Feed restriction as a biostimulant of the production of oocyte, their quality and GDF-9 gene expression in rabbit oocytes

Daoud, Niveen M.; Mahrous, Karima F.; Ezzo, O. H.

doi:10.1016/j.anireprosci.2012.09.011

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…This argues against a role of FGF21 excess in driving MAT expansion during CR. In contrast, decreased IGF-1 is well established doi: 10.1210/en.2015-1477 press.endocrine.org/journal/endo 517 during anorexia nervosa in humans (60) and CR in rodents (58), supporting the possibility that this contributes to MAT expansion; however, IGF-1 also decreases during CR in rabbits (87), and therefore, this is unlikely to account for the differences in MAT expansion observed between rabbits and mice. Moreover, CR in non-anorexic humans was recently shown to decrease bone mass without affecting circulating IGF-1 (88), demonstrating that decreased IGF-1 is not necessary for effects of CR on bone.…”

Section: Endocrine Factors As Potential Mediators Of Crassociated Matmentioning

confidence: 98%

Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia

et al. 2015

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Bone marrow adipose tissue (MAT) accounts for up to 70% of bone marrow volume in healthy adults and increases further in clinical conditions of altered skeletal or metabolic function. Perhaps most strikingly, and in stark contrast to white adipose tissue, MAT has been found to increase during caloric restriction (CR) in humans and many other species. Hypoleptinemia may drive MAT expansion during CR but this has not been demonstrated conclusively. Indeed, MAT formation and function are poorly understood; hence, the physiological and pathological roles of MAT remain elusive. We recently revealed that MAT contributes to hyperadiponectinemia and systemic adaptations to CR. To further these observations, we have now performed CR studies in rabbits to determine whether CR affects adiponectin production by MAT. Moderate or extensive CR decreased bone mass, white adipose tissue mass, and circulating leptin but, surprisingly, did not cause hyperadiponectinemia or MAT expansion. Although this unexpected finding limited our subsequent MAT characterization, it demonstrates that during CR, bone loss can occur independently of MAT expansion; increased MAT may be required for hyperadiponectinemia; and hypoleptinemia is not sufficient for MAT expansion. We further investigated this relationship in mice. In females, CR increased MAT without decreasing circulating leptin, suggesting that hypoleptinemia is also not necessary for MAT expansion. Finally, circulating glucocorticoids increased during CR in mice but not rabbits, suggesting that glucocorticoids might drive MAT expansion during CR. These observations provide insights into the causes and consequences of CR-associated MAT expansion, knowledge with potential relevance to health and disease.

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Section: Endocrine Factors As Potential Mediators Of Crassociated Matmentioning

confidence: 98%

Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia

et al. 2015

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“…; Daoud et al. ). The current study shows that does from a line selected by growth rate with feed restriction during rearing might be disadvantaged in terms of oocyte reserve quality or fertilization process that conditioned embryo survival, increasing foetal and gestational losses and limiting foetal growth.…”

Section: Discussionmentioning

confidence: 98%

“…; Daoud et al. ). Moreover, maternal body weight or body condition before or immediately after conception may play a role in foeto‐placental growth in early pregnancy, altering the weight of the foetal membranes and individual foetal weight (MacLaughlin et al.…”

Section: Introductionmentioning

confidence: 98%

“…Although nutritional regimens after mating can have an effect, more data indicate that modifications to the nutritional regimen before mating may have greater impact on embryo survival and uniformity of litter size than the diet after mating (Ashworth et al 1999a,b). Several reports have established that an altered nutritional regimen prior to mating can influence follicular/oocyte characteristics, but also that the maternal diet during pre-implantation development acts as a signalling input to the early embryo to regulate its future growth, as the periimplantation period is a key period for future embryo development (Edwards and McMillen 2002;MacLaughlin et al 2005;Watkins et al 2008;Picone et al 2011;Daoud et al 2012). Moreover, maternal body weight or body condition before or immediately after conception may play a role in foeto-placental growth in early pregnancy, altering the weight of the foetal membranes and individual foetal weight (MacLaughlin et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Female Dietary Restriction in a Rabbit Growth Line During Rearing on Reproductive Performance and Embryo Quality

