Fecundity genes in sheep

Davis, G. H.

doi:10.1016/j.anireprosci.2004.04.001

Cited by 112 publications

(72 citation statements)

References 12 publications

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“…These include the Wishart line (Davis et al 2006a), a potential second gene in the New Zealand Booroola line ) and the Belle-Ile breed (Davis 2004). However, little is known about the underlying physiology that leads to the observed increases in ovulation rate/litter size or whether any of the aforementioned sheep lines have perturbations in the TGFB superfamily pathway.…”

Section: R113mentioning

confidence: 99%

Using sheep lines with mutations in single genes to better understand ovarian function

Juengel¹,

Davis²,

McNatty³

2013

Reproduction

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Livestock populations have been subjected to strong selection pressure to improve reproductive success, and this has led to the identification of lines of animals with increased fecundity. These animals provide a rich biological resource for discovery of genes and regulatory mechanisms that underpin improved reproductive success. To date, three genes, all related to the transforming growth factor b pathway, have been identified as having mutations that lead to alterations in ovulation in sheep. In addition, several other sheep lines have been identified with putative mutations in single genes with major effects on ovulation rate. This review is focused on the identification of the mutations affecting ovulation rate and how these discoveries have provided new insights into control of ovarian function.Reproduction (2013) 146 R111-R123

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Section: R113mentioning

confidence: 99%

Using sheep lines with mutations in single genes to better understand ovarian function

Juengel¹,

Davis²,

McNatty³

2013

Reproduction

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“…A multipletrait selection index including four component traits (fertility, litter size born, average weaning weight of lambs weaned, ratio of lambs weaned to lambs born or lamb survival) was predicted to result in a 17% greater response in litter weight weaned than direct selection for litter weight weaned (Afolayan et al 2007). Litter size was the most important trait in the index, as its relative contribution to response in total weight weaned was over 90%.…”

Section: Composite V Component Trait Selectionmentioning

confidence: 99%

“…Afolayan et al (2007) predicted that the response to direct selection for total litter weight weaned in crossbred ewes would be 3.17 kg per generation. A lower selection response for total litter weight weaned of 0.32 kg per annum (2.9% annual increase) was predicted by Fogarty et al (1985).…”

Section: Response Of Litter Weight Weaned To Selectionmentioning

confidence: 99%

“…Recently, the trait of interest has been the total weight of lamb(s) weaned per ewe joined or lambing (Ercanbrack and Knight 1985;Lasslo et al 1985;Abdulkhaliq et al 1989;Fogarty 1994;Cloete et al 2004). Litter weight weaned per breeding ewe is an appropriate biological measure of overall ewe reproduction and productivity (Martin and Smith 1980;Ercanbrack and Knight 1998;Snowder 2002;Afolayan et al 2007). All of the component traits of reproduction previously mentioned are expressed in total litter weight weaned.…”

Section: Defining Reproduction and Ewe Productivitymentioning

confidence: 99%

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Composite trait selection to improve reproduction and ewe productivity: a review

Snowder

Fogarty

2009

Anim. Prod. Sci.

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Abstract. Reproduction and ewe productivity are complex composite traits that are influenced by several component traits. Genetic improvement by selection for an individual component trait may not always be advantageous because adverse or neutral genetic relationships can exist among the component traits. Selection for an overall composite trait of ewe productivity, defined as litter weight weaned per ewe joined, can result in a balanced biological composite trait with favourable responses in component traits including fertility, number of lambs born, lamb survival, lactation and lamb growth. Selection for litter weight weaned may also overcome adverse genetic relationships among reproductive component traits. This review examines the genetic responses of selecting directly for litter weight weaned, compared with selection responses for one or more of its component traits. It is concluded that selection to improve reproductive efficiency and ewe productivity, under most production and environmental systems, would benefit from selection for a composite trait such as litter weight weaned, rather than for a single component trait.

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“…In recent years, a number of natural genetic mutations have been associated with ovulation rates in sheep breeds, including one mutation in the BMPR-1B gene (FecB) and ten different mutations in the bone morphogenetic protein 15 [4][5][6] . These mutations are significantly associated with the ovulation rate of different sheep breeds.…”

Section: Introductionmentioning

confidence: 99%

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Dinçel¹,

Ardıçlı²,

Soyudal³

et al. 2015

Kafkas Univ Vet Fak Derg

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Fertility traits, such as the ovulation rate and the number of offspring at birth, are genetically regulated by fecundity genes. This study was performed to identify DNA polymorphisms in Booroola (FecB), Galway (FecX G ), Inverdale (FecX I ) and Calpastatin (CAST) genes in Sakiz sheep. A total of 71 ewes were genotyped for gene or allelic polymorphisms in the genes listed above using the PCR-RFLP method. The results obtained from this study indicated that all of the Sakiz ewes sampled were non-carriers for FecB, FecX G or FecX I mutations. However, genotypic frequencies in the CAST gene were 0.59, 0.36 and 0.05 for AA, AB and BB, respectively. A significant deviation from Hardy-Weinberg equilibrium for the CAST gene was not observed in the investigated breed (P>0.05). As a result, more extensive screening is required as tests for newly discovered mutations are developed. Additionally, this study is the first to report a genetic polymorphism in the CAST gene in Sakiz sheep.

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Fecundity genes in sheep

Cited by 112 publications

References 12 publications

Using sheep lines with mutations in single genes to better understand ovarian function

Using sheep lines with mutations in single genes to better understand ovarian function

Composite trait selection to improve reproduction and ewe productivity: a review

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

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