Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer

Song, Eun Mi; Byeon, Jeong‐Sik; Lee, Sun Mi; Yoo, Hyun Ju; Kim, Su Jung; Lee, Sun-Ho; Chang, Kyung Hwan; Hwang, Sung Wook; Jeong, Jin‐Yong

doi:10.1007/s10620-018-4982-y

Cited by 35 publications

(47 citation statements)

References 37 publications

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“…Few studies have demonstrated the potential to discriminate CRC and AA from controls based on faecal VOC analysis [11–15]. The current study outcomes are in line with this literature.…”

Section: Resultssupporting

confidence: 87%

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Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

et al. 2020

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Aim Early detection and removal of colorectal cancer (CRC) and advanced adenomas (AAs) decreases the incidence of and mortality from the disease. We aimed to evaluate the potential of faecal volatile organic compounds (VOCs) for detection and follow-up of colorectal adenoma using advanced electronic nose technology. Method This was a prospective multi-centre case-control cohort including two district hospitals and one tertiary referral hospital. Patients undergoing colonoscopy were instructed to collect a faecal sample prior to bowel cleansing and were included in the study when CRC, AAs, large adenomas (LAs; 0.5-1.0 cm), small adenomas (SAs; 0.1-0.5 cm) or no endoscopic abnormalities (controls) were observed. Patients undergoing polypectomy and controls were asked for a second sample after 3 months. Faecal VOCs were measured with gas chromatography-ion mobility spectrometry. Random forest, support vector machine, Gaussian process and neural net classification were used to evaluate accuracy. Results In total, 14 patients with CRC, 64 with AAs, 69 with LAs, 127 with SAs and 227 controls were included. A second sample was collected from 32 polypectomy patients and 32 controls. Faecal VOCs discriminated CRC and adenomas from control [AUC (95% CI): CRC vs control 0.96 (0.89-1); AA vs control 0.96 (0.93-1); LA vs control 0.96 (0.92-0.99); SA vs control 0.96 (0.94-0.99)]. There were no significant differences between CRC and adenoma groups. Patients with adenomas and controls were discriminated prior to polypectomy, whereas 3 months after polypectomy VOC profiles were similar [T0 adenoma vs control 0.98 (0.95-1); T1 adenoma vs control 0.55 (0.40-0.69)]. Conclusions Faecal VOC profiles may be useful for early detection of CRC and adenomas and the timing of polyp surveillance as polypectomy led to a normalization of the VOC profile.

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“…Few studies have demonstrated the potential to discriminate CRC and AA from controls based on faecal VOC analysis [11–15]. The current study outcomes are in line with this literature.…”

Section: Resultssupporting

confidence: 87%

“…For AA, sensitivity and specificity values were 17.0% and 95.1% for 40 µg/g and 33.0% and 88.0% for 10 µg/g, respectively. Replacing colonoscopy with FIT would reduce colonoscopies by 71%, but would lead to 30-40% [11][12][13][14][15]. The current study outcomes are in line with this literature.…”

Section: Discussionsupporting

confidence: 85%

Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

et al. 2020

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“…The sensitivity was 86% and the specificity was 83%. The AUROC value for this PNN model was 0.852 [ 47 ].…”

Section: Studies On Colorectal Cancer Metabolic Biomarkersmentioning

confidence: 99%

“…When comparing the FU and healthy control groups with a set of those 31 biomarkers, a sensitivity of 100%, a specificity of 96.36%, an accuracy of 97.70% and an AUC of 0.992 were noted. A total of 11 VOCs were common to the previous study [ 47 ] and the PNN analysis using only them, resulted in discrimination of follow-up from CRC patients before surgery with a sensitivity of 100%, a specificity of 97.92%, an accuracy of 98.75%, and an AUC of one. Moreover, the FU group was distinguished from the healthy group which showed a sensitivity of 100%, a specificity of 90.91%, an accuracy of 94.25%, and an AUC of 0.959 [ 50 ].…”

Section: Studies On Colorectal Cancer Metabolic Biomarkersmentioning

confidence: 99%

“…The researchers used a sample collection protocol based on the vital capacity expiration instead of prioritizing obtaining alveolar breath. This procedure can increase the influence of exogenous compounds in breath composition, however, it is a more comfortable and reachable approach for patients [ 47 ]. Depalma et al, 2014, were able to differentiate between patients with polyps and patients with CRC.…”

Section: Studies On Colorectal Cancer Metabolic Biomarkersmentioning

confidence: 99%

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A Review of GC-Based Analysis of Non-Invasive Biomarkers of Colorectal Cancer and Related Pathways

Monedeiro

Monedeiro-Milanowski

Ligor

et al. 2020

JCM

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. In Europe, it is the second most common cause of cancer-related deaths. With the advent of metabolomics approaches, studies regarding the investigation of metabolite profiles related to CRC have been conducted, aiming to serve as a tool for early diagnosis. In order to provide further information about the current status of this field of research, 21 studies were systematically reviewed, regarding their main findings and analytical aspects. A special focus was given to the employment of matrices obtained non-invasively and the use of gas chromatography as the analytical platform. The relationship between the reported volatile and non-volatile biomarkers and CRC-related metabolic alterations was also explored, demonstrating that many of these metabolites are connected with biochemical pathways proven to be involved in carcinogenesis. The most commonly reported CRC indicators were hydrocarbons, aldehydes, amino acids and short-chain fatty acids. These potential biomarkers can be associated with both human and bacterial pathways and the analysis based on such species has the potential to be applied in the clinical practice as a low-cost screening method.

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Lipidomic study and diagnosis of hepatocellular carcinoma tumor with rapid evaporative ionization mass spectrometry

Wang

Shen

et al. 2023

Electrophoresis

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Liver cancer is generally considered the leading cause of cancer deaths worldwide, and hepatocellular carcinoma (HCC) contributes to more than 90% of liver cancers. The altered lipid metabolism for rapid cancer cell growth and tumor formation has been frequently proven. In this study, an ambient ionization mass spectrometry technique, rapid evaporative ionization mass spectrometry (REIMS) using a monopolar electric knife, called iKnife, was systematically optimized and employed for ex vivo analysis of 12 human HCC tumor tissue specimens together with the paired paracancerous tissue (PT) and noncancerous liver tissue (NCT) specimens. Nine free fatty acids and 34 phospholipids were tentatively identified according to their extract masses and/or tandem mass spectra. With the help of statistical methods, 7 free fatty acids and 10 phospholipids were distributed differently in 3 types of liver tissue specimens (95% confidence interval). The box plots showed these characterized lipid metabolites varied in PT, HCC, and NCT. Compared with PT and NCT, the upregulations of four common fatty acids FA 18:0,

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Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer

Abstract: There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC.

Cited by 35 publications

References 37 publications

Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

A Review of GC-Based Analysis of Non-Invasive Biomarkers of Colorectal Cancer and Related Pathways

Lipidomic study and diagnosis of hepatocellular carcinoma tumor with rapid evaporative ionization mass spectrometry

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