Naturil-Alfonso

Lavara

Vicente

et al. 2015

Reprod Domestic Animals

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Maternal diet prior to mating has an effect on reproductive performance. We analysed the effect of maternal dietary restriction during rearing on reproductive performance, the embryo development and foetal growth. Females were categorized in two groups: (i) does with ad libitum access to feed or (ii) restricted. Two experiments were performed: (i) after 1 month, receptive females from both experimental groups were artificially inseminated and the reproductive performance was recorded during three reproductive cycles; at the first insemination, the body weight and perirenal fat thickness were recorded, and (ii) females from both experimental groups were inseminated, and 24 h later, embryos were recovered and transferred to recipient females from a maternal line. Later, embryonic implantation was assessed at day 14 by laparoscopy and foetal growth was monitored by ultrasound examination. In experiment 1, no differences in kindling rate was found, but prolificacy was showed to be higher in ad libitum does, which also were heavier than restricted ones. In experiment 2, no differences among does either in body weight, in perirenal fat thickness or in reproductive performance (ovulation rate and embryo recovery rate) were related to differences in feed intake. However, despite similar embryonic implantation losses, embryos from restricted females demonstrated higher foetal and gestational losses. Embryos from restricted does presented lower foetal growth than embryos from ad libitum does. Therefore, our results demonstrated that nutrition before first conception in a rabbit line selected for growth rate may impact on the embryo and results in a disturbance in gestational losses and foetal growth over all reproductive life.

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“…Several reports have established that an altered maternal nutritional regimen prior to mating and during pre-implantation development can influence follicular/ oocyte characteristics and embryo development (Edwards and McMillen, 2002;MacLaughlin et al, 2005;Watkins et al, 2008;Picone et al, 2011;Daoud et al, 2012). In this sense, a restrictive diet during rearing is used to control body condition and prevent the negative effects of over-fattening on fertility and foetal losses (Rommers et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of restricted feeding under rearing on reproduction, body condition and blood metabolites of rabbit does selected for growth rate

et al. 2017

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Young rabbit females selected for growth rate can have nutritional needs which may not be met by the common practice of feed restriction during rearing in commercial rabbit production. The aim of this study was to analyse the effect of two different feeding programmes: restricted and ad libitum feeding, applied in young rabbit females for one month at the end of rearing, on reproductive performance, body condition and circulating metabolic hormones and metabolites in a rabbit line selected by growth rate in 3 consecutive reproductive cycles. Thus, twenty-four 16-week-old does were randomly assigned to a group in which the daily recommended nutrient intakes were satisfied (fed restricted: 130 g/day, n=13) or a group fed to satiety (ad libitum: 235.5 g/day, n=11) during one month. Then, all does were inseminated in 3 consecutive cycles using a 42-day reproductive cycle. Measurements of does' body weight, perirenal fat thickness and plasma leptin, non-esterified-fatty-acids (NEFA), beta-hydroxybutyrate (BOHB) and fructosamine were performed at artificial insemination (AI), parturition and weaning time in 3 consecutive cycles. Reproductive performance of does was evaluated based on fertility, litter size at parturition, prolificacy and productivity. Differences in body weight were found only in the 1 st cycle, ad libitum fed females being heavier than restricted ones. Nevertheless, body weight variances disappeared in later cycles. No differences were found in perirenal fat thickness. Finally, in ad libitum fed females slight differences were found in plasma levels of NEFAs (452 vs. 258 µekv/L and 527 vs. 306 µekv/L for 1 st and 2 nd cycles) and BOHB (0.26 vs. 0.03 mM for 2 nd cycle), but disappeared in the 3 rd reproductive cycle. Fertility, prolificacy and productivity was not significantly affected by the feeding programme. Nevertheless, total litter size showed to be higher in ad libitum fed females at second parturition (8.7 vs. 5.9 kits). Therefore, the evaluated feeding programmes until first AI in females selected by growth rate had no effect on their reproductive outcomes, as the global reproductive performance was not affected.

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Feed restriction as a biostimulant of the production of oocyte, their quality and GDF-9 gene expression in rabbit oocytes

Cited by 19 publications

References 29 publications

Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia

Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia

Effects of Female Dietary Restriction in a Rabbit Growth Line During Rearing on Reproductive Performance and Embryo Quality

Effect of restricted feeding under rearing on reproduction, body condition and blood metabolites of rabbit does selected for growth rate

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