Fecal calprotectin levels are increased in infants with necrotizing enterocolitis

Aydemir, Özge; Aydemir, Cumhur; Sarikabadayi, Yusuf Unal; Canpolat, Fuat Emre; Erdeve, Ömer; Biyikli, Zeynep; Dilmen, Uğur

doi:10.3109/14767058.2012.684172

Cited by 52 publications

(46 citation statements)

References 23 publications

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“…64 Thirty-one neonates with mild enteropathy displayed median (range) FCs of 393 (52-996) µg/g compared to those with severe enteropathy, 832 (168-4775) µg/g, including patients with NEC Stage IIb and III. 65 These results are consistent with those from OR Herrera, et al recent studies that observed higher FC concentrations in preterm infants with NEC compared to controls 66 and were linked with disease severity. 67 I-FABP may be another marker that correlates well with extent of disease and mucosal damage in NEC.…”

Section: In Other Gi Diseasessupporting

confidence: 83%

“…65 These results are consistent with those from OR Herrera, et al recent studies that observed higher FC concentrations in preterm infants with NEC compared to controls 66 and were linked with disease severity. 67 I-FABP may be another marker that correlates well with extent of disease and mucosal damage in NEC. 68,69 Recently, a combination of urinary I-FABP and FC provided a sensitivity of 94%, a specificity of 79%, a positive likelihood ratio of 4.48, and a negative likelihood ratio of 0.08, for diagnosing NEC in a cohort of neonates.…”

Section: In Other Gi Diseasessupporting

confidence: 83%

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Calprotectin: Clinical Applications in Pediatrics

Herrera

Christensen

Helms

2016

The Journal of Pediatric Pharmacology and Therapeutics

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As seen over the past 20 years, calprotectin has evolved as a novel, non-invasive biomarker of gastrointestinal (GI) inflammation. We present this review of calprotectin in pediatrics. This article will focus on studies using calprotectin concentrations from different body fluids to monitor inflammation in different disease states and conditions. The ultimate goal of our group is to lay down a foundation as we consider using calprotectin prospectively as a marker of intestinal inflammation that could lead to further testing and possibly a marker of preparedness for feeding. We surveyed all published studies in English of calprotectin in neonates, infants, children, and adolescents through February 2014. We will discuss calprotectin's basic properties and analysis such as characteristics, identification, presence in body fluids, and maturational development. In addition, calprotectin's use in inflammatory diseases exploring both GI and non-GI conditions will be evaluated and compared with other serum markers presently available. Finally, a summary of our findings and discussion of future work that could be undertaken in order to render calprotectin as a more useful monitoring tool to the medical research community will complete the review.

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Section: In Other Gi Diseasessupporting

confidence: 83%

Section: In Other Gi Diseasessupporting

confidence: 83%

Calprotectin: Clinical Applications in Pediatrics

Herrera

Christensen

Helms

2016

The Journal of Pediatric Pharmacology and Therapeutics

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“…12 Aydemir et al found in their study that the mean GA was 29 weeks, mean birth weight of 950 gm and a mean age of 14 days at diagnosis. 13 In our study, from a total of 500 neonates, 21 preterm showed signs of feeding intolerance. The incidence of feeding intolerance in our study was 4.2%.…”

Section: Discussionmentioning

confidence: 51%

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Islam

Begum²,

Yasmeen³

et al. 2017

Northern Int. Med. Coll. J.

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Background : Premature infants frequently suffer from feeding intolerance and is highly associated to morbidity and mortality. It is a great challenge which have to face all the neonatologist. Feeding intolerance can be defined by difficulty in ingestion or digestion of the milk that causes a disruption in the enteral feeding plan due to the manifestation of some clinical symptoms. These symptoms include gastric residuals, emesis, abdominal distention, visible bowel loops, and change in the character of stool etc.

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“…6 In the first weeks of life, preterm and term infants display a wide range of inter-and intraindividual variation in f-CP levels. 3,8 Infants with necrotizing enterocolitis (NEC) have much higher f-CP levels than healthy infants 3,[9][10][11] and levels are positively correlated with severity of NEC. 9,11 f-CP levels are associated with gastrointestinal distress in preterm infants, with levels higher than 363 lg/g stool as a cutoff for the presence of mild enteropathy.…”

Section: Introductionmentioning

confidence: 99%

“…3,8 Infants with necrotizing enterocolitis (NEC) have much higher f-CP levels than healthy infants 3,[9][10][11] and levels are positively correlated with severity of NEC. 9,11 f-CP levels are associated with gastrointestinal distress in preterm infants, with levels higher than 363 lg/g stool as a cutoff for the presence of mild enteropathy. 12 The presence of f-CP in preterm and term infant stools might be an indication of gut microbiota maturation, as neutrophils migrate to the gut in response to the developing microbial colonization.…”

Section: Introductionmentioning

confidence: 99%

Relationships of Feeding and Mother's Own Milk with Fecal Calprotectin Levels in Preterm Infants

Groër

Ashmeade

Louis‐Jacques

et al. 2016

Breastfeeding Medicine

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Objective: To describe longitudinal effects of feeding volume and type of milk on fecal calprotectin (f-CP) in very low-birth weight (VLBW) infants. Study Design: Prospective data were collected across Neonatal Intensive Care Unit (NICU) admission for 6 weeks or until discharge in 75 VLBW neonates. The mean gestational age on entry into the study was 29 weeks. Results: Seventy-four (99%) mothers provided expressed milk in varying amounts. Twenty-three mothers (31%) provided exclusive mother's own milk (MOM) throughout. Preterm infant formula (PIF) and pasteurized donor milk were added to feedings of remaining infants. Pooled MOM was analyzed weekly for levels of a panel of cytokines, chemokines, and growth factors, and secretory Immunoglobulin A (sIgA) so that the exact amount of exposure to the gut of these milk bioactives could be estimated. f-CP levels ranged from 160 to 350 lg/g stool. Total feeding volume was positively associated with f-CP, controlling for infant weight, and f-CP levels rose across time. Exclusive MOM feedings for the entire measurement period were associated with rising levels of f-CP, but mixed feedings (MOM with added PIF or pasteurized donor milk (PDM) did not show this increase over time. Conclusion:The presence of f-CP may represent a response to milk volumes and MOM, which represents normal development rather than always implicating pathological inflammation in the VLBW infant.

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Fecal calprotectin levels are increased in infants with necrotizing enterocolitis

Abstract: Fecal calprotectin increases in infants with NEC and serial measurements may be useful as a noninvasive prognostic marker for progression of disease.

Cited by 52 publications

References 23 publications

Calprotectin: Clinical Applications in Pediatrics

Calprotectin: Clinical Applications in Pediatrics

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Relationships of Feeding and Mother's Own Milk with Fecal Calprotectin Levels in Preterm Infants

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