Fecal microbiota in pediatric depression and its relation to bowel habits

Zhou, Yuanyue; Zhang, Xue; Pan, Liya; Zhang, Wen-wu; Chen, Fang; Hu, Shiqian; Jiang, Hai‐yin

doi:10.1016/j.jpsychires.2022.03.037

Cited by 11 publications

(25 citation statements)

References 43 publications

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“…Several studies examining the role of intestinal microbiota in adult depression have already been published, while three of them evaluated its potential role in adolescent depression [ 18 , 94 , 95 ]. There are no consistent findings about alpha and beta diversity differences between patients with depression and healthy controls in these studies.…”

Section: Resultsmentioning

confidence: 99%

“…Thapa et al (2021) failed to find statistically significant differences in the abundance of the main bacterial phyla and genera in MDD patients [ 18 ]. In contrast, two other articles brought the evidence of several differences in gut bacteria between patients and healthy controls [ 94 , 95 ]. Among 26 significantly increased bacterial genera, Ling et al (2022) identified eight bacterial taxa to be the biomarkers of childhood depression ( Prevotella , Bifidobacterium , Eischerichia/Shigella , Agathobacter, Gemmiger , Streptococcus, Collinsella , and Klebsiella) from which Streptococcus was the best predictor for MDD in children [ 94 ].…”

Section: Resultsmentioning

confidence: 99%

“…Previously published studies on adult depression found negative correlation between the abundance of Bacteroides and Faecalibacterium and the severity of depressive symptoms [ 96 , 97 ]. However, inconsistently with these findings, Zhou et al (2022) described enriched populations of Bacteroides in children with depression [ 95 ]. Enriched Eischerichia/Shigella and unclassified_f_Enterobacteriaceae were positively correlated with anxiety and depressive scores in the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, inconsistently with these findings, Zhou et al (2022) described enriched populations of Bacteroides in children with depression [ 95 ]. Enriched Eischerichia/Shigella and unclassified_f_Enterobacteriaceae were positively correlated with anxiety and depressive scores in the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) [ 95 ]. Likewise, the abundances of Faecalibacterium and Bacteroides were similar between the patients and the healthy control group in the study of Thapa et al (2021) [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…In depression, Faecalibacterium had decreased abundance in adults [ 107 ], and in children [ 94 ], and Streptococcus genera were increased in both groups [ 94 , 108 ]. Parabacteroides and Alistipes had increased levels in adults [ 109 ], but decreased levels in children [ 94 , 95 ], while Lactobacillus and Eggerthella were elevated in adults but not changed in children [ 109 ].…”

Section: Discussionmentioning

confidence: 99%

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Gut Microbiota Profiles in Children and Adolescents with Psychiatric Disorders

2022

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The aim of our work is to summarize the current state of knowledge on gut microbiota differences in children and adolescents with psychiatric disorders. To find the relevant articles, the PubMed, Web of Science, and Google Scholar databases were searched. Articles in English presenting original data and comparing the composition of gut microbiota in child psychiatric patients with gut microbiota in healthy children and adolescents were selected. Finally, we identified 55 articles eligible for our purpose. The majority of patients with autism spectrum disorders (ASD) were investigated. A smaller number of studies evaluating the gut microbiota in children and adolescents with attention-deficit/hyperactivity disorder (ADHD), Rett syndrome, anorexia nervosa, depressive disorder (DD), and tic disorders were found. The main findings of this research are discussed in our review, focusing on the age-related gut microbiota specificity for psychiatric disorders and the differences between individual diagnosis. To conclude, the gut microbiota in children and adolescents with psychiatric disorders is evidently different from that in controls. The most pronounced differences are seen in children with ASD, less in ADHD. Moreover, the changes are not identical to those in adult psychiatric patients, as Ruminococcus, Turicibacter, and Bilophila were increased in adults, and decreased in children with ASD, and Parabacteroides and Alistipes were more frequently represented in adults, but less frequently represented in children with depression. The available data suggest some genera have a different abundance in individual psychiatric disorders (e.g., Bilophila, Bifidobacterium, Clostridium, Coprococcus, Faecalibacterium, and Ruminococcus), suggesting their importance for the gut–brain axis. Other bacterial genera might be more important for the pathophysiology of specific disorder in children and adolescents, as Akkermansia and Desulfovibrio for ASD, or Romboutsia for DD. Based on the research findings, we assume that gut microbiota corrections have the potential to improve clinical symptoms in psychiatric patients.

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Section: Resultsmentioning

confidence: 99%