Fehlerquellen in der automatisierten statischen Perimetrie

Pa, Rabineau

doi:10.1055/s-2008-1046375

Cited by 5 publications

(2 citation statements)

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“…improvement in visual performance after radiation of optic neuropathy that resulted from Graves’ disease [41]. We also tested a semi-automated pupillometry on the Octopus [42] and analysed the sources of error in automated static perimetry [43, 44] and the diagnostic role of the peripheral visual field [45]. Our main interest focussed, however, on the short- and long-term fluctuations of the visual fields [46–49].…”

Section: Visual Field Testing and Ocular Blood Flowmentioning

confidence: 99%

The discovery of the Flammer syndrome: a historical and personal perspective

Flammer

Konieczka

2017

EPMA Journal

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This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels. Their retinal vessels were more rigid and irregular and responded less to flickering light. Holistic investigation demonstrated low blood pressure, silent myocardial ischaemia, altered beat-to-beat variation, altered gene expression in the lymphocytes, slightly increased plasma endothelin level and increased systemic oxidative stress. This combination of signs and symptoms was better described by the term primary vascular dysregulation (PVD) than by VS. Subsequent studies showed additional symptoms frequently related to PVD, such as low body mass index, cold extremities combined with slightly increased core temperature, prolonged sleep onset time, reduced feelings of thirst, increased sensitivity to smell and also for certain drugs and increased retinal venous pressure. To better characterise this entire syndrome, the term Flammer syndrome (FS) was introduced. Most subjects with FS were healthy. Nevertheless, FS seemed to increase the risk for certain eye diseases, particularly in younger patients. This included normal-tension glaucoma, anterior ischaemic optic neuropathy, retinal vein occlusions, Susac syndrome and central serous chorioretinopathy. Hereditary diseases, such as Leber’s optic neuropathy or retinitis pigmentosa, were also associated with FS, and FS symptoms and sings occurred more frequent in patients with multiple sclerosis or with acute hearing loss. Further research should lead to a more concise definition of FS, a precise diagnosis and tools for recognizing people at risk for associated diseases. This may ultimately lead to more efficient and more personalised treatment.

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Section: Visual Field Testing and Ocular Blood Flowmentioning

confidence: 99%

The discovery of the Flammer syndrome: a historical and personal perspective

Flammer

Konieczka

2017

EPMA Journal

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“…In der vorliegenden Studie wird die Gruppenzuordnung anhand des Vorhandenseins oder Fehiens von Gesichtsfelddefekten bei der computergesteuerten statischen 30°-Perimetrie vorgenommen. Auch wenn isolierte relative Skotome in einem Prufpunkt noch als normal angesehen werden konnen (25), werden in der vorliegenden Studie diese Patienten von der Zuordnung zu der Kontroligruppe ausgeschlossen. Der morphologische Aspekt der Exkavation wird unberucksichtigt gelassen.…”

Section: Vergleich Der Glaukom-und Kontroilpapillenunclassified

Volumetrische Papillenanalyse mit Hilfe der Laser-Scanning-Tomographie - Parameterdefinition und Vergleich von Glaukom- und Kontrollpapillen

Burk

Rohrschneider

Noack

et al. 1991

Klin Monatsbl Augenheilkd

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We performed a three-dimensional structure analysis of the optic disc in 65 eyes of 65 patients (38 glaucoma patients, 27 control-group patients) using laser scanning tomography. Patients classified as glaucoma showed at least 3 points with a relative scotoma of -10 db loss or greater compared to age matched controls on static 30 degrees computerized perimetry. Control-group patients showed no relative scotoma outside the blind spot area compared to age matched controls. One way analysis of variance revealed statistically significant differences between the glaucoma (G) and the control-group (C) for excavation volume (+0.57 +/- 0.37 mm3 G/0.31 +/- 0.27 mm3 C, p less than 0.01), for the 3rd moment of the frequency distribution of excavation depths readings (-0.01 +/- -0.12 G/-0.13 +/- -0.09 C, p less than 0.001), area ratio (0.75 +/- 0.15 G/0.57 +/- 0.16 C, p less than 0.001), depth area ratio (0.35 +/- 0.24 G/0.18 +/- 0.12 C, p less than 0.001). A stepwise discriminant analysis classified 32 of 38 (84.2%) glaucoma discs and 21 of 27 (77.8%) control-group discs by a linear combination of 5 out of 15 topographic parameters. The results suggest that a combination of topographic parameters may provide an objective optic disc classification.

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Value of the Computed Visual Field in Clinical Glaucoma

Sampaolesi

Zárate

2013

The Glaucomas

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Fehlerquellen in der automatisierten statischen Perimetrie

Cited by 5 publications

References 1 publication

The discovery of the Flammer syndrome: a historical and personal perspective

The discovery of the Flammer syndrome: a historical and personal perspective

Volumetrische Papillenanalyse mit Hilfe der Laser-Scanning-Tomographie - Parameterdefinition und Vergleich von Glaukom- und Kontrollpapillen

Value of the Computed Visual Field in Clinical Glaucoma

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