Fecundability in reproductive aged women at risk of sexual dysfunction and associated risk factors: a prospective preconception cohort study

Loy, See Ling; Ku, Chee Wai; Cheung, Yin Bun; Godfrey, Keith M.; Chong, Yap Seng; Tan, Kok Hian; Yap, Fabian; Bernard, Jonathan Y.; Chen, Helen; Chan, Shiao Yng; Tan, Tse Yeun; Chan, Jerry Kok Yen

doi:10.1186/s12884-021-03892-5

Cited by 8 publications

(3 citation statements)

References 59 publications

(78 reference statements)

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“…To assess their mental health, participants completed the Edinburgh Postnatal Depression Scale (EPDS) and State Trait Anxiety Inventory (STAI) questionnaires. We defined participants with EPDS scores of ≥ 13 as having probable depression, those with scores of >40 for the state anxiety subscale as having probable state anxiety (26).…”

Section: Covariate Assessmentmentioning

confidence: 99%

“…The associations between several preconception exposures (e.g. female adiposity, plasma glycemia and female sexual function) and fecundability has been examined in earlier publications (26,32,33). In this study, only natural conceptions resulting in clinical pregnancies were considered.…”

Section: Dietary Patternsmentioning

confidence: 99%

“…For women who achieved a clinical pregnancy, one more conception cycle was added. Further details on estimating the TTP can be found in previous publications (26,32,33).…”

Section: Dietary Patternsmentioning

confidence: 99%

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Prepregnancy adherence to plant-based diet indices and exploratory dietary patterns in relation to fecundability

Lim

Loy

Colega

et al. 2022

The American Journal of Clinical Nutrition

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Background Modest associations have been reported between specific food groups or nutrients and fecundability [measured by time to pregnancy (TTP)]. Examining overall diets provides a more holistic approach towards understanding the relationships with fecundability. It is not known if plant-based diets indices or exploratory dietary patterns are associated with fecundability. Objective We examine the associations between adherence to 1) plant-based diet indices and 2) exploratory dietary patterns and fecundability among women planning pregnancy. Design Data were analysed from the Singapore S-PRESTO study. Pre-pregnancy diet was assessed using a semi-quantitative food frequency questionnaire from which the overall, healthful and unhealthful plant-based diet indices (oPDI, hPDI and uPDI) were calculated. Exploratory dietary patterns were derived using factor analysis based on forty-four pre-defined food groups. Participants were categorized into quintiles based on their dietary pattern scores. TTP (in menstrual cycles) was ascertained within a year of dietary assessment. Discrete-time proportional hazard models, adjusted for confounders, were used to estimate fecundability ratios (FRs) and 95% CIs, with FR > 1 indicating a shorter TTP. Results Among 805 women, 383 pregnancies confirmed by ultrasound scans occurred. Compared to women in the lowest quintile, those in the highest quintile of the uPDI had reduced fecundability [FR of Q5 vs Q1 (95% CI): 0.65 (0.46, 0.91), p trend: 0.009]. Conversely, greater adherence to the hPDI was associated with increased fecundability [1.46 (1.02, 2.07), p trend: 0.036]. The oPDI was not associated with fecundability. Among the three exploratory dietary patterns, only greater adherence to the “Fast Food and Sweetened Beverages” pattern (FFSB) was associated with reduced fecundability [0.61 (0.40, 0.91), p trend: 0.018]. Conclusions Greater adherence to the uPDI or the FFSB dietary pattern was associated with reduced fecundability among Asian women. Greater adherence to the hPDI may be beneficial for fecundability, though this requires confirmation by future studies. Clinical Trial Registry number: NCT 03531658 Secondary Abstract: Plant-based diets are increasingly popular as they are associated with reduced risks of chronic diseases and considered a sustainable diet for planetary health. Do these diets contribute to fecundability (as measured by time to pregnancy)?

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Section: Covariate Assessmentmentioning

confidence: 99%

Section: Dietary Patternsmentioning

confidence: 99%

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Prepregnancy adherence to plant-based diet indices and exploratory dietary patterns in relation to fecundability

Lim

Loy

Colega

et al. 2022

The American Journal of Clinical Nutrition

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Sexual Function and Mood Disorders Among Menopausal Women: A Systematic Scoping Review

Rahmani

Fedotova

Shahbazi

et al. 2022

The Journal of Sexual Medicine

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Background Changes in sex hormones during menopause may have detrimental effects on a woman’s sexual function and cause mood disorders. The treatment of both conditions is a challenge in gynecology. Aim To review the published literature on sexual function and mood disorders among peri- and postmenopausal women. Methods The review is based on the methodological framework of scoping reviews. We searched electronic databases including Medline (PubMed), Scopus, Embase, and Web of Science (WoS). Publications that reported data about the relationship between sexual function and mood disorders among menopausal women were included in the review. The search was not subject to any limitation in terms of time or method. Outcomes The main outcome measures used for the review were sexual dysfunction and mood disorders. Results We found 106 total records. After a full-text screening we included 19 studies from 1986 to 2020 based on various methodologies; the majority of the studies16 were cross-sectional. Investigations that addressed the symptoms of mood disorders and some domains of sexual function showed a close relationship between sexual dysfunction and mood disorders among menopausal women. Clinical implications In clinical practice, it would be appropriate to screen women for at least one mood disorder or sexual dysfunction. If a woman suffers from either, it will be necessary to assess for a further disorder as well. Strengths & Limitations The review was based on a detailed search of the published literature concerning mood disorders and sexual dysfunction among menopausal women compared to women of reproductive age. Despite the clinical importance of the subject, the number of studies eligible for inclusion in the review are rather small. Further investigation of the topic is clearly warranted. Conclusions While the association between sexual dysfunction and mood disorders appears to be bidirectional, future studies will have to investigate the specific mechanisms by which sexual dysfunction could lead to mood disorders (or vice versa). Future studies should specifically address sexual dysfunctions and attitudes of partners, BMI, family support, sleep, and multiparity.

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Modifiable socioeconomic and lifestyle risk factors for female infertility in Asia: a systematic review from the population health perspective

Chow

Gaskins

et al. 2023

F&S Reviews

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Fecundability in reproductive aged women at risk of sexual dysfunction and associated risk factors: a prospective preconception cohort study

Cited by 8 publications

References 59 publications

Prepregnancy adherence to plant-based diet indices and exploratory dietary patterns in relation to fecundability

Prepregnancy adherence to plant-based diet indices and exploratory dietary patterns in relation to fecundability

Sexual Function and Mood Disorders Among Menopausal Women: A Systematic Scoping Review

Modifiable socioeconomic and lifestyle risk factors for female infertility in Asia: a systematic review from the population health perspective

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