Fecal calprotectin in the differential diagnosis of acute intestinal infections

Vlková, Eva; Gospodinova, Margarita; Todorov, Ilia

doi:10.22625/2072-6732-2018-10-2-117-122

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…В то же время понятно, что некоторая часть нерасшифрованных ОКИ может иметь неинфекционный генез, обусловленный, в частности, проявлениями гастроинтестинальной пищевой аллергии, первичного и вторичного ацетонемического синдрома, манифестацией воспалительных заболеваний кишечника и другими причинами [5]. Следует также принимать во внимание, что критерии инфекционной диареи не требуют обязательной верификации этиологии, а учитывают прежде всего клинические признаки острого диарейного синдрома длительностью до 14 дней и наличие одного или нескольких следующих симптомов (боли в животе, тошнота, рвота, тенезмы) в сочетании с интоксикацией и/или эпидемиологическими данными [1,6].…”

Section: Introductionunclassified

Clinical and laboratory features of acute intestinal infections with hyemocolitis syndrome in children

Klimova¹,

Гончар

Алексеева³

et al. 2019

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The acute intestinal infections (AII) with a haemocolitis syndrome represent group of a serious illness at children that defines relevance of studying of their etiology and pathogenesis. The purpose of the work is to study the clinical and laboratory features of AII with hemocolitis syndrome depending on the etiology and complications. Materials and methods. Observed 77 patients of AII aged from 3 months up to 16 years. The etiological diagnosis verified using bacteriological and PCR studies of feces with AmpliSens® OKA screen-FL reagents and serological methods. Hemocolitis syndrome was observed in all patients. Patients with AII of a clarified etiology formed group 1 (n = 59), with AII of unclarified etiology – group 2 (n = 18). Intercurrent diseases were detected as non-specific complications of acute intestinal infections: respiratory (RI) and urinary infections (UI). AII severity was determined by the Clarke-index, the severity of dehydration – according to the WHO clinical scale. To evaluate the data of a research, the Mann-Whitney U-test and Pearson correlation coefficients were used. Results. There was a difference in the age of children in group 1 (3.9 ± 4.2 g) and group 2 (2.2 ± 2.6 g; p = 0.03) and in the frequency of complications: RI is diagnosed in group 1 for 54.5% of children, in group 2 for 83.3% (p=0.001); UI – at 45.5% and 16.7% respectively (p=0.03). In complicated course of AII, macroscopic signs of hemocolitis and inflammatory changes in the hemogram with the inclusion of platelet hemostasis in group 1 observed significantly more often than in group 2. In children of group 1, with uncomplicated acute intestinal infections, there was a significant correlation of signs of inflammation with dehydration and a higher severity of the disease according to the Clarke-index than with a complicated course. Conclusion. The age of children with AII of a clarified etiology was 3.9 ± 0.6 years, with AII of an unclarified etiology – 2.2 ± 0.6 years. AII of a clarified etiology preceded more hard, than AII of unclarified etiology. Complicated course of AII with hemocolitis syndrome characterized by expressiveness of signs of the local and system inflammatory answer.

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Section: Introductionunclassified

Clinical and laboratory features of acute intestinal infections with hyemocolitis syndrome in children

Klimova¹,

Гончар

Алексеева³

et al. 2019

test

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“…Infectious diarrhea continues to be an actual problem of modern medicine -2.7 billion cases are registered globally on an annual basis, of which 1.7 billion have a lethal outcome. The main risk group includes children under 5 years of age, in whom the intestinal infections become the reason for death in 9% of the cases (1).…”

Section: Introductionmentioning

confidence: 99%

Clinical manifestations of mixed infections between rotaviruses and other intestinal pathogens

Vlkova

Gospodinova

Radkova

et al. 2018

SSM

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INTRODUCTION: Rotaviruses are a leading cause of diarrheal mortality in children less than five years old. Mixed forms with other intestinal pathogens have been reported, interfering with the severity and outcome of the illness. AIM: The aim of this article is to analyze the characteristics of mixed infections among rotaviruses and other intestinal pathogens. MATERIALS AND METHODS: Twenty-seven patients up to 5 years of age, diagnosed with a co-infection from the rotavirus group and other intestinal pathogens were analyzed during the period from March, 2016 to December, 2017. A clinical epidemiologic study was conducted. The diagnosis was made by stool cultures for bacterial pathogens/feces analyses for viral antigens in the microbiology/virus laboratory of the St. Marina University Hospital, Varna. Statistic methods were used for data processing. RESULTS: For the aforementioned period, 483 patients, up to 5 years of age, with rotaviral gastroenteritis were hospitalized. Mixed forms of intestinal infection were registered in 27 children (5.59%). Early childhood (between 1 to 3 years of age) was the most commonly affected age group. Cases were separated into two groups: rotavirus-virus association and rotavirus-bacterium association. Cases with rotavirus-virus association were more predominant (55.6%) than rotavirus-bacterium ones (44.4%). The clinical presentation included fever, vomiting, diarrhea, and lasted 6.53±1.53 days among the patients in the first studied group. In rotavirus-bacterium mixed infections vomiting was not a generally present symptom, but distinct complications ordinary occurred (83.33%) and the average hospitalization period was 10±1.98 days. CONCLUSION: Mixed infections including rotavirus and other intestinal pathogens are rarely diagnosed and mainly affect young children. Compared with rotavirus-bacterium association, rotavirus-virus association is more commonly registered, its clinical course is milder, the prognosis of the disease is auspicious and the in-patient stay is shorter.

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Practical Significance of Inflammatory Markers for Infectious Secretary Diarrhea in Children

Bedelbaev

Dzholbunova

Khalupko

et al. 2020

BSP

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In this article, the practical significance of determining markers of inflammation (blood procalcitonin, fecal calprotectin, fecal lactoferrin) for distinguishing infectious secretory from infectious invasive diarrhea, as well as from functional diarrhea of non-infectious genesis, is given in the article. A survey was conducted of 54 children aged 0 to 3 years hospitalized in an infectious disease’s hospital with secretory viral diarrhea (rotavirus, astro-, adeno-, noro-, and enterovirus), for the period 2019–2020.

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Fecal calprotectin in the differential diagnosis of acute intestinal infections

Cited by 4 publications

References 15 publications

Clinical and laboratory features of acute intestinal infections with hyemocolitis syndrome in children

Clinical and laboratory features of acute intestinal infections with hyemocolitis syndrome in children

Clinical manifestations of mixed infections between rotaviruses and other intestinal pathogens

Practical Significance of Inflammatory Markers for Infectious Secretary Diarrhea in Children

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