecting the elderly and is characterized by recurring scar formation in the lungs. An impaired wound healing process, defined by the dysregulated aggregation of extracellular matrix components, triggers fibrotic scar formation in the lungs. The potential pathogenesis includes oxidative stress, altered cell signaling, inflammation, etc. Nintedanib and pirfenidone have been approved with a conditional endorsement for the management of IPF. In addition, natural product-based treatment strategies have shown promising results in treating PF. In this study, we reviewed the recently published literature and discussed the potential uses of natural products, classified into three types—isolated active compounds, crude extracts of plants, and traditional medicine, consisting of mixtures of different plant products—in treating PF. These natural products are promising in the treatment of PF via inhibiting inflammation, oxidative stress, and endothelial mesenchymal transition, as well as affecting TGF-β-mediated cell signaling, etc. Based on the current review, we have revealed the signaling mechanisms of PF pathogenesis and the potential opportunities offered by natural product-based medicine in treating PF.

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“…Feifukang (FFK) is a pulmonary rehabilitation mixture comprising eight herbs for protecting lung function: Astragalus membranaceus, Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Panax notoginseng, Bulbus fritillariae thunbergii, Rhizoma anemarrhenae, and Glycyrrhiza uralensis (104,105). Li et al (105) have evaluated anti-pulmonary fibrosis effect of FFK in a bleomycin (BLM)-induced pulmonary fibrosis mouse model and explored targets of FFK by analyzing transcriptome data of FFK-treated mice. FFK has potential antifibrotic effects by significantly reducing collagen fiber formation in BLM-induced lung fibrosis.…”

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

Systems pharmacology approaches in herbal medicine research: a brief review

Lee¹,

Shin²,

Park³

et al. 2022

BMB Rep

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Herbal medicine, a multi-component treatment, has been extensively practiced for treating various symptoms and diseases. However, its molecular mechanism of action on the human body is unknown, which impedes the development and application of herbal medicine. To address this, recent studies are increasingly adopting systems pharmacology, which interprets pharmacological effects of drugs from consequences of the interaction networks that drugs might have. Most conventional network-based approaches collect associations of herb-compound, compound-target, and target-disease from individual databases, respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlying herbal treatment. More recently, rapid advances in highthroughput omics technology have led numerous studies to exploring gene expression profiles induced by herbal treatments to elicit information on direct associations between herbs and genes at the genome-wide scale. In this review, we summarize key databases and computational methods utilized in systems pharmacology for studying herbal medicine. We also highlight recent studies that identify modes of action or novel indications of herbal medicine by harnessing drug-induced transcriptome data. [

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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway

Cited by 21 publications

References 40 publications

The Roles of Immune Cells in the Pathogenesis of Fibrosis

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Natural Product-Based Potential Therapeutic Interventions of Pulmonary Fibrosis

Systems pharmacology approaches in herbal medicine research: a brief review

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