Two receiving and two finishing trials evaluated energy source and escape protein supplementation for calves. In receiving Trial 1, 398 calves (257 ± 24 kg BW) were used in a 2 × 2 factorial arrangement of treatments. Energy sources were dryrolled corn (DRC) and wet corn gluten feed (WCGF); each was fed without or with supplemental escape protein (EP). Calves fed WCGF gained slower ( P < .05) and consumed less DM ( P < .01) than calves fed DRC. Feed efficiency improved ( P < .10) with EP supplementation. In finishing Trial 1, 240 calves (305 ± 21 kg BW) were used. The arrangement of treatments was the same as in receiving Trial 1. Calves fed DRC/WCGF tended ( P = .15) to be more efficient and consumed less DM ( P < .05) than calves fed DRC. In receiving Trial 2, 315 calves (252 ± 23 kg BW) were fed diets similar to those fed in receiving Trial 1. Calves fed WCGF consumed less DM ( P < .01), gained similarly ( P > .15), and were more efficient ( P < .10) than calves fed DRC. In finishing Trial 2, 320 calves (298 ± 23 kg BW) were fed diets containing DRC, DRC/WCGF, high-moisture corn (HMC), HMC/WCGF, and DRC/HMC; each was fed without or with supplemental EP. An energy source × protein supplement interaction was detected for gain ( P < .05) and efficiency ( P < .01). Results suggest that WCGF has a NE g greater than DRC in receiving diets and a NE g similar to that of DRC but lower than that of HMC in finishing diets.