2013
DOI: 10.1016/j.domaniend.2013.01.005
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Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats

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Cited by 61 publications
(102 citation statements)
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“…The decrease in circulating Ca concentrations observed in the present study is in contrast to previous work in rodents where dietary 5-HTP supplementation increased circulating Ca and PTHrP concentrations (Laporta et al 2013a). One plausible explanation for this is that in the present experiment, blood samples were collected during the 2 h post-infusion period, whereas in the previous rodent experiments, blood samples for measuring Ca and PTHrP in response to 5-HTP administration were collected after several days and up to 2 weeks after treatment (Laporta et al 2013a(Laporta et al , 2014b. This suggests that physiological responses to increased serotonin concentrations are different depending on the time point that is evaluated post-treatment.…”
Section: Discussioncontrasting
confidence: 99%
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“…The decrease in circulating Ca concentrations observed in the present study is in contrast to previous work in rodents where dietary 5-HTP supplementation increased circulating Ca and PTHrP concentrations (Laporta et al 2013a). One plausible explanation for this is that in the present experiment, blood samples were collected during the 2 h post-infusion period, whereas in the previous rodent experiments, blood samples for measuring Ca and PTHrP in response to 5-HTP administration were collected after several days and up to 2 weeks after treatment (Laporta et al 2013a(Laporta et al , 2014b. This suggests that physiological responses to increased serotonin concentrations are different depending on the time point that is evaluated post-treatment.…”
Section: Discussioncontrasting
confidence: 99%
“…This implies that 5-HTP treatment shifts Ca from maternal circulation to other tissues, for example, the mammary gland, seeing as it is not being excreted in the urine. Our previous work in mice demonstrated that serotonin is responsible for increasing Ca pumps in the mammary gland and secretion into milk (Laporta et al 2013a(Laporta et al , 2014a. The decrease in circulating Ca concentrations observed in the present study is in contrast to previous work in rodents where dietary 5-HTP supplementation increased circulating Ca and PTHrP concentrations (Laporta et al 2013a).…”
Section: Discussionmentioning
confidence: 99%
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