Fecal microbiota transplantation holds the secret to youth

Yang, Meng; Sun, Jing; Zhang, Guirong

doi:10.1016/j.mad.2023.111823

Cited by 7 publications

(2 citation statements)

References 66 publications

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“…С возрастом устойчивое видовое разнообразие микробиоты постепенно снижается, происходят количественные и качественные изменения микробного состава, связанные преимущественно с уменьшением количества бактерий, относящихся к представителям типа Bacteroidetes и рода Bi dobacterium, а также снижением функциональной активности микроорганизмов [5,13] и изменением колонизационной резистентности, что приводит к повышению проницаемости тканевых барьеров и способствует развитию воспаления [14][15]. Интересно отметить, что долгожители характеризуются типом МК, обладающей выраженным «противовоспалительным» потенциалом по сравнению с микробиотой менее пожилых людей, с большей представленностью «полезных» бактерий, синтезирующих масляную кислоту [16].…”

Section: состав и основные функции микробиотыunclassified

Gut Microbiota and (Neuro)Inflammation: Involvement of Endotoxin in the Pathogenesis of Endogenous Psychoses

Zozulya,

Yakovlev,

Klyushnik

2023

Psychiatry

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Background: there is a two-way relationship between the gut microbiota (GM) and the brain, both in normal and pathological conditions. It has been suggested that disturbances in GM composition and function can lead to the activation of (neuro) inflammation or its maintenance in mental disorders. Objective: analysis of scientific publications, including the results of our own research on the gut microbiota, its role in the modulation of brain functions and involvement in the maintenance of (neuro)inflammation in endogenous mental disorders. Material and method: using the keywords “gut–microbiota” and “microbiota–gut–brain axis/mental disorders”, “inflammation”, “neuroinflammation”, articles and reviews were searched in databases and electronic libraries of scientific publications Medline/PubMed, Scopus, Google Scholar, RSCI, and other sources. Results: on the basis of the analysis of literature sources, general information about GM, its composition, functions and main ways of interaction with the brain is given. The role of GM in the development and maintenance of (neuro)inflammation, currently considered as one of the pathogenetic mechanisms of mental disorders, is discussed. Particular attention is paid to the results of own studies on the role of endotoxin (ET) (lipopolysaccharide — LPS) and inflammation in the development of endogenous psychoses and the relationship of these indicators with the effectiveness of pharmacotherapy. Conclusion: it has been established that GM is an important participant and regulator of neuro-immune interactions. The possible role of GM in the maintenance of (neuro)inflammation in endogenous mental disorders and the participation of endotoxin aggression (EA) in the formation of therapeutic resistance in endogenous psychoses were revealed.

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Section: состав и основные функции микробиотыunclassified

Gut Microbiota and (Neuro)Inflammation: Involvement of Endotoxin in the Pathogenesis of Endogenous Psychoses

Zozulya,

Yakovlev,

Klyushnik

2023

Psychiatry

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“…The physiological environment of the gastrointestinal tract and the female reproductive system share similarities, which may contribute to the pathogenesis of enteric and vaginal infections resulting from the proliferation of pathogens (Younes et al, 2018). Fecal microbiota transplantation (FMT) has recently emerged as a dependable and efficacious targeted therapy for gastrointestinal disorders (Meng et al, 2023). Is it achievable to perform vaginal microbiota transplantation (VMT) to directly transfer the entire vaginal microbiota of healthy women to patients, restore the balance of the vaginal microbiota in patients, and enhance their overall health?…”

Section: Introductionmentioning

confidence: 99%

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

Meng,

Sun,

Zhang

2024

Front. Cell. Infect. Microbiol.

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Vaginal microbiota transplantation (VMT) is a cutting-edge treatment modality that has the potential to revolutionize the management of vaginal disorders. The human vagina is a complex and dynamic ecosystem home to a diverse community of microorganisms. These microorganisms play a crucial role in maintaining the health and well-being of the female reproductive system. However, when the balance of this ecosystem is disrupted, it can lead to the development of various vaginal disorders. Conventional treatments, such as antibiotics and antifungal medications, can temporarily relieve the symptoms of vaginal disorders. However, they often fail to address the underlying cause of the problem, which is the disruption of the vaginal microbiota. In recent years, VMT has emerged as a promising therapeutic approach that aims to restore the balance of the vaginal ecosystem. Several studies have demonstrated the safety and efficacy of VMT in treating bacterial vaginosis, recurrent yeast infections, and other vaginal conditions. The procedure has also shown promising results in reducing the risk of sexually transmitted infections and preterm birth in pregnant women. However, more research is needed to establish optimal donor selection, preparation, and screening protocols, as well as long-term safety and efficacy. VMT offers a safe, effective, and minimally invasive treatment option for women with persistent vaginal problems. It could improve the quality of life for millions of women worldwide and become a standard treatment option shortly. With further research and development, it could potentially treat a wide range of other health problems beyond the scope of vaginal disorders.

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A viable remedy for overcoming resistance to anti-PD-1 immunotherapy: Fecal microbiota transplantation

Meng,

Sun,

Zhang

2024

Critical Reviews in Oncology/Hematology

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Fecal microbiota transplantation holds the secret to youth

Cited by 7 publications

References 66 publications

Gut Microbiota and (Neuro)Inflammation: Involvement of Endotoxin in the Pathogenesis of Endogenous Psychoses

Gut Microbiota and (Neuro)Inflammation: Involvement of Endotoxin in the Pathogenesis of Endogenous Psychoses

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

A viable remedy for overcoming resistance to anti-PD-1 immunotherapy: Fecal microbiota transplantation

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