Fecal Calprotectin in Pediatric Inflammatory Bowel Disease: A Systematic Review

Kostakis, Ioannis D.; Cholidou, Kyriaki; Vaiopoulos, Aristeidis G.; Vlachos, Ioannis S.; Perrea, Despina; Vaos, George

doi:10.1007/s10620-012-2347-5

Cited by 61 publications

(47 citation statements)

References 59 publications

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“…Calprotectin (semi-quantitative and quantitative) tests are recently been used as a routine to rule out a chronic inflammatory process in bowel [22]. There was no significant correlation between the test and calprotectin results in our observation.…”

Section: Discussioncontrasting

confidence: 57%

A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

Nakka¹,

Johansson²,

Shahzad³

et al. 2013

OJGas

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Diarrhea is the most common symptom of acute inflammation in gastrointestinal tract and the patients are isolated in order to inhibit transmission and to conduct investigations. Yet there is no standard test to distinguish gastrointestinal infection from more generalized diseases at admittance which might cause delay in therapy. Hepatocyte growth factor (HGF) is produced upon injury by mesenchymal cells. On the contrary to chronic inflammation, HGF produced in the course of acute inflammation is biologically active and shows binding affinity to heparan sulphate proteoglycan (HSPG) and dextran sulphate (DS). Based on this phenomenon, an agarose gel containing DS was prepared and immobilized on loops to investigate the feces samples for the presence or absence of growth factors such as HGF with affinity to DS. The study is conducted as a clinical evaluation of an experimental model to distinguish acute infectious gastroenteritis from other causes of diarrhea. 656 fecal samples gathered consequently from patients seeking for bowel disturbances and healthy were tested by the test and the medical reports were investigated. Upon interaction with DS, methylene blue changes color to pink. This phenomenon was inhibited by HGF and converted by addition of anti-HGF antibodies to the samples. The test distinguished acute infectious gastroenteritis with high sensitivity and specificity (96% and 92% respectively) from other causes of diarrhea. We introduce a metachromatic experimental model that might distinguish acute inflammation in alimentary tract from other causes of diarrhea. This model might be used in developing rapid diagnostic tests.

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Section: Discussioncontrasting

confidence: 57%

A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

Nakka¹,

Johansson²,

Shahzad³

et al. 2013

OJGas

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“…Kostakis et al 69 reviewed the evidence on FC in PIBD. Few details of methods were given, so the quality score was low.…”

Section: Results Of Clinical Effectiveness Reviewmentioning

confidence: 99%

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

235

201

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“…In younger children, the concentration of calprotectin is physiologically higher [39]. In a Danish cohort, 75 stools samples of healthy infants from 1 month to 4 years old were collected.…”

Section: Values In Healthy Individualsmentioning

confidence: 99%

Fecal calprotectin in inflammatory bowel diseases: update and perspectives

Manceau

Chicha-Cattoir²,

Puy

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Inflammatory bowel diseases (IBDs) are chronic diseases that result from the inflammation of the intestinal wall, suspected in any patient presenting with intestinal symptoms. Until recently, the diagnosis was mainly based on both clinical and endoscopic arguments. The use of an easy, fast, reliable, non-invasive, and inexpensive biological assay is mandatory not only in diagnosis but also in evolutionary and therapeutic monitoring. To date, the fecal calprotectin is the most documented in this perspective. This marker allows the discrimination between functional and organic bowel processes with good performance. The determination of the fecal calprotectin level contributes to the evaluation of the degree of disease activity and to monitoring of therapeutic response.

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Fecal Calprotectin in Pediatric Inflammatory Bowel Disease: A Systematic Review

Cited by 61 publications

References 59 publications

A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Fecal calprotectin in inflammatory bowel diseases: update and perspectives

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