Feed contaminated by fumonisin (Fusarium spp.) in chicks has a negative influence on oxidative stress and performance, and the inclusion of curcumin-loaded nanocapsules minimizes these effects

Galli, Gabriela M.; Griss, Luiz Gustavo; Fortuoso, Bruno F.; Silva, Aniélen D.; Fracasso, Mateus; Lopes, Thalisson F.; Schetinger, Maria Rosa S.; Gündel, Samanta da Silva; Ourique, Aline Ferreira; Carneiro, Christofe; Mendes, Ricardo E.; Boiago, Marcel M.; Silva, Aleksandro S. Da

doi:10.1016/j.micpath.2020.104496

Cited by 10 publications

(5 citation statements)

References 51 publications

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“…These characteristics are the main features of Niemann-PicktypeC1 disease [ 58 ], as well as features for fumonisin poisoning. Feeding chicks with curcumin nanocapsules supplemented with 600 mg/kg fumonisin and 10 mg/kg curcumin, showed protecting protective effects to the liver and an antioxidant effect, as well as reducing the level of thiobarbituric acid active substance in ROS and improving the weight gain of chicks compared with the control group [ 59 ]. Moreover, curcumin reduces PK-15 death in vitro.…”

Section: Detoxification Of Fumonisins Using Biological Antioxidantsmentioning

confidence: 99%

Toxic Mechanism and Biological Detoxification of Fumonisins

Wang

et al. 2022

Toxins

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Food safety is related to the national economy and people’s livelihood. Fumonisins are widely found in animal feed, feed raw materials, and human food. This can not only cause economic losses in animal husbandry but can also have carcinogenicity or teratogenicity and can be left in animal meat, eggs, and milk which may enter the human body and pose a serious threat to human health. Although there are many strategies to prevent fumonisins from entering the food chain, the traditional physical and chemical methods of mycotoxin removal have some disadvantages, such as an unstable effect, large nutrient loss, impact on the palatability of feed, and difficulty in mass production. As a safe, efficient, and environmentally friendly detoxification technology, biological detoxification attracts more and more attention from researchers and is gradually becoming an accepted technique. This work summarizes the toxic mechanism of fumonisins and highlights the advances of fumonisins in the detoxification of biological antioxidants, antagonistic microorganisms, and degradation mechanisms. Finally, the future challenges and focus of the biological control and degradation of fumonisins are discussed.

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Section: Detoxification Of Fumonisins Using Biological Antioxidantsmentioning

confidence: 99%

Toxic Mechanism and Biological Detoxification of Fumonisins

Wang

et al. 2022

Toxins

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“…In another study (Galli et al., 2020), male 1‐day‐old Cobb500 chicks (n = 10/group) were administered a diet containing 0 or 600 mg fumonisin/kg for 10 days. Compared to controls, fumonisin exposure resulted in lower body weight and weight gain, as well as in changes in serum biochemistry such as an increase in cholesterol, uric acid and transaminases.…”

Section: Assessmentmentioning

confidence: 99%

Assessment of information as regards the toxicity of fumonisins for pigs, poultry and horses

Schrenk¹,

Bignami²,

Bodin³

et al. 2022

EFS2

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In 2018, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. A no observed adverse effect level (NOAEL) of 1 mg/kg feed was established for pigs.In poultry a NOAEL of 20 mg/kg feed and in horses a reference point for adverse animal health effect of 8.8 mg/kg feed was established, referred to as NOAEL. The European Commission (EC) requested EFSA to review the information regarding the toxicity of fumonisins for pigs, poultry and horses and to revise, if necessary, the established NOAELs. The EFSA CONTAM Panel considered that the term reference point (RP) for adverse animal health effects better reflects the uncertainties in the available studies. New evidence which had become available since the previous opinion allowed to revise an RP for adverse animal health effects for poultry from 20 mg/kg to 1 mg/kg feed (based on a LOAEL of 2.5 mg/kg feed for reduced intestinal crypt depth) and for horses from 8.8 to 1.0 mg/kg feed (based on case studies on equine leukoencephalomalacia (ELEM)). For pigs, the previously established NOAEL was confirmed as no further studies suitable for deriving an RP for adverse animal health effects could be identified. Based on exposure estimates performed in the previous opinion, the risk of adverse health effects of feeds containing FB1-3 was considered a concern for poultry, when taking into account the RP of 1 mg/kg feed for intestinal effects. For horses and other solipeds, the risk is considered low, although a large uncertainty associated with exposure was identified. The same conclusions apply to the sum of FB1-3 and their hidden forms.

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“…Ledoux et al (1992) demonstrated that FB doses of up to 300 mg/kg feed are needed to trigger clinical toxicity and decreased weight gain in broiler chickens [17]. A decrease in body weight was observed in one-day-old chickens intoxicated with FB at a dose of 600 mg/kg feed [18]. The resulting decrease in body weight following FB administration in various avian species is well described in the literature and said to be a consequence of decreased feed intake and poor feed efficiency [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Intestinal Histomorphometry, the Expression of Intestinal Tight Junction Proteins, and the Bone Structure and Liver of Pre-Laying Hens Following Oral Administration of Fumonisins for 21 Days

Tomaszewska

Rudyk

Dobrowolski

et al. 2021

Toxins

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Fumonisins (FB) are metabolites found in cereal grains (including maize), crop products, and pelleted feed. There is a dearth of information concerning the effects of FB intoxication on the intestinal histomorphometry, the expression of intestinal tight junction proteins, and the bone structure and liver in pre-laying hens. The current experiment was carried out on hens from the 11th to the 14th week of age. The hens were orally administered an extract containing fumonisin B1 (FB1) and fumonisin B2 (FB2) at doses of 0.0 mg/kg b.w. (body weight), 1.0 mg/kg b.w., 4.0 mg/kg b.w., and 10.9 mg/kg b.w. for 21 days. Following FB intoxication, the epithelial integrity of the duodenum and jejunum was disrupted, and dose-dependent degenerative changes were observed in liver. An increased content of immature collagen was observed in the bone tissue of FB-intoxicated birds, indicating intensified bone turnover. A similar effect was observed with regards to the articular cartilage, where enhanced fibrillogenesis was observed mainly in the group of birds that received the FB extract at a dose of 10.9 mg/kg b.w. In conclusion, FB intoxication resulted in negative structural changes in the bone tissue of the hens, which could result in worsened bone mechanics and an increase in the risk of bone fractures. Fumonisin administration, even at a dose of 1.0 mg/kg b.w., can lead to degradation of the intestinal barrier and predispose hens to intestinal disturbances later in life.

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Feed contaminated by fumonisin (Fusarium spp.) in chicks has a negative influence on oxidative stress and performance, and the inclusion of curcumin-loaded nanocapsules minimizes these effects

Cited by 10 publications

References 51 publications

Toxic Mechanism and Biological Detoxification of Fumonisins

Toxic Mechanism and Biological Detoxification of Fumonisins

Assessment of information as regards the toxicity of fumonisins for pigs, poultry and horses

Changes in the Intestinal Histomorphometry, the Expression of Intestinal Tight Junction Proteins, and the Bone Structure and Liver of Pre-Laying Hens Following Oral Administration of Fumonisins for 21 Days

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