Feeding of banana flower and pseudostem to diabetic rats results in modulation of renal GLUTs, TGFβ, PKC and extracellular matrix components

Jamuna, J. Bhaskar; Nandini, C.

doi:10.1016/j.numecd.2013.12.003

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Most of the studies for GLUT1 evaluation in these models were carried out in streptozotocin (STZ) rats. They predominantly reported higher GLUT1 protein [79][80][81][82] and corresponding mRNA [81][82][83][84][85] contents in the whole kidney and increased GLUT1 protein [86,87] and mRNA [86,88,89] in the cortex. Nonetheless, these studies are yet controversial [22,67,[90][91][92][93].…”

Section: Tubular Glucose Transporters In Animal Models Ofmentioning

confidence: 99%

“…Reports of SGLT1 protein [80,84,103] and mRNA [83-85, 92, 93, 98] contents in PTs of T1D murine models are also contradictory while in T2D models only mRNA expression seems to be upregulated [22,90,92,98,100,[103][104][105][106]. SGLT2 has been studied in many models of diabetes, and the results suggest increased protein [32,67,84,85,90,94,99,[107][108][109][110][111] and mRNA [22,32,83,85,100,104,[106][107][108][109]112] contents and activity [108] despite some controversial results [85,93,98,100,105,113].…”

Section: Tubular Glucose Transporters In Animal Models Ofmentioning

confidence: 99%

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Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Moreira

Muscelli

2020

Journal of Diabetes Research

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Renal proximal tubules reabsorb glucose from the glomerular filtrate and release it back into the circulation. Modulation of glomerular filtration and renal glucose disposal are some of the insulin actions, but little is known about a possible insulin effect on tubular glucose reabsorption. This review is aimed at synthesizing the current knowledge about insulin action on glucose handling by proximal tubules. Method. A systematic article selection from Medline (PubMed) and Embase between 2008 and 2019. 180 selected articles were clustered into topics (renal insulin handling, proximal tubule glucose transport, renal gluconeogenesis, and renal insulin resistance). Summary of Results. Insulin upregulates its renal uptake and degradation, and there is probably a renal site-specific insulin action and resistance; studies in diabetic animal models suggest that insulin increases renal SGLT2 protein content; in vivo human studies on glucose transport are few, and results of glucose transporter protein and mRNA contents are conflicting in human kidney biopsies; maximum renal glucose reabsorptive capacity is higher in diabetic patients than in healthy subjects; glucose stimulates SGLT1, SGLT2, and GLUT2 in renal cell cultures while insulin raises SGLT2 protein availability and activity and seems to directly inhibit the SGLT1 activity despite it activating this transporter indirectly. Besides, insulin regulates SGLT2 inhibitor bioavailability, inhibits renal gluconeogenesis, and interferes with Na+K+ATPase activity impacting on glucose transport. Conclusion. Available data points to an important insulin participation in renal glucose handling, including tubular glucose transport, but human studies with reproducible and comparable method are still needed.

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Section: Tubular Glucose Transporters In Animal Models Ofmentioning

confidence: 99%

Section: Tubular Glucose Transporters In Animal Models Ofmentioning

confidence: 99%

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Moreira

Muscelli

2020

Journal of Diabetes Research

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“…Previous reports from DN patient and animal model have indicated that inflammation plays a significant role in the development and progression of DN . Activation of PKC is considered as an important signalling molecule in progression of DN as it attributed to an abnormality in vascular and cellular processes causing vascular permeability, endothelial dysfunction, angiogenesis, ECM accumulation, basement thickening and alteration in various enzymatic activity and transcription factors . PKC isoforms such as PKC‐α, β, δ and ε are involved and activated in hyperglycaemia‐mediated nephropathy .…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] Activation of PKC is considered as an important signalling molecule in progression of DN as it attributed to an abnormality in vascular and cellular processes causing vascular permeability, endothelial dysfunction, angiogenesis, ECM accumulation, basement thickening and alteration in various enzymatic activity and transcription factors. [7][8][9] PKC isoforms such as PKC-a, b, d and e are involved and activated in hyperglycaemia-mediated nephropathy. [9,10] Several reports suggested that among these isoforms, activated PKC-a induces NF-kB activation in the kidney tissue.…”

Section: Introductionmentioning

confidence: 99%

Pueraria tuberosaextract inhibits iNOS and IL-6 through suppression of PKC-α and NF-kB pathway in diabetes-induced nephropathy

Shukla

Banerjee

Tripathi

2018

Journal of Pharmacy and Pharmacology

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“…It is widely grown in the tropics and subtropics, where it acts as an important dietary component, both raw (as a dessert fruit) and cooked (often as the major source of carbohydrates) [ 2 ]. Banana produces a large number of flower buds, which have been developed for edible and pharmaceutical functions due to their abundance of nutrients and medicinal contents [ 3 , 4 ]. In recent years, banana flower thrips ( Thrips hawaiiensis Morgan) that damage flower buds have become major pests of banana crops [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of flower thrips (Thysanoptera: Thripidae) on nutritional quality of banana (Zingiberales: Musaceae) buds

Huang

Chen

et al. 2018

PLoS ONE

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The abundance of banana flower thrips (Thrips hawaiiensis Morgan) in a banana (Musa acuminata Colla “Williams” cultivar) plantation was investigated using yellow sticky traps (29.70 cm × 21.00 cm) in 2015. Banana flower thrips occurred throughout the year with monthly variation, and the maximum occurrence was observed in October and November during the bud burst (73.80 ± 6.32 adults/trap) and young fruit (70.06 ± 5.69 adults/trap) periods. The damage rates were as follows: interior flowers >3rd-layer flowers > 2nd-layer flowers > 1st-layer flowers > young fruits. This result indicates that thrips migrated to lower bracts, young fruits, and other flower buds as bracts gradually opened. Results also showed that the reducing sugar, vitamin C, protein and ash contents in thrips-damaged flowers were all significantly lower than those in undamaged flowers, while there was no significant difference between damaged and undamaged young banana fruit. Our results indicated that the abundances of banana flower thrips were closely associated with the growing stage of banana. Thrips mainly infested flower buds and caused a reduction in nutrients for the host plant, especially the reducing sugar and vitamin C contents, which reduced the nutritional quality of banana fruits and the quality of flower bud by-products of banana.

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Feeding of banana flower and pseudostem to diabetic rats results in modulation of renal GLUTs, TGFβ, PKC and extracellular matrix components

Cited by 11 publications

References 23 publications

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Pueraria tuberosaextract inhibits iNOS and IL-6 through suppression of PKC-α and NF-kB pathway in diabetes-induced nephropathy

Effects of flower thrips (Thysanoptera: Thripidae) on nutritional quality of banana (Zingiberales: Musaceae) buds

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