Fecal Microbiota Transplantation for Ulcerative Colitis: FoMenTing Change?

Martins, Flaviano S.

doi:10.1007/s10620-016-4133-2

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…(g) Recording adverse reactions and long‐term effects: it is not known whether FMT could cause other diseases in the long term; therefore, long‐term follow up should be strengthened. (h) Other factors: the effect of bacteria and viruses should not be neglected in the process of microflora transplantation. Individualized treatment: compatibility between donor and recipient, immune tolerance or rejection, completion of individual genomic data and establishment of unique microbiota. Ethical issues securing informed patient consent, selecting donors, screening for infections, and evaluating treatment safety and efficacy.…”

Section: Therapeutic Strategy Of Fmt In Uc and Controversymentioning

confidence: 99%

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment

Guo

Liu

Hao

2020

J of Digest Diseases

173

110

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Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem—based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interactions with gut microbiota. The commensal bacterial community is implicated in the pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC). The dysbiosis of microbes is characterized by reduced biodiversity, abnormal composition of gut microbiota, altered spatial distribution, as well as interactions among microbiota, between different strains of microbiota, and with the host. The defects in microecology, with the related metabolic pathways and molecular mechanisms, play a critical role in the innate immunity of the intestinal mucosa in UC. Fecal microbiota transplantation (FMT) has been used to treat many diseases related to gut microbiota, with the most promising outcome reported in antibiotic‐associated diarrhea, followed by IBD. This review evaluated the results of various reports of FMT in UC. The efficacy of FMT remains highly controversial, and needs to be regularized by integrated management, standardization of procedures, and individualization of treatment.

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