Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota1

Bosi, Paolo; Merialdi, G.; Scandurra, S.; Messori, Stefano; Bardasi, Lia; Nisi, I.; Russo, Domenico; Casini, L.; Trevisi, Paolo

doi:10.2527/jas.2010-3311

Cited by 49 publications

(48 citation statements)

References 25 publications

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“…Nucleotides and other feed additives, such as antimicrobial agents, may not demonstrate beneficial effects to weanling pigs fed with complex diets without exposure to stressful conditions. The efficacy of antimicrobials in improving the growth performance of weanling pigs has been well documented (CROMWELL, 2002;BOSI et al, 2011). However, these responses were greater in pigs raised under farm conditions compared to experimental conditions (NRC, 1998).…”

Section: Resultsmentioning

confidence: 99%

Performance and intestinal health of weanling pigs fed with dietary nucleotides

Andrade

Almeida

Sbardella

et al. 2016

SCA

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Previous studies reported benefits to growth performance, intestinal histology and reduced diarrhea for pigs supplemented with nucleotide additive as a replacement to antimicrobial growth promoters. The purpose of this study was to evaluate the effects of nucleotide levels on performance, occurrence of diarrhea, relative weight of organs, intestinal histology, and intestinal microbiota of weanling pigs. One hundred and sixty 21-d weaned pigs (6.43 ± 0.71 kg BW) were used in a randomized complete block design experiment with five treatments, eight replications per treatment and four animals per pen (experimental unit). The treatments were basal diet with 120 ppm of chloro-hydroxyquinoline (antimicrobial), and basal diet with 0 (control), 100, 150, or 200 ppm of nucleotides. The average daily gain (ADG), average daily feed intake (ADFI), gain to feed ratio (G:F), and occurrence of diarrhea were calculated from day 1 to 14, day 14 to 34, and day 1 to 34 of the experiment. A day after the end of the experiment, one animal from each pen was slaughtered to evaluate the relative weight of organs, intestinal histology, and intestinal microbiota. From day 1-14 and day 14-34 of the experiment, performance was not affected by the treatments. For the total experimental period (day 1-34), increasing the dietary concentrations of nucleotides linearly improved the final body weight and average daily gain. Salmonella spp. was detected only in the control treatment, without affecting the other microorganisms. Pigs fed with antibiotic had a lower occurrence of diarrhea from day 1-14 compared to pigs fed with nucleotide treatments. Although increasing the occurrence of diarrhea in the first 14 days, dietary nucleotides added up to 200 ppm, improve the final body weight and average daily gain at 34 days post weaning. Nucleotides and antimicrobial not shown beneficial effects on organ weights, and intestinal histology of nursery pig, however, are able to decrease the population of Salmonella spp. at small intestine.

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Section: Resultsmentioning

confidence: 99%

Performance and intestinal health of weanling pigs fed with dietary nucleotides

Andrade

Almeida

Sbardella

et al. 2016

SCA

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“…A Tilosina é um macrolídeo capaz de alterar a microbiota intestinal, seu uso em leitões está relacionado a uma melhora na performance do animal, sobretudo, relacionado ao consumo de ração e conversão alimentar. Um dos mecanismos que podem explicar essa melhora no desempenho corresponde a um aumento na massa relativa de lactobacilos no intestino quando relacionada com as bactérias enterogênicas devido a uma diminuição marcante e permanente destas com o uso deste antibiótico por pelo menos duas semanas (BOSI et al, 2011). Collier et al (2003) demonstraram um maior percentual de lactobacilos na flora intestinal de animais que recebem Tilosina como promotor de crescimento, quando comparados com tratamentos que continham a inclusão de outros aditivos antimicrobianos, atribuindo as melhores taxas de desempenho dos animais a este efeito.…”

