Fecal Level of Calprotectin Identifies Histologic Inflammation in Patients With Ulcerative Colitis in Clinical and Endoscopic Remission

Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation

“…On the contrary, residual low-grade histological inflammation is often found in the colonic mucosa of UC patients even after they show clinical and endoscopic remission [53], which might be associated with the development of IBS-like symptoms. Recently, Henriksen et al [37] investigated the influence of histological inflammation on the prevalence of IBS-like symptoms in UC patients with endoscopic evidence of remission and lower FC levels.…”

Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis—the ACERTIVE study

“…Interestingly, Guardiola et al 32 have recently proposed that an FC concentration lower than 155 μg/g can indicate the absence of acute inflammatory infiltrate with a NPV of 89% in UC patients considered to be in clinical and endoscopic remission. Our study validates and expands this previous report, using a much larger cohort (371 vs.…”

High Within-day Variability of Fecal Calprotectin Levels in Patients with Active Ulcerative Colitis

“…FC is a useful tool for patients in clinical remission because it has proved to be accurate in predicting UC relapse 1 and to have a good correlation with endoscopic 2 and histological remission, 3 allowing for the identification of patients at risk for clinical relapse and the avoidance of endoscopic examination in certain clinical situations.…”