Feedback on SMS reminders to encourage adherence among patients taking antipsychotic medication: a cross-sectional survey nested within a randomised trial

Kannisto, Kati Anneli; Adams, Clive E; Koivunen, Marita; Katajisto, Jouko; Välimäki, Maritta

doi:10.1136/bmjopen-2015-008574

Cited by 35 publications

(44 citation statements)

References 75 publications

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“…We attempted to reach 558 participants by telephone for an interview; after the telephone calls were made, we had 403 completed questionnaires (response rate 72.2%, 403/558) [35]. The dropout rate from these telephone interviews was 27.8% (155/558).…”

Section: Resultsmentioning

confidence: 99%

Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems

Kannisto¹,

Korhonen²,

Adams³

et al. 2017

J Med Internet Res

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BackgroundClinical trials are the gold standard of evidence-based practice. Still many papers inadequately report methodology in randomized controlled trials (RCTs), particularly for mHealth interventions for people with serious mental health problems. To ensure robust enough evidence, it is important to understand which study phases are the most vulnerable in the field of mental health care.ObjectiveWe mapped the recruitment and the trial follow-up periods of participants to provide a picture of the dropout predictors from a mHealth-based trial. As an example, we used a mHealth-based multicenter RCT, titled “Mobile.Net,” targeted at people with serious mental health problems.MethodsRecruitment and follow-up processes of the Mobile.Net trial were monitored and analyzed. Recruitment outcomes were recorded as screened, eligible, consent not asked, refused, and enrolled. Patient engagement was recorded as follow-up outcomes: (1) attrition during short message service (SMS) text message intervention and (2) attrition during the 12-month follow-up period. Multiple regression analysis was used to identify which demographic factors were related to recruitment and retention.ResultsWe recruited 1139 patients during a 15-month period. Of 11,530 people screened, 36.31% (n=4186) were eligible. This eligible group tended to be significantly younger (mean 39.2, SD 13.2 years, P<.001) and more often women (2103/4181, 50.30%) than those who were not eligible (age: mean 43.7, SD 14.6 years; women: 3633/6514, 55.78%). At the point when potential participants were asked to give consent, a further 2278 refused. Those who refused were a little older (mean 40.2, SD 13.9 years) than those who agreed to participate (mean 38.3, SD 12.5 years; t1842=3.2, P<.001). We measured the outcomes after 12 months of the SMS text message intervention. Attrition from the SMS text message intervention was 4.8% (27/563). The patient dropout rate after 12 months was 0.36% (4/1123), as discovered from the register data. In all, 3.12% (35/1123) of the participants withdrew from the trial. However, dropout rates from the patient survey (either by paper or telephone interview) were 52.45% (589/1123) and 27.8% (155/558), respectively. Almost all participants (536/563, 95.2%) tolerated the intervention, but those who discontinued were more often women (21/27, 78%; P=.009). Finally, participants’ age (P<.001), gender (P<.001), vocational education (P=.04), and employment status (P<.001) seemed to predict their risk of dropping out from the postal survey.ConclusionsPatient recruitment and engagement in the 12-month follow-up conducted with a postal survey were the most vulnerable phases in the SMS text message-based trial. People with serious mental health problems may need extra support during the recruitment process and in engaging them in SMS text message-based trials to ensure robust enough evidence for mental health care.ClinicalTrialInternational Standard Randomized Controlled Trial Number (ISRCTN): 27704027; http://www.isrctn.com/ISRCTN27704027 (Archived...

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Section: Resultsmentioning

confidence: 99%

Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems

Kannisto¹,

Korhonen²,

Adams³

et al. 2017

J Med Internet Res

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“…Research has shown that patients with schizophrenia find text message reminders about medication adherence delivered to their phone useful and easy to use 16 . Therapies like cognitive behavioral therapy (CBT) are increasingly being shown effective in schizophrenia, showing high acceptability among patients and small-medium between group effects for psychotic symptoms, 17 and there is a growing research literature on the ability of smartphones to deliver CBT 18 .…”

Section: Introductionmentioning

confidence: 99%

Methodology and Reporting of Mobile Health and Smartphone Application Studies for Schizophrenia

Torous

Firth

Mueller

et al. 2017

Harv Rev Psychiatry

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The increasing prevalence of mobile devices among patients of all demographic groups has the potential to transform the ways we diagnose, monitor, treat, and study mental illness. As new tools and technologies emerge, clinicians and researchers are confronted with an increasing array of options for clinical assessment, through digital capture of the essential behavioral elements of a condition, and intervention, through formalized treatments, coaching, and other technology-assisted means of patient communication. And yet, as with any new set of tools for assessment or treatment of a medical condition, establishing and adhering to reporting guidelines – i.e., what works and under what conditions – is an essential component to the translational research process. Here, we review the methodological strengths and weaknesses in the existing literature on schizophrenia smartphone and wearables utilizing the recently published World Health Organization mHealth Evaluation, Reporting and Assessment (mERA) guidelines for evaluating mobile health applications. While growing evidence supports the feasibility of using several mobile tools in severe mental illness, most studies to date failed to adequately report accessibility, interoperability, costs, scalability, replicability, data security, usability testing, or compliance with national guidelines or regulatory statutes. Future research efforts addressing these specific gaps in the literature will help advance our understanding and realize the clinical potential of these new tools of psychiatry.

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“…For those service users without a smartphone or tablet, the paper booklet has been demonstrated to be just as effective in improving knowledge on legal rights. Smartphone applications offer other potential benefits for individuals affected by mental health disorders, such as reminders to encourage adherence (Kannisto et al 2015) and interventions to improve symptoms (Donker et al 2013) and thus should be seen as an effective and inexpensive method to offer support.…”

Section: Discussionmentioning

confidence: 99%

A randomized study of a smartphone application compared with booklet to improve service user’s knowledge of their legal rights

O’Donoghue

Roche²,

Naji

et al. 2017

Ir. j. psychol. Med.

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Background. The Mental Health Act 2001 has introduced significant changes to the process of admission to hospital for individuals affected by mental health disorders. This study aimed to determine whether a newly designed smartphone application could result in an improvement in service users' knowledge of their rights compared with the paper booklet.Methods. This was a randomized study conducted in an outpatient and day-hospital in North Dublin. Participants were randomized to receive the information booklet as either a smartphone application or in the paper form. A questionnaire which was scored from 0 to 10 was devised and was completed at baseline and at 1-week follow-up.Results. A total of 42 individuals completed the baseline and follow-up questionnaire and of these, 53.7% were female and the mean age was 38.2 years (S.D. ± 13.5). A total of 34.1% had a diagnosis of a psychotic disorder, 29.3% had a depressive disorder and 22% had bipolar-affective disorder. The mean score before the intervention in the total group was 3.5 (S.D. ± 2.2) and this increased to 5.8 (S.D. ± 2.2) at follow-up. Participants randomized to the smartphone application improving by a mean of 2.5 (S.D. ± 2.5), while those randomized to the booklet improving by a mean of 2.3 (S.D. ± 2.6), which was not statistically significant.Conclusions. Both forms of the information booklet showed improvement in service users' knowledge of their legal rights. It is possible that each individual will have preference for either a paper form or a smartphone form and this study suggests that both forms should be offered to each individual service user.

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Feedback on SMS reminders to encourage adherence among patients taking antipsychotic medication: a cross-sectional survey nested within a randomised trial

Cited by 35 publications

References 75 publications

Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems

Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems

Methodology and Reporting of Mobile Health and Smartphone Application Studies for Schizophrenia

A randomized study of a smartphone application compared with booklet to improve service user’s knowledge of their legal rights

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