Feeding blueberry diets inhibits angiotensin II-converting enzyme (ACE) activity in spontaneously hypertensive stroke-prone rats

Wiseman, Waylon WisemanW.; Egan, Jennifer M; Slemmer, Jennifer E.; Shaughnessy, Kevin S.; Ballem, Katherine BallemK.; Gottschall‐Pass, Katherine; Sweeney, Marva I.

doi:10.1139/y10-101

Cited by 30 publications

(19 citation statements)

References 16 publications

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“…Similarly, grapes and grape seed extract have also been shown not to influence BP in healthy or diseased individuals (302,472,488,509). Animal studies have been more positive, showing BP-lowering effects of berry extracts after long-term consumption, but only in models of hypertension (130,415,497). There is no evident reason on why some studies show a positive effect on BP and others not, although different types of berries may contain very different profiles of (poly)phenols (41).…”

Section: Berriesmentioning

confidence: 99%

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Rio

Rodriguez-Mateos

Spencer

et al. 2013

Antioxidants & Redox Signaling

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1,422

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Human intervention trials have provided evidence for protective effects of various (poly)phenol-rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer. While there are considerable data suggesting benefits of (poly)phenol intake, conclusions regarding their preventive potential remain unresolved due to several limitations in existing studies. Bioactivity investigations using cell lines have made an extensive use of both (poly)phenolic aglycones and sugar conjugates, these being the typical forms that exist in planta, at concentrations in the low-lM-to-mM range. However, after ingestion, dietary (poly)phenolics appear in the circulatory system not as the parent compounds, but as phase II metabolites, and their presence in plasma after dietary intake rarely exceeds nM concentrations. Substantial quantities of both the parent compounds and their metabolites pass to the colon where they are degraded by the action of the local microbiota, giving rise principally to small phenolic acid and aromatic catabolites that are absorbed into the circulatory system. This comprehensive review describes the different groups of compounds that have been reported to be involved in human nutrition, their fate in the body as they pass through the gastrointestinal tract and are absorbed into the circulatory system, the evidence of their impact on human chronic diseases, and the possible mechanisms of action through which (poly)phenol metabolites and catabolites may exert these protective actions. It is concluded that better performed in vivo intervention and in vitro mechanistic studies are needed to fully understand how these molecules interact with human physiological and pathological processes. Antioxid. Redox Signal. 18, 1818-1892.

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Section: Berriesmentioning

confidence: 99%

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Rio

Rodriguez-Mateos

Spencer

et al. 2013

Antioxidants & Redox Signaling

2,086

1,422

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“…In the stroke prone SHRs, consumption of freeze dried blueberries (3% w/w) for 8 weeks reduced blood pressure by 19% by week 4 and 30% by week 6 relative to controls [217]. This reduction in blood pressure may in part be due to the inhibition of ACE activity and lowered Ang II levels in the plasma [218]. Reduction of blood pressure in SHR was also accomplished by intake of raspberry ethyl extracts; this was accompanied by increase in SOD and serum NO and lowered MDA and plasma ET-1 [219].…”

Section: Functional Foods Rich In Polyphenolsmentioning

confidence: 99%

Polyphenols: Benefits to the Cardiovascular System in Health and in Aging

et al. 2013

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Numerous studies have demonstrated the importance of naturally occurring dietary polyphenols in promoting cardiovascular health and emphasized the significant role these compounds play in limiting the effects of cellular aging. Polyphenols such as resveratrol, epigallocatechin gallate (EGCG), and curcumin have been acknowledged for having beneficial effects on cardiovascular health, while some have also been shown to be protective in aging. This review highlights the literature surrounding this topic on the prominently studied and documented polyphenols as pertaining to cardiovascular health and aging.

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“…Two recent clinical studies where participants consumed blueberries formulated into a beverage have demonstrated improved insulin sensitivity in insulin-resistant subjects [12] and decreased blood pressure and markers of lipid oxidation in metabolic syndrome patients [13] compared to the control intervention. Compared to a control diet, supplementation with blueberries improved vascular tone and decreased blood pressure in spontaneously hypertensive rats [14-15], at least partially due to inhibition of ACE activity in blood [16]. A single dose of an anthocyanin-enriched blueberry fraction administered to diet-induced obese and diabetic C57BL/6 mice significantly lowered blood glucose levels [17].…”

Section: Introductionmentioning

confidence: 99%

Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice

Roopchand

Kühn

Rojo

et al. 2013

Pharmacological Research

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Defatted soybean flour (DSF) can sorb and concentrate blueberry anthocyanins and other polyphenols, but not sugars. In this study blueberry polyphenol-enriched DSF (BB-DSF) or DSF were incorporated into very high fat diet (VHFD) formulations and provided ad libitum to obese and hyperglycemic C57BL/6 mice for 13 weeks to investigate anti-diabetic effects. Compared to the VHFD containing DSF, the diet supplemented with BB-DSF reduced weight gain by 5.6%, improved glucose tolerance, and lowered fasting blood glucose levels in mice within 7 weeks of intervention. Serum cholesterol of mice consuming the BB-DSF-supplemented diet was 13.2% lower than mice on the diet containing DSF. Compounds were eluted from DSF and BB-DSF for in vitro assays of glucose production and uptake. Compared to untreated control, doses of BB-DSF eluate containing 0.05 – 10 μg/μL of blueberry anthocyanins significantly reduced glucose production by 24% - 74% in H4IIE rat hepatocytes, but did not increase glucose uptake in L6 myotubes. The results indicate that delivery of blueberry polyphenols stabilized in a high-protein food matrix may be useful for the dietary management of pre-diabetes and/or diabetes.

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Feeding blueberry diets inhibits angiotensin II-converting enzyme (ACE) activity in spontaneously hypertensive stroke-prone rats

Cited by 30 publications

References 16 publications

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Polyphenols: Benefits to the Cardiovascular System in Health and in Aging

Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice

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