Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis (MS)

Adverse events in faecal microbiota transplant: a review of the literature

“…cases it was noted only that two had 5 FMTs with the method not recorded and a third had 10 days of FMT infusions. (112) There were no reported adverse events in any of these studies.…”

“…FMT as a treatment for constipation has been described in 7 patients. (105,112) The route of administration was described in 4 cases and included two cases that had their FMT as a colonoscopic procedure followed by 9 enemas. One patient had 15 enemas as daily infusions, and another had a regimen that consisted of colonoscopic FMT followed by 5 combined nasojejunal infusions and enemas followed by a further 5 enemas.…”

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

“…Use of FMT has not been confined to gastrointestinal disease, the single blinded study of Vrie et al 54 with an autologous transplantation for metabolic syndrome opens the door for FMT in treatment of nongastrointestinal disease. There are preliminary reports on the use of FMT therapy in a wide range of disorders including Parkinson's disease, 53 fibromyalgia, chronic fatigue syndrome, 56 multiple sclerosis, 48 myoclonus dystonia, 49 obesity, 70 insulin resistance and the metabolic syndrome, 54 and childhood regressive autism. 51 We need to recognise FMT as a form of organ transplantation.…”

“…44 treated at least 12 patients with chronic constipation in adults and children (Table 4). [44][45][46][47][48] Outcomes treatment of nongastrointestinal diseases in adults and children Several reports described patients with autoimmune and neurologic disorders who showed improvement with FMT therapy (Table 4). One report described the co-development of myoclonus dystonia and chronic diarrhoea in a patient who was subsequently treated with FMT therapy, resulting in 90% improvement of her myoclonus dystonia symptoms, allowing her to resume employment and execute fine motor tasks.…”

The Gastrointestinal Microbiome: A Review

“…[180][181][182] There are also reports of clinical improvement after FMT in humans with IBD, multiple sclerosis, myoclonus dystonia, and refractory ulcerative colitis. 23,183 A double-blind, randomized controlled trial of FMT in 18 men with metabolic syndrome used autologous feces as the control and donor feces from lean men for the treatment arm. 184 The treatment group had improvement in insulin sensitivity and increases in butyrate-producing bacteria after 6 weeks of weekly infusion compared with the control group.…”