In this paper, we show that a target control problem for semi-linear distributed parameter systems can be investigated in the framework of feedback spreading control (FSC) under speed constraints. The control laws which are proposed for a solution are designed in such a manner that they generate a spread which reaches the terminal conditions, provided that a lower bound condition on its speed holds. As a numerical example, we consider a semi-linear parabolic equation. The last part of the paper is devoted to study a partial differential equation (PDE) model from immunotherapy in the context of spreading control.