Fecal elastase 1, serum amylase and lipase levels in children with cholestasis

Wen, Wan–Hsin; Chen, Huey‐Ling; Chang, Mei–Hwei; Ni, Yen‐Hsuan; Shih, Hsiang-Hung; Lai, Hong‐Shiee; Hsu, Wen-Ming

doi:10.1159/000086545

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Wen et al assessed both FE1 concentrations and FL activities in stool and did not find any abnormalities. However, their study consisted of exclusively four subjects with AGS 9 . Therefore, in our research, we aimed to assess the exocrine pancreatic function of a larger subset of AGS subjects using the generally accepted indirect pancreatic test (FE1) as well as measuring lipase output.…”

Section: Discussionmentioning

confidence: 99%

Exocrine pancreatic function in children with Alagille syndrome

Gliwicz

Jankowska

Wierzbicka

et al. 2016

Sci Rep

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Alagille syndrome (AGS) is often associated with symptoms of maldigestion, such as steatorrhea, hypotrophy and growth retardation. Exocrine pancreatic insufficiency was proposed as the underlying cause. We aimed to assess the exocrine pancreatic function with the use of different methods in AGS patients. Concentrations of fecal elastase-1 (FE1) and fecal lipase (FL) activities were measured in 33 children with AGS. The C-mixed triglyceride breath test (MTBT) in a subgroup comprising 15 patients. In all patients studied, FE1 concentrations and FL activities were normal. Abnormal MTBT results were documented in 4 (26.7%) patients. The FE1 and FL levels in MTBT-positive and MTBT-negative children did not differ. The results of this research do not confirm the presence of exocrine pancreatic dysfunction in AGS patients. Routine screening for exocrine pancreatic insufficiency of this group of patients is not necessary.

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Section: Discussionmentioning

confidence: 99%

Exocrine pancreatic function in children with Alagille syndrome

Gliwicz

Jankowska

Wierzbicka

et al. 2016

Sci Rep

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“…Wen et al [16] recently reported fecal elastase concentrations, and serum and lipase levels, in a group of patients with cholestasis. However, no information on fecal fat excretion was given.…”

Section: Patients Sex Age (Years)mentioning

confidence: 99%

Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1

Walkowiak

Jankowska

Pawłowska

et al. 2006

Scandinavian Journal of Gastroenterology

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Significant elevations of serum lipase not caused by pancreatitis: a systematic review

Hameed

Lam

Pleass

2015

HPB

100

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A series of differential diagnoses for significant serum lipase elevations (i.e. exceeding three times the ULN) has been provided by this study. Clinicians should utilize this knowledge in the interpretation and management of patients who have lipase levels over three times as high as the ULN, remaining vigilant for an alternative diagnosis to pancreatitis. The medical officer should be aware of the possibility of incorrect diagnosis in the asymptomatic patient.

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Fecal elastase 1, serum amylase and lipase levels in children with cholestasis

Cited by 5 publications

References 23 publications

Exocrine pancreatic function in children with Alagille syndrome

Exocrine pancreatic function in children with Alagille syndrome

Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1

Significant elevations of serum lipase not caused by pancreatitis: a systematic review

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