Fecal microbiota transplantation for hepatic encephalopathy: Ready for prime time?

Tandon, Puneeta; Madsen, Karen; Kao, Dina

doi:10.1002/hep.29396

Cited by 5 publications

(3 citation statements)

References 10 publications

(24 reference statements)

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“…The authors concluded that PSAE may improve liver function, decrease PHT, and lower portosystemic shunting in this way to ameliorate neurological symptoms. Intestinal microbiota is closely related to HE, and some studies have reported that fecal microbiota transplantations (FMT) might improve HE[ 23 ]. Based on this, Sun et al [ 24 ] reported a case of HM in a patient who received FMT, and neurological function improved after three repetitions of FMT.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous remission of hepatic myelopathy in a patient with alcoholic cirrhosis: A case report

Chang¹,

Liu²,

Duan³

et al. 2022

World J Clin Cases

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BACKGROUND Hepatic myelopathy (HM) is a rare neurological complication of advanced cirrhosis. Prognosis of patients with HM is generally poor without timely liver transplantation or interventional therapy. Self-resolving HM in patients with alcoholic cirrhosis has never been reported. CASE SUMMARY A 53-year-old man with alcoholic cirrhosis and recurrent overt hepatic encephalopathy for 1 year was admitted for lower extremity weakness, slow movement, and stumbling gait. The patient was diagnosed with HM after excluding other causes of spastic paraparesis. The patient refused liver transplantation. However, the patient kept total abstinence and received a multidisciplinary treatment for complications of decompensated cirrhosis. The symptoms of HM resolved gradually after 2 years of treatment. All complications of alcoholic cirrhosis resolved after 4 years of follow-up. CONCLUSION The case demonstrates that HM can resolve in patients without liver transplan-tation after total abstinence and systemic management of complications.

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Section: Discussionmentioning

confidence: 99%

Spontaneous remission of hepatic myelopathy in a patient with alcoholic cirrhosis: A case report

Chang¹,

Liu²,

Duan³

et al. 2022

World J Clin Cases

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“…Subsequently, FMT has continued to flourish, with a wider range of indications. [29][30][31][32][33][34] With the progressive development of FMT, its limitations have become clearer; these limitations are as follows. 35,36 1) For the safety of patients undergoing FMT, strict expert consensus guidelines are used to guide donor selection; the process is complex and involves considerable effort (e.g., health and medical screening, especially regarding a history of temporary or permanent intestinal dysbacteriosis; serologic screening; and conventional detection.…”

Section: Discussionmentioning

confidence: 99%

Composition of “gold juice” using an ancient method based on intestinal microecology

Guo

Wang

et al. 2020

J Int Med Res

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Objective To identify potentially effective bacterial components of gold juice, a traditional Chinese medicine treatment used for fecal microbiota transplantation. Methods Fecal samples were collected from five healthy children (two boys and three girls; mean age, 7.52 ± 2.31 years). The children had no history of antibiotic use or intestinal microecological preparation in the preceding 3 months. Fresh fecal samples were collected from children to prepare gold juice in mid-to-late November, in accordance with traditional Chinese medicine methods, then used within 7 days. Finally, 16S rDNA sequence analysis was used to identify potentially effective bacterial components of gold juice. QIIME software was used for comparisons of microbial species among gold juice, diluent, filtrate, and loess samples. Results Microflora of gold juice exhibited considerable changes following “ancient method” processing. Microbial components significantly differed between gold juice and filtrate samples. The gold juice analyzed in our study consisted of microbes that synthesize carbohydrates and amino acids by degrading substances, whereas the filtrate contained probiotic flora, Bacteroides, and Prevotella 9. Conclusions This study of microbial components in gold juice and filtrate provided evidence regarding effective bacterial components in gold juice, which may aid in clinical decisions concerning fecal microbiota transplantation.

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“…Extensive studies on the microbiome and eventually FMT as a therapeutic strategy have been performed for other diseases, including metabolic diseases (Groen and Nieuwdorp, 2017; Zhang et al, 2017), diabetes mellitus (van Olden et al, 2015), obesity and non-alcoholic liver disease (Abdou et al, 2016; de Clercq et al, 2016; Marotz and Zarrinpar, 2016; Reijnders et al, 2016; Tandon et al, 2017; Nobili et al, 2018), HIV (Vujkovic-Cvijin et al, 2017; Sessa et al, 2019), and autism spectrum disorders (Kang et al, 2017), with initial but promising results in terms of microbiota profiling and clinical outcomes. The use of FMT in the fields of hematology and oncology, specifically HSCT, has also gained interest.…”

Section: Conveying the Present To The Future For Fighting Against Antmentioning

confidence: 99%

Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization: Present and Future Perspectives

et al. 2019

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The emergence of antimicrobial resistance (AMR) is of great concern to global public health. Treatment of multi-drug resistant (MDR) infections is a major clinical challenge: the increase in antibiotic resistance leads to a greater risk of therapeutic failure, relapses, longer hospitalizations, and worse clinical outcomes. Currently, there are no validated treatments for many MDR or pandrug-resistant (PDR) infections, and preventing the spread of these pathogens through hospital infection control procedures and antimicrobial stewardship programs is often the only tool available to healthcare providers. Therefore, new solutions to control the colonization of MDR pathogens are urgently needed. In this narrative review, we discuss current knowledge of microbiota-mediated mechanisms of AMR and strategies for MDR colonization control. We focus particularly on fecal microbiota transplantation for MDR intestinal decolonization and report updated literature on its current clinical use.

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Fecal microbiota transplantation for hepatic encephalopathy: Ready for prime time?

Cited by 5 publications

References 10 publications

Spontaneous remission of hepatic myelopathy in a patient with alcoholic cirrhosis: A case report

Spontaneous remission of hepatic myelopathy in a patient with alcoholic cirrhosis: A case report

Composition of “gold juice” using an ancient method based on intestinal microecology

Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization: Present and Future Perspectives

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