Feedback control of temperature in specific geometry of porous media: application to hyperthermia

Rezvanian, Amir; Beigzadeh, Borhan; Markazi, Amir H.D.; Halabian, Mahdi

doi:10.1007/s10973-020-09597-9

Cited by 5 publications

(1 citation statement)

References 39 publications

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“…After 10 min of laser exposure at 2.6 W cm –2 , the temperature of 4-ATP-[BSANP PG ] ([Au] = 151.5 μg mL –1 ) increased from room temperature to 69.6 °C (Δ T = 44.5 °C, Figure A). Temperatures in the range of 41 to 47 °C can lead to cell death by hyperthermia . Comparatively, only a slight temperature change (Δ T = 4.7 °C) was observed for deionized water without the presence of 4-ATP-[BSANP PG ].…”

Section: Resultsmentioning

confidence: 96%

Protein-Templated Core/Shell Au Nanostructures for Intracellular Reactive Oxygen Species Detection by SERS

Anik

Pan

Jakaria

et al. 2022

ACS Appl. Nano Mater.

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Core/shell gold "raspberry" nanostructures capable of multiple therapeutic functionalities were synthesized using a template composed of monodispersed anionic protein (bovine serum albumin) nanoparticles coated with a cationic biopolymer (poly-L-lysine). The nanostructures exhibited high photothermal conversion efficiency when exposed to a near-infrared (NIR) laser, which led to significant cellular inhibition of A549 human lung cancer cells due to intracellular hyperthermia. The raspberry structures also provided hot spots for surface-enhanced Raman scattering (SERS) ratiometric sensing of intracellular reactive oxygen species (ROS) when modified with the Raman reporter molecule 4-aminothiophenol (4-ATP). ROS was detected in A549 lung cancer cells upon photothermal heating of internalized nanostructures, enabling a possible mechanism for feedback on therapeutic efficacy. This was confirmed by adding the antioxidant N-acetylcysteine (NAC) and using a complementary fluorescence technique, which showed that the amount of detectable intracellular ROS decreased. These safe-by-design gold raspberry nanostructures could be promising for simultaneous therapeutic applications and monitoring therapeutic efficacy.

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Section: Resultsmentioning

confidence: 96%