Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa

Giorgio, Maria Rita De; Yoshioka, Mayumi; St‐Amand, Jonny

doi:10.1155/2010/371950

Cited by 2 publications

(3 citation statements)

References 37 publications

(49 reference statements)

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“…The hypothalamus is a key brain center upon which all these peripheral signals converge to regulate feeding behaviour and EI [ 43 ]. Therefore, as a preliminary step to discover the peripheral factor controlling fat intake and other determinants of energy balance, we previously used functional genomic strategy to investigate gastric, intestinal, fat, and hypothalamic genes differentially regulated by the ingestion of HF and LF meals [ 44 , 45 , 46 , 47 ].…”

Section: Focusing On Lipids In Obesity and Metabolic Disordersmentioning

confidence: 99%

“…Functional genomics have been proved as a strong tool to characterize many genes specifically induced by different conditions including those related to obesity and within the context of diet and exercise [ 48 , 49 , 50 ]. For instance, we have identified hundreds of genes modulated after HF or LF meals using the serial analysis of gene expression (SAGE) method [ 44 , 45 , 46 , 47 ].…”

Section: Trefoil Factor 2 ( Tff2 ) As a High-fat-induced Genementioning

confidence: 99%

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Trefoil Factor Family Member 2: From a High-Fat-Induced Gene to a Potential Obesity Therapy Target

Ghanemi

Yoshioka²,

St‐Amand

2021

Metabolites

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Obesity has its epidemiological patterns continuously increasing. With controlling both diet and exercise being the main approaches to manage the energy metabolism balance, a high-fat (HF) diet is of particular importance. Indeed, lipids have a low satiety potential but a high caloric density. Thus, focusing on pharmacologically targetable pathways remains an approach with promising therapeutic potential. Within this context, trefoil factor family member 2 (Tff2) has been characterized as specifically induced by HF diet rather than low-fat diet. TFF2 has also been linked to diverse neurological mechanisms and metabolic patterns suggesting its role in energy balance. The hypothesis is that TFF2 would be a HF diet-induced signal that regulates metabolism with a focus on lipids. Within this review, we put the spotlight on key findings highlighting this line of thought. Importantly, the hypothetical mechanisms pointed highlight TFF2 as an important contributor to obesity development via increasing lipids intestinal absorption and anabolism. Therefore, an outlook for future experimental activities and evaluation of the therapeutic potential of TFF2 inhibition is given. Indeed, its knockdown or downregulation would contribute to an antiobesity phenotype. We believe this work represents an addition to our understanding of the lipidic molecular implications in obesity, which will contribute to develop therapies aiming to manage the lipidic metabolic pathways including the absorption, storage and metabolism via targeting TFF2-related pathways. We briefly discuss important relevant concepts for both basic and clinical researchers.

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Section: Focusing On Lipids In Obesity and Metabolic Disordersmentioning

confidence: 99%

Section: Trefoil Factor 2 ( Tff2 ) As a High-fat-induced Genementioning

confidence: 99%

Trefoil Factor Family Member 2: From a High-Fat-Induced Gene to a Potential Obesity Therapy Target

Ghanemi

Yoshioka²,

St‐Amand

2021

Metabolites

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“…As an example of a potential signal molecule, the trefoil factor 2 ( Tff2 ) has been identified as a newly found HF-specific gene [ 106 ] for which its deficiency in mice leads to a protection from HF diet-induced obesity [ 111 , 112 ]. Among the hundreds of genes that are modulated after HF or LF meal ingestion [ 106 , 113 , 114 , 115 , 116 ], we put a spotlight on the Tff2 and its pathway as a potential targetable pathway for obesity molecular therapies. Indeed, this gene is upregulated by HF (and not LF) diet [ 106 ] which suggests it is a specific acute HF-induced signals that may impact food intake regulation.…”

Section: Diet-related Genes: a Focus On High-fat Diet To Identify mentioning

confidence: 99%

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars

Ghanemi

Melouane

Yoshioka

et al. 2020

Genes

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The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are yet to be fully revealed. This limits both our understanding of pathogenesis and therapeutic progress toward treating the obesity epidemic. The current anti-obesity approaches are mainly a controlled diet and exercise which could have limitations. For instance, the “classical” anti-obesity approach of exercise might not be practical for patients suffering from disabilities that prevent them from routine exercise. Therefore, therapeutic alternatives are urgently required. Within this context, pharmacological agents could be relatively efficient in association to an adequate diet that remains the most efficient approach in such situation. Herein, we put a spotlight on potential therapeutic targets for obesity identified following differential genes expression-based studies aiming to find genes that are differentially expressed under diverse conditions depending on physical activity and diet (mainly high-fat), two key factors influencing obesity development and prognosis. Such functional genomics approaches contribute to elucidate the molecular mechanisms that both control obesity development and switch the genetic, biochemical, and metabolic pathways toward a specific energy balance phenotype. It is important to clarify that by “gene-related pathways”, we refer to genes, the corresponding proteins and their potential receptors, the enzymes and molecules within both the cells in the intercellular space, that are related to the activation, the regulation, or the inactivation of the gene or its corresponding protein or pathways. We believe that this emerging area of functional genomics-related exploration will not only lead to novel mechanisms but also new applications and implications along with a new generation of treatments for obesity and the related metabolic disorders especially with the modern advances in pharmacological drug targeting and functional genomics techniques.

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Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa

Cited by 2 publications

References 37 publications

Trefoil Factor Family Member 2: From a High-Fat-Induced Gene to a Potential Obesity Therapy Target

Trefoil Factor Family Member 2: From a High-Fat-Induced Gene to a Potential Obesity Therapy Target

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars

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