Fedratinib-induced orbital inflammation

Gallo, Ryan A.; Vu, Daniel M.; Anagnostopoulos, Apostolos G.; Rong, Andrew J.

doi:10.1080/01676830.2020.1852263

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…[15] Conventional continuous nursing is mainly carried out through telephone follow-up, patient fellowship, health counseling, etc, and the application of "Internet +" makes the mode of continuous nursing more diversified. [16] It has been indicated that most patients are willing to accept appointment nursing services and are willing to pay the related costs. [17] Some scholars have also pointed out that the readmission rate of patients who participate in the hospital's "Internet + Nursing Platform" for nursing appointments is significantly lower, and the medical cost is lower.…”

Section: Discussionmentioning

confidence: 99%

An observation study of the effect of “Internet + Nursing” on psychological status and quality of life of patients with thyroid eye disease

Li,

Sun

2024

Medicine

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“Internet + Nursing” refers to medical institutions using Internet technologies and big data to provide nursing services to discharged patients or those with severe illnesses unable to visit hospitals, through online applications and offline care provision. This study aimed to explore the influence of “Internet + Nursing” on the psychological status and quality of life of patients with thyroid eye disease. Sixty-eight patients with thyroid eye disease from January 2021 to December 2022 were divided into a research group (n = 34, joined the platform) and control group (n = 34, not joined the platform) based on their voluntary participation in our hospital’s “Internet + Nursing Platform.” The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the research group were lower than those of the control group (P < .05). The short form-36 health survey (SF-36) scores in various dimensions were higher in the research group compared to the control group (P < .05). The incidence rates of retinal detachment, vitreous hemorrhage, diabetic retinopathy, and iris neovascularization were lower in the research group compared to the control group (P < .05). After nursing, exophthalmos, blink frequency, and eyelid height of the research group were lower than those of the control group, while tear film breakup time was higher than that of the control group (P < .05). The visual acuity of the research group was higher than that of the control group (P < .05). After nursing, the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ-25) scores in various dimensions were significantly higher in the research group than those in the control group (P < .05). Additionally, after nursing, the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the research group were lower than those in the control group (P < .05). The patients in the research group exhibited higher recognition scores of nursing compared to those in the control group (P < .05). Through the implementation of “Internet + Nursing” for patients with thyroid eye disease discharged from our hospital, we can provide better out-of-hospital nursing for patients, reduce the occurrence of complications, improve ocular surface symptoms, promote visual acuity recovery, and improve patients’ psychological status and quality of life.

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Section: Discussionmentioning

confidence: 99%

An observation study of the effect of “Internet + Nursing” on psychological status and quality of life of patients with thyroid eye disease

Li,

Sun

2024

Medicine

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“…When considering ocular side effects of fedratinib, a comprehensive literature search indicated a case of orbital inflammatory syndrome in one patient that occurred bilaterally following the commencement of fedratinib and resolved upon stopping the medication [ 7 ]. However, there otherwise remains a lack of clinical cases for ophthalmic complications, with no cases describing uveitis as a complication of the drug.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Fedratinib-Associated Uveitis

Evans,

Mathew,

Richardson-May

et al. 2024

Cureus

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Drug-induced uveitis is a rare but important subgroup of uveitis particularly among newer drugs in the market. Establishing a diagnosis can be challenging and requires the physician to have a high index of suspicion and a holistic approach with consideration being afforded to history, clinical examination, and investigations. In this case report, we describe a case of hypopyon uveitis in a 64-year-old male with a background of myelofibrosis for which he was started on fedratinib. A thorough history, negative investigation panel, and temporal association between the start of the drug and uveitis helped establish the diagnosis. A literature review showed no other published cases of uveitis secondary to fedratinib. While he could not be withdrawn from the drug, collaboration with the medical team enabled close monitoring and follow-up. He recovered following a course of steroids and remains under observation.

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