Fecal Helicobacter pylori glmM and 16S rRNA genes correlate with serum TNF-α and IL-1β cytokine fluctuations

Moradipour, Ayat; Khosravi, Afra; Piri, Fatemeh

doi:10.1556/030.65.2018.030

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…It has been long known that TNF-α is significantly higher in patients with H. pylori infection than in healthy controls, as well as in those with histologically demonstrated gastritis and peptic ulcers, suggesting that it might contribute to the gastric injuries caused by this infection [98]. Recent findings also verified this statement [96]. The expression of TNF-α is correlated with the bacterial load according to Mansilla-Vivar et al, who pointed out that this cytokine is significantly higher in H.-pylori-positive patients without nodular gastritis, which is a well-known sign of increased bacterial load, than in those with nodular gastritis caused by H. pylori infection [48].…”

Section: Tnf-αmentioning

confidence: 78%

“…TNF-α is mainly involved in mediating the acute inflammatory responses to Gram-negative bacteria, along with other infectious agents, where it is responsible for a wide spectrum of complications. Therefore, this cytokine mediates the inflammatory responses during infection with H. pylori as a result of the stimulating effect of H. pylori lipopolysaccharide on macrophages, leading to the synthesis of a great amount of TNF-α [ 96 ]. Furthermore, TNF-α acts as both a recruitment and an activator factor for monocytes, macrophages and neutrophils by stimulating their migration to the infection site [ 97 ].…”

Section: The Trialogue Between H Pylori Cytokines...mentioning

confidence: 99%

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Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer

Meliţ

Mărginean

2022

Children

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H. pylori is involved in the development of 80% of gastric cancers and 5.5% of all malignant conditions worldwide. Its persistence within the host’s stomach causes chronic inflammation, which is a well-known hallmark of carcinogenesis. A wide range of cytokines was reported to be involved in the initiation and long-term persistence of this local and systemic inflammation. IL-8 was among the first cytokines described to be increased in patients with H. pylori infection. Although, this cytokine was initially identified to exert a chemoattracting effect that represents a trigger for the activation of inflammatory cells within H.-pylori-infected mucosa, more recent studies failed in encountering any association between IL-8 and H. pylori infection. IL-6 is a multifunctional, pleiotropic and multipotent cytokine involved in mediating the interaction between innate and adaptive immunity with a dichotomous role acting as both a proinflammatory and an anti-inflammatory cytokine depending on the signaling pathway. IL-1α functions as a promoter of angiogenesis and vascular endothelial cell proliferation in gastric carcinoma since it is closely related to H.-pylori-induced inflammation in children. IL-1β is an essential trigger and enhancer of inflammation. The association between a low IL-1β level and an increased TNF-α level might be considered a risk factor for peptic ulcer disease in the setting of H. pylori infection. IL-10 downregulates both cytotoxic inflammatory responses and cell-mediated immune responses. H. pylori uses the immunosuppressive role of IL-10 to favor its escape from the host’s immune system. TGFβ is a continuous inflammatory mediator that promotes the adherence of H. pylori to the host’s cells and their subsequent colonization. The role of H.-pylori-induced inflammatory responses in the onset of gastric carcinogenesis seems to represent the missing puzzle piece for designing effective preventive and therapeutic strategies in patients with H.-pylori-associated gastric cancer.

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Section: Tnf-αmentioning

confidence: 78%

Section: The Trialogue Between H Pylori Cytokines...mentioning

confidence: 99%

Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer

Meliţ

Mărginean

2022

Children

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“…In this pathway,Asymmetric dimethylarginine (ADMA) was the most noticeable metabolism which attracted us. ADMA is an endogenous nitric oxide synthase inhibitor and is associated with endothelial dysfunction, it plays a key role in CVD pathogenesis and atherosclerosis progression ( 25 ). Furthermore, ADMA upregulation is an important and independent risk factor for various CVDs ( 26 ).…”

Section: Resultsmentioning

confidence: 99%

Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model

Zhao

Wang

et al. 2023

Front. Cardiovasc. Med.

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AimsWe assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites.MethodsAn acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed via 16S rRNA gene sequencing. Metabolomics was used to determine fecal metabolites and elucidate the modes of action of HJ11 in acute coronary syndrome treatment.ResultsHJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera norank_f__Ruminococcaceae, Desulfovibrio, Clostridium_sensu_stricto_1, Adlercreutzia, Staphylococcus, Bacteroides, Prevotella, Rikenellaceae_RC9_gut_group, unclassified_o__Bacteroidales, and Ruminococcus_gauvreauii_group. We found 23 differentially expressed intestinal metabolites, and the enriched metabolic pathways were mainly related to amino acid metabolism. We also discovered that asymmetric dimethylarginine levels were strongly associated with cardiovascular disease. Correlation analyses revealed strong associations among intestinal microflora, their metabolites, proinflammatory factors, and cardiac function. Hence, the therapeutic effects of HJ11 on acute coronary syndrome are related to specific alterations in gut microbiota and their metabolites.ConclusionThis work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (Bacteroides and Rikenellaceae_RC9_gut_group), mitigate the risk factors associated with cardiovascular disease, alter bacterial metabolites, lower asymmetric dimethylarginine levels, and effectively treat acute coronary syndrome.

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“…It has been confirmed that GLMM and 16S rRNA in the feces of HP infected subjects were positively related to plasma levels of TNF-α and IL-1. 28 Finally, HP infection can aggravate the metabolic disorder of subjects with DM and increase the risk factors of arteriosclerosis. 29…”

Section: Discussionmentioning

confidence: 99%

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

Yang

Liu

et al. 2020

Diabetes and Vascular Disease Research

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Purpose: This study was conducted to investigate the relation of HP infection to peripheral arterial stiffness and 10-year cardiovascular risk in diabetes mellitus (DM). Methods: DM subjects who underwent the C13-breath test were enrolled and divided into DMHP+ and DMHP− groups. Peripheral arterial stiffness was measured using brachial to ankle pulse wave velocity (baPWV). Framingham score (FRS) and Chinese evaluation method of ischemic cardiovascular diseases (ICVD) were used to clarify 10-year cardiovascular risk. Results: A total of 6767 subjects were included, baPWV and proportion of subjects with severe peripheral arterial stiffness were lower in DMHP− group than DMHP+ group (1556.68 ± 227.54 vs 2031.61 ± 525.48 cm/s, p < 0.01; 21.9% vs 62.7%, p < 0.01). Multivariate logistic regression analysis demonstrated that HP infection was independently associated with baPWV. Furthermore, cardiovascular risk score and the proportion of subjects with high risk were lower in DMHP− group than DMHP+ group (FRS: 12.09 ± 3.77 vs 13.91 ± 3.77, 17.2% vs 38.8%; ICVD: 8.56 ± 2.99 vs 10.22 ± 3.16, 43.9% vs 65.4%, with all p < 0.05). Conclusion: DM subjects with HP infection had more severe peripheral arterial stiffness compared those without HP infection, a higher cardiovascular risk score and 10-year cardiovascular risk stratification were observed in those subjects.

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Fecal Helicobacter pylori glmM and 16S rRNA genes correlate with serum TNF-α and IL-1β cytokine fluctuations

Cited by 9 publications

References 26 publications

Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer

Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer

Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model

Relation of Helicobacter pylori infection to peripheral arterial stiffness and 10-year cardiovascular risk in subjects with diabetes mellitus

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