Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens

Hernández, Luis; Hoebel, Bartley G.

doi:10.1016/0031-9384(88)90324-1

Cited by 335 publications

(154 citation statements)

References 25 publications

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“…This reward link is activated by natural as well as chemical reinforcers, as reviewed previously (Larsson and Engel 2004). Involvement of this reward link in druginduced as well as natural reward has been implied, thus food as well as alcohol intake increases the ventral tegmental acetylcholine levels as well as accumbal dopamine levels (Hernandez and Hoebel 1988;Larsson et al 2005;Rada et al 2000). GHS-R1A is expressed in the LDTg (Guan et al 1997), specifically on cholinergic cells , suggesting that ghrelin may have direct effects in this reward node.…”

Section: The Central Ghrelin Signalling System Integrates With a Key mentioning

confidence: 85%

The role of the central ghrelin system in reward from food and chemical drugs

Dickson

Egecioglu

Landgren

et al. 2011

Molecular and Cellular Endocrinology

217

168

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Here we review recent advances that identify a role for the central ghrelin signalling system in reward from both natural rewards (such as food) and artificial rewards (that include alcohol and drugs of abuse). Whereas ghrelin emerged as a stomach-derived hormone involved in energy balance, hunger and meal initiation via hypothalamic circuits, it now seems clear that it also has a role in motivated reward-driven behaviours via activation of the so-called "cholinergic-dopaminergic reward link". This reward link comprises a dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens together with a cholinergic input, arising primarily from the laterodorsal tegmental area. Ghrelin administration into the VTA or LDTg activates the "cholinergicdopaminergic" reward link, suggesting that ghrelin may increase the incentive value of motivated behaviours such as reward-seeking behaviour ("wanting" or "incentive motivation"). Further, direct injection of ghrelin into the brain ventricles or into the VTA

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Section: The Central Ghrelin Signalling System Integrates With a Key mentioning

confidence: 85%

The role of the central ghrelin system in reward from food and chemical drugs

Dickson

Egecioglu

Landgren

et al. 2011

Molecular and Cellular Endocrinology

217

168

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“…It has been reported that DA release at the mPFC and/or the nucleus accumbens was increased among rats responding for food reward (Hernandez and Hoebel, 1988) or in response to relatively novel foods (Ahn and Phillips, 1999;Bassareo and Di Chiara, 1997;Feenstra, 2000;Feenstra and Botterbom, 1996). As DA neuronal activity was also affected by perturbations of expected reward (delaying reward presentation or reducing reward duration), it was suggested that DA neuronal activity operates to influence the incentive value of the food reward Gratton, 1996, 1998).…”

Section: Discussionmentioning

confidence: 99%

Anticipatory Cues Differentially Provoke In Vivo Peptidergic and Monoaminergic Release at the Medial Prefrontal Cortex

Merali

McIntosh

Anisman

2004

Neuropsychopharmacol

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Like primary reinforcers, the anticipation of reward ought to affect neurochemical release in brain regions, such as the medial prefrontal cortex (mPFC), which are associated with appraisal processes. To assess the neurochemical changes associated with anticipation, rats were exposed to the pairing of auditory (60-dB white noise), visual, and olfactory cues with the daily presentation of a palatable snack (Cue Relevant group). Rats of a second group were similarly trained, but for a 2-week period, the snack was no longer provided following cue presentation (Extinction group). In the third condition, the presentation of the snack and cues was uncorrelated (Cue Irrelevant group). Analyses of dialysates collected in vivo from the mPFC revealed that release of corticotropin-releasing hormone (CRH), gastrinreleasing peptide (GRP), and the 5-HT catabolite, 5-hydroxyindole acetic acid (5-HIAA), had increased bilaterally in response to the anticipatory cues, whereas DA release increased only within the right mPFC. In the case of CRH and GRP, these increases were also apparent in the extinction condition, despite the fact that behavioral arousal to the anticipatory cues (increased exploration, rearing, grooming, and vigilance) was only evident in the Cue Relevant condition. In contrast, the elevated DA and 5-HIAA were apparent exclusively in the Cue Relevant condition. Thus, CRH and GRP systems may serve to allocate salience and/or incentive reward value to biologically significant stimuli or reflect the emotional response to the anticipatory stimulus. The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli.

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“…This disposition consists of instinctual behavioral tendencies that help organism to move accross sensorial configurations and to approach specific sources of stimulations, including salient non-reward events (Horvitz, 2000). The SEEKING 10 Nevertheless, every consummatory behavior also has an appetitive component (animals fluctuate between approaching/manipulating and consuming the food), and hence it is not surprising that DA transmission is enhanced during feeding, and partially controls food intake (Hernandez & Hoebel, 1988;Hoebel et al, 1989;Martel & Fantino, 1996;Ragnauth et al, 2000;Kelley & Berridge, 2002;MacDonald et al, 2004).…”

Section: The Affective Neuroethological Perspectivementioning

confidence: 99%

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

511

294

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The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning. The affective neuroethological perspective presented here, views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.A description of the anatomical framework in which the ML system is embedded is followed by the argument that the SEEKING disposition emerges through functional integration of ventral basal ganglia (BG) into thalamocortical activities. Filtering cortical and limbic input that spread into BG, DA transmission promotes the "release" of neural activity patterns that induce active SEEKING behaviors when expressed at the motor level. Reverberation of these patterns constitutes a neurodynamic process for the inclusion of cognitive and perceptual representations within the extended networks of the SEEKING urge. In this way, the SEEKING disposition influences attention, incentive salience, associative learning, and anticipatory predictions.In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive drive to persistent craving depending on the intensity of the affect. The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug seeking behaviors.

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Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens

Cited by 335 publications

References 25 publications

The role of the central ghrelin system in reward from food and chemical drugs

The role of the central ghrelin system in reward from food and chemical drugs

Anticipatory Cues Differentially Provoke In Vivo Peptidergic and Monoaminergic Release at the Medial Prefrontal Cortex

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

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