Feeding Orange Pulp Improved Bone Quality in a Rat Model of Male Osteoporosis

Flavonoid Intake and Bone Health

“…Orange juice and pulp prevented bone loss in castrated male rats and increased cortical thickness in a dose-dependent manner (40). The active compound is thought to be hesperidin, the most abundant flavonone in citrus fruits, since similar bone protective effects in OVX rats were reported with this purified compound (41).…”

Chemistry and Pharmacology of Citrus sinensis

“…Administration of ethanol extract of leaves and peel of C. sinensis (5 mg/kg) on ovariectomized rats, increased trabecular bone mineral content and bone mineral density of tibia as well as improved the levels of phosphorus and calcium reducing the bone loss [93]. The effects of feeding orange pulp on bone quality in a male rat with osteoporosis model improved some characteristics of bone structure [94]. Thus, alternative approaches and investigations for managing osteoporosis are needed and in this regard some evaluations of the anti-osteoporotic activity of C. sinensis , showed that it could be beneficial, safe and effective in management of osteoporosis.…”

Molecular Mechanisms Underlying the Actions of Dietary Factors on the Skeleton

“…In addition, dietary antioxidants such as N-acetylcysteine and vitamin E derivatives and anti-inflammatory agents such as the soluble TNF antagonist sTNFR1 have been shown to be effective in preventing bone loss under these conditions (Almeida et al, 2010a;Chen et al, 2008bChen et al, , 2011Lee et al, 2009;Wahl et al, 2007Wahl et al, , 2010. Soy products and fruits such as BB and fruit juices such as orange juice have been shown to have ERindependent antioxidant and anti-inflammatory effects in vivo in several tissues (Morrow et al, 2009;Nagarajan, 2010;Wu et al, 2010). It is therefore likely that these dietary factors exert their skeletal actions at least in part via antioxidant/anti-inflammatory effects on bone cells.…”