Fecal Microbiota Transplant for Clostridium difficile Colitis–Induced Toxic Megacolon

Systematic review with meta‐analysis: faecal microbiota transplantation for the induction of remission for active ulcerative colitis

“…In recent years, faecal microbiota transplant (FMT) has been proven to be extremely effective for treatment of recurrent or refractory Clostridium difficile infection (CDI) . This has encouraged research in FMT as a potential therapy for other microbial‐related diseases such as UC.…”

Successful treatment of fulminant Clostridioides difficile infection with emergent fecal microbiota transplantation in a patient with acute myeloid leukemia and prolonged, severe neutropenia

“…Vancomycin rectal enemas and tigecycline are also considered as adjunctive therapy in some clinical settings . Several case reports describe the use of FMT in the treatment of fulminant CDI for immunocompetent patients; however, findings from our patient expand the literature due to the degree of immunosuppression and acuity of critical illness, which necessitated an aggressive salvage approach to bridge the patient to stem cell transplant …”

“…1 Several case reports describe the use of FMT in the treatment of fulminant CDI for immunocompetent patients; however, findings from our patient expand the literature due to the degree of immunosuppression and acuity of critical illness, which necessitated an aggressive salvage approach to bridge the patient to stem cell transplant. 4,5 The use of FMT for the treatment of fulminant CDI in immunocompromised populations, particularly those with hematological malignancies, remains limited (Table 1). In one small case series that excluded patients with fulminant disease, patients with hematological malignancies had successful treatment of recurrent CDI with FMT.…”

Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead

“…We have previously urged physicians to implement FMT before the fulminant stage to minimize patient suffering, morbidity and mortality and healthcare-related costs [9]. However, FMT has now been successfully employed in a handful of acute, severe and fulminant CDI cases [12,14,[45][46][47][48]. In fact, the first published case series of FMT was in (what we now know to be) refractory pseudomembranous colitis by Eiseman et al (1958) [10].…”