Section: Resultsunclassified

Efeito de promotores de crescimento para suínos sobre o desempenho zootécnico, a qualidade intestinal e a eficiência da biodigestão dos dejetos

et al. 2013

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ResumoObjetivou-se avaliar em suínos em fase de crescimento e terminação os efeitos de promotores de crescimento sobre o desempenho, características de carcaça, perfil histológico intestinal, peso dos órgãos do trato digestório, e os reflexos desses tratamentos sobre os efluentes submetidos ao processo de biodigestão. Utilizaram-se 80 suínos, com peso médio inicial de 40,00 ± 1,90 kg, submetidos a quatro tratamentos, durante 61 dias, até atingirem 100,00 ± 4,50kg, correspondendo às dietas: Controle, Simbiótico; Colistina (10ppm); e Tilosina (40ppm). Constatou-se diferença na fase de crescimento, com maior consumo diário de ração para o tratamento Tilosina em relação ao tratamento Colistina. Não houve diferença para as características de carcaça, para o peso dos órgãos e para os parâmetros avaliados no processo de biodigestão dos dejetos (pH, sólidos totais, demanda química de oxigênio e demanda bioquímica de oxigênio). Quanto à morfometria intestinal, os animais do tratamento Tilosina apresentaram maior profundidade de cripta (P≤0,05) no duodeno em relação aos animais dos tratamentos Controle e Simbiótico, assim como maior profundidade de cripta no jejuno (P≤0,05). Houve diferença para a taxa vilosidade/cripta, com o tratamento Controle apresentando maior valor em relação aos demais tratamentos. Para o íleo, houve diferença para a profundidade de cripta dos animais do tratamento Controle em relação ao tratamento Tilosina. Apesar das diferenças observadas para as características de morfometria intestinal, não houve vantagem na utilização dos aditivos para os parâmetros de interesse zootécnico. Quanto aos efeitos sobre a fermentação dos efluentes provenientes dos animais submetidos aos tratamentos, os resultados não indicaram vantagens para nenhum aditivo. Palavras-chave: Antimicrobiano, dejetos, desempenho, simbiótico AbstractThis study aimed to evaluate the effects of growth promoters in growing and finishing pigs on performance and carcass characteristics, intestinal histological profile, organs weight of the digestive tract, and the consequences of these treatments on the effluent through the process of biodigestion. Were used 80 pigs

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“…However, such an increase in food and/or energy intake following antibiotic administration has already been reported for both laboratory and farm animals [16,28] even though the underlying mechanisms are unclear. Interestingly, this increase occurred immediately after full weaning in the current study, namely at a period during which the ATB-treated group still had a distorted microbiota compared to the CTL group.…”

Section: Discussionmentioning

confidence: 99%

Can Antibiotic Treatment in Preweaning Rats Alter Body Composition in Adulthood?

Morel¹,

Oosting²,

Piloquet³

et al. 2013

Neonatology

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Background: It is suggested that antibiotherapy in infancy might program adult body composition and thus could be a determinant of obesity risk. Although not convincingly substantiated by existing literature, this assumption is plausible since antibiotics affect intestinal microbiota, whose composition in adulthood is potentially programmable during infancy and which is able to interact with both fat development and central control of appetite. Objectives: In order to substantiate the link between antibiotherapy and programming of adult body composition, the present study investigated the impact of a course of amoxicillin treatment in neonatal period on subsequent growth and body composition in rats. Methods: Suckling rat pups were treated by oral gavage with an amoxicillin solution (150 mg·kg^–1) or vehicle from postnatal day (PND)5 to PND15. All animals were fully weaned at PND21 then fed a standard diet until PND130. Animal growth and food intake were followed up until PND130, when body composition and plasma leptin were measured. Faecal microbiota was typified at regular intervals using real-time quantitative polymerase chain reaction. Results: Preweaning amoxicillin treatment affected the composition of the faecal microbiota of pups at PND21 but this impact did not sustain long beyond the antibiotic supplementation. Immediately after weaning, a transient increase in food intake (+11%) was noticed in amoxicillin-treated animals. However, no significant impact on either growth or body composition at adulthood was observed. Conclusions: In a neonatal animal model there is no evidence of a programming of adult body weight and composition by wide-spectrum antibiotic treatment in early life.

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Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota1

Cited by 49 publications

References 25 publications

Performance and intestinal health of weanling pigs fed with dietary nucleotides

Performance and intestinal health of weanling pigs fed with dietary nucleotides

Efeito de promotores de crescimento para suínos sobre o desempenho zootécnico, a qualidade intestinal e a eficiência da biodigestão dos dejetos

Can Antibiotic Treatment in Preweaning Rats Alter Body Composition in Adulthood?

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