Feeding-induced increases in insulin do not suppress secretion of growth hormone☆

McMahon, C.D.; Chapin, L.T.; Lookingland, Keith J.; Radcliff, R.P.; Tucker, H.A.

doi:10.1016/s0739-7240(99)00050-8

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…It is possible that feeding immediately after each treatment with GHRP-2 decreased the secretion of GH and reduced GHRP-2-induced GH responses. Secretion of GH, as well as GHreleasing factor-induced GH response, has been shown to decrease during and for several hours after feeding (Moseley et al, 1988;Trenkle et al, 1989), although the precise mechanism underlying the decrease in the response is still unclear (McMahon et al, 1999). Another possible explanation is that the absorption of the peptide was limited and delayed by the presence of feed in the gastrointestinal tract.…”

Section: Oral Administration On Gh Release In Swinementioning

confidence: 99%

Characterization of Growth Hormone Secretion to Growth Hormone-releasing Peptide-2 in Domestic Animals - A Review

Roh¹,

Lee²,

Phung³

et al. 2002

Asian Australas. J. Anim. Sci

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Growth hormone-releasing peptide-2 (GHRP-2, also named KP102) is a new hexapeptide of a series of synthetic growth hormone-releasing peptides (GHRPs) which stimulates the secretion of growth hormone (GH) in vitro and in vivo in several species including calf, sheep and pig. The GH-releasing activity of GHRP-2 is two to three times more effective than that of the original GHRP-6, and GHRP-1 in the rats and humans. To date, GHRP-2 seems to be the most potent member of the family of GHRPs. Since the GHRPs are short peptides (5-7 amino acid residues), they are synthesized easily and are not as readily degraded in plasma as GHreleasing hormone (GHRH). These features ameliorate their potential on domestic animals because of their chemical nature the GHRPs are efficacious when administered i.v. orally or orally. However, studies in cow, pig and sheep do not indicate such a close relationship between GHRH, somatostatin (SS) and GH, calling into question the general applicability of the human and rat models. Perhaps there is an important role for an endogenous GHRP in the regulation of GH secretion in domestic animals. This review provides an overview on the current knowledge of physiological role of GHRP-2 in domestic animals.

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Section: Oral Administration On Gh Release In Swinementioning

confidence: 99%