Febrile Convulsions

Hammill, James F.; Carter, Sidney

doi:10.1056/nejm196603102741007

Cited by 21 publications

(3 citation statements)

References 16 publications

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“…Treatment, usually with phenobarbital, was maintained until 4 or 6 years of age [Hammill and Carter, 1966]. This practice continued until prospective epidemiological studies documented that febrile seizures-particularly in otherwise normal children-rarely lead to temporal lobe epilepsy [Nelson and Ellenberg, 1976;Nelson and Ellenberg, 1978;Annegers et al, 1979;Berg and Shinnar, 1991;Verity and Golding, 1991].…”

Section: Do Seizures Cause Hippocampal Sclerosis and Epilepsy In Humans?mentioning

confidence: 99%

Age-dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Lado

Sankar

Lowenstein

et al. 2000

Ment. Retard. Dev. Disabil. Res. Rev.

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Seizures in the developing brain pose a challenge to the clinician. In addition to the acute effects of the seizure, there are questions regarding the impact of severe or recurrent seizures on the developing brain. Whether provoked seizures cause brain damage, synaptic reorganization, or epilepsy is of paramount importance to patients and physicians. Such questions are especially relevant in the decision to treat or not treat febrile seizures, a common occurrence in childhood. These clinical questions have been addressed using clinical and animal research. The largest prospective studies do not find a causal connection between febrile seizures and later temporal lobe epilepsy. The immature brain seems relatively resistant to the seizure‐induced neuronal loss and new synapse formation seen in the mature brain. Laboratory investigations using a developmental rat model corresponding to human febrile seizures find that even though structural changes do not result from hyperthermic seizures, synaptic function may be chronically altered. The increased understanding of the cellular and synaptic mechanisms of seizure‐induced damage may benefit patients and clinicians in the form of improved therapies to attenuate damage and changes induced by seizures and to prevent the development of epilepsy. MRDD Research Reviews 2000;6:242–252. © 2000 Wiley‐Liss, Inc.

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Section: Do Seizures Cause Hippocampal Sclerosis and Epilepsy In Humans?mentioning

confidence: 99%

Age-dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Lado

Sankar

Lowenstein

et al. 2000

Ment. Retard. Dev. Disabil. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…The belief that seizures could be epileptogenic led to widespread use of anticonvulsants for prevention of febrile seizures, with the goal of reducing seizure recurrence and hippocampal sclerosis that would lead later to the development of epilepsy. Treatment, usually with phenobarbital, was maintained until 4 or 6 years of age [Hammill and Carter, 1966]. This practice continued until prospective epidemiological studies documented that febrile seizures-particularly in otherwise normal children-rarely lead to temporal lobe epilepsy [Nelson and Ellenberg, 1976;Nelson and Ellenberg, 1978;Annegers et al, 1979;Berg and Shinnar, 1991;Verity and Golding, 1991].…”

Section: Do Seizures Cause Hippocampal Sclerosis and Epilepsy In Humans?mentioning

confidence: 99%

Age‐dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Lado

Sankar

Lowenstein

et al. 2000

Ment. Retard. Dev. Disabil. Res. Rev.

View full text Add to dashboard Cite

Seizures in the developing brain pose a challenge to the clinician. In addition to the acute effects of the seizure, there are questions regarding the impact of severe or recurrent seizures on the developing brain. Whether provoked seizures cause brain damage, synaptic reorganization, or epilepsy is of paramount importance to patients and physicians. Such questions are especially relevant in the decision to treat or not treat febrile seizures, a common occurrence in childhood. These clinical questions have been addressed using clinical and animal research. The largest prospective studies do not find a causal connection between febrile seizures and later temporal lobe epilepsy. The immature brain seems relatively resistant to the seizure-induced neuronal loss and new synapse formation seen in the mature brain. Laboratory investigations using a developmental rat model corresponding to human febrile seizures find that even though structural changes do not result from hyperthermic seizures, synaptic function may be chronically altered. The increased understanding of the cellular and synaptic mechanisms of seizure-induced damage may benefit patients and clinicians in the form of improved therapies to attenuate damage and changes induced by seizures and to prevent the development of epilepsy.

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“…He and Hammill 8 have pointed out that facts on which to base a rational approach to this 110 problem are incomplete, and that Unless long-term, randomized, community prospective study and research settle the questions of mechanism significance, prognosis and therapy, continuous prophylactic anticonvulsant therapy after the first febrile seizure is warranted. They feel that waiting for a second seizure to occur before instituting this treatment is an unnecessary risk.…”

Section: Treatmentmentioning

confidence: 99%

Seizures and Fever

Meloff

1971

Postgraduate Medicine

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Febrile Convulsions

Cited by 21 publications

References 16 publications

Age-dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Age-dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Age‐dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization

Seizures and Fever

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