Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women: A preliminary study

Cardinelli, Camila de Siqueira; Torrinhas, Raquel Susana; Sala, Priscila; Pudenzi, Marcos A.; Angolini, Célio Fernando Figueiredo; Silva, Mariane Marques da; Machado, Natasha Mendonça; Ravacci, Graziela Rosa; Eberlin, Marcos N.; Waitzberg, Dan Linetzky

doi:10.1016/j.clnu.2018.12.028

Cited by 19 publications

(13 citation statements)

References 35 publications

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“…Previous studies in humans reported increased levels of circulating bile acids, especially secondary bile acids, after RYGB as measured in blood plasma 25,51,58 . A recent study characterizing bile acids in the fecal samples in women after RYGB showed decreased concentrations of many bile acids 59 ; hence, our results support findings from that study. In rats, RYGB has also been shown to increase plasma bile acid concentrations and the secretion of weight-loss-associated hormones Peptide YY and Glucagon Like Peptide-1 (ref.…”

Section: Rygb Surgery Decreased Fecal Bile Acid Concentrationssupporting

confidence: 92%

Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Ilhan

DiBaise

Dautel

et al. 2020

npj Biofilms Microbiomes

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Although the etiology of obesity is not well-understood, genetic, environmental, and microbiome elements are recognized as contributors to this rising pandemic. It is well documented that Roux-en-Y gastric bypass (RYGB) surgery drastically alters the fecal microbiome, but data are sparse on temporal and spatial microbiome and metabolome changes, especially in human populations. We characterized the structure and function (through metabolites) of the microbial communities in the gut lumen and structure of microbial communities on mucosal surfaces in nine morbidly obese individuals before, 6 months, and 12 months after RYGB surgery. Moreover, using a comprehensive multi-omic approach, we compared this longitudinal cohort to a previously studied cross-sectional cohort (n = 24). In addition to the expected weight reduction and improvement in obesity-related comorbidities after RYGB surgery, we observed that the impact of surgery was much greater on fecal communities in comparison to mucosal ones. The changes in the fecal microbiome were linked to increased concentrations of branched-chain fatty acids and an overall decrease in secondary bile acid concentrations. The microbiome and metabolome data sets for this longitudinal cohort strengthen our understanding of the persistent impact of RYGB on the gut microbiome and its metabolism. Our findings highlight the importance of changes in mucosal and fecal microbiomes after RYGB surgery. The spatial modifications in the microbiome after RYGB surgery corresponded to persistent changes in fecal fermentation and bile acid metabolism, both of which are associated with improved metabolic outcomes.npj Biofilms and Microbiomes (2020) 6:12 ; https://doi.

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Section: Rygb Surgery Decreased Fecal Bile Acid Concentrationssupporting

confidence: 92%

Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Ilhan

DiBaise

Dautel

et al. 2020

npj Biofilms Microbiomes

View full text Add to dashboard Cite

show abstract

“…37 However, while the majority of studies in animal models and patients have shown a surge in plasma BA levels postoperatively, 38,39 others reported no change 40 or even a reduction. 41 Similarly, fecal bile acids have been shown to markedly decrease in patients and rats after RYGB, 6,42,43 raising the question of the role of luminal bile acids in regulating metabolic function. In this study, we showed that BA levels in portal vein were higher compared to peripheral blood in all three groups of animals, with the highest number of disturbed BAs in Sham-BWM, suggesting caloric restriction has a greater impact on BA composition.…”

Section: Discussionmentioning

confidence: 99%

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

et al. 2021

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“…Therefore, the increased hepatic bile acid synthesis also contributes to increased serum bile acids as a complementary mechanism (Scopinaro, 2006; Ferrannini et al, 2015). Compared to BPD, RYGB as well as duodenal-jejunal bypass (DJB, an experimental procedure designed to investigate the mechanism of diabetes remission with no effect on weight-loss), has enough intestinal bile acid reabsorption area, with either decreased (de Siqueira Cardinelli et al, 2019) or unchanged fecal bile acid excretion (Li et al, 2011; Bhutta et al, 2015), and the hepatic bile acid synthesis is decreased (Ferrannini et al, 2015; Zhang et al, 2016), probably due to a feedback regulation in response to the increased serum bile acids.…”

Section: Mechanisms Of Serum Bile Acid Elevation After Bariatric Surgerymentioning

confidence: 99%

Role of Bile Acids in Bariatric Surgery

et al. 2019

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Bariatric surgery has been proved to be effective and sustainable in the long-term weight-loss and remission of metabolic disorders. However, the underlying mechanisms are still far from fully elucidated. After bariatric surgery, the gastrointestinal tract is manipulated, either anatomically or functionally, leading to changed bile acid metabolism. Accumulating evidence has shown that bile acids play a role in metabolic regulation as signaling molecules other than digestive juice. And most of the metabolism-beneficial effects are mediated through nuclear receptor FXR and membrane receptor TGR5, as well as reciprocal influence on gut microbiota. Bile diversion procedure is also performed on animals to recapitulate the benefits of bariatric surgery. It appears that bile acid alteration is an important component of bariatric surgery, and represents a promising target for the management of metabolic disorders.

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Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women: A preliminary study

Cited by 19 publications

References 35 publications

Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

Role of Bile Acids in Bariatric Surgery

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