Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth

Kocik, Janusz; Bałan, Barbara J.; Zdanowski, Robert; Jung, Leszek; Skopińska-Różewska, Ewa; Skopiński, Piotr

doi:10.5114/ceji.2014.42116

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…All doses of Biostymin (2, 4, 8 µl) significantly diminished the number of newly-formed blood vessels in comparison to the control. Similar angio-inhibitory effect in TIA test was obtained by our group for another Aloe preparation, Aloe vera drinking gel (50 or 150 µl) [ 115 ].…”

Section: Introductionsupporting

confidence: 81%

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Radomska-Leśniewska¹,

Skopiński²,

Bałan³

et al. 2015

cejoi

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Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.

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Section: Introductionsupporting

confidence: 81%

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Radomska-Leśniewska¹,

Skopiński²,

Bałan³

et al. 2015

cejoi

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“…The number of newly-formed blood vessels was markedly reduced in the tumour tissue of L-1 sarcoma-bearing BALB/c mice after administration of the A. vera gel (156). By contrast, topical application of 1 and 2% A. vera cream activated angiogenesis, with its levels peaking on day 5, in a full-thickness wound model in Sprague Dawley rats (157).…”

Section: Angiogenesismentioning

confidence: 99%

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

2021

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Naturally occurring components from various species of Aloe have been used as traditional folk medicine since the ancient times. Over the last few decades, the therapeutic effects of extracts and phytochemical compounds obtained from Aloe vera have been proven in preclinical and clinical studies. Recently, compounds from other Aloe species apart from Aloe vera have been investigated for the treatment of different diseases, with a particular focus on cancer. In the present review, the effects of phytochemical compounds obtained from different Aloe species are discussed, with a specific focus on the effects on cell signalling in cancer and normal cells, and their selectivity and efficacy. This information will be useful for the application of Aloe-derived compounds as therapeutic agents, either alone or in combination with other standard drugs for cancer treatment. Contents 1. Introduction 2. Cell death initiation by the phytochemical compounds of Aloe 3. Anticancer selectivity 4. Cell cycle regulation 5. Cell signalling 6. Angiogenesis 7. Migration and invasion 8. Inflammation and immunomodulation (TNF-α/NF-κB pathway) 9. Recommendations for future applications 10. Conclusions

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“…Perbedaan yang ditemukan baik secara keseluruhan maupun antar kelompok (berdasarkan dosis dan jenis sumber prebiotik) menunjukkan bahwa setiap sumber prebiotik mengandung komponen prebiotik tertentu yang spesifik dan memiliki mekanisme yang berbeda sehingga pengaruhnya terhadap penurunan jumlah koloni bakteri juga berbeda. Lidah buaya mengandung polisakarida tinggi yaitu acemannan dan fruktan yang dapat berperan sebagai prebiotik, antibakteri, antiinflamasi dan membantu penyembuhan luka (Kocik et al, 2014;Pothuraju et al, 2016;Sierra-García et al, 2014); sedangkan coklat/kakao (Theobroma cacao) mengandung inulin, FOS dan GOS (Gonzalez et al, 2011;Morais et al, 2014) yang sudah diketahui memiliki efek menguntungkan bagi populasi mikroba usus (Di Bartolomeo et al, 2013). Semuanya ini secara umum berkhasiat sebagai prebiotik, karena dosisnya yang berbeda, maka efeknya dalam membantu penyembuhan luka juga berbeda; semakin tinggi dosisnya, semakin baik efeknya.…”

Section: Pembahasanunclassified

Combination of Aloe Vera and Chocolate to Reduce The Number of The Colony of Staphylococcus Aureus

Suwandi¹,

Nuswantoro²,

Sugito³

2022

JTKB

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Aloe vera (AV) and chocolate are good examples of functional foods because they contain prebiotics that can help the host defend itself against harmful bacterial infections such as Staphylococcus aureus. Many studies have used AV or chocolate alone to help fight infection, but not much is known about using both together. This study aims to count the number of colonies of S. aureus infected on mice’s skin (Mus musculus) after being given AV and cocoa in certain doses per kilogram of body weight. A total of 35 healthy male mice were infected with S. aureus in the superficial area of the nape of the skin. After that, they were divided into seven groups, each consisting of 5 mice, and given the following treatments: given 50 mg/kg BW AV (group A), 50 mg/kg BW brown (B), 50 mg/kg BW combination of AV and chocolate (C), given 75 mg/kg BW AV (D), given 75 mg/kg BW brown (E), given 75 mg/kg BW combination of AV and chocolate (F), and control (without prebiotic administration), K). Mice that were given 75 mg/kg BW AV/chocolate/AV+chocolate had a better ability to reduce the number of bacteria than those that were given 50 mg/kg BW AV/chocolate/AV+chocolate. In addition, rats that were given AV and chocolate together had a better ability to reduce the number of bacteria than those that were given either only AV or chocolate alone. Prebiotics are both found in AV and chocolate but with different substances. This causes mice given a combination of prebiotics to be considered better than those given only one type of prebiotic source.

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Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth

Cited by 8 publications

References 23 publications

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

Combination of Aloe Vera and Chocolate to Reduce The Number of The Colony of Staphylococcus Aureus

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