Features of the Vegetative Dysfunction Syndrome in Children With Exacerbation of Bronchial Asthma

Abstract

Aim. The aim of the study was to reveal features of vegetative dysfunction syndrome in children with exacerbation of asthma.Materials and methods. 86 children with asthma of various severity, aged 6 to 18, were examined in this study. All patients underwent a comprehensive clinical and laboratory examination, which included anamnesis collection, physical examination, and laboratory tests, cardiointervalography study at rest and after clinoorthostatic sample. The received cardiointervalograms were processed using the software of the ANKAR-131 and Statistica 12.0 for Windows.Results. Statistically significant increase in heart rate [as well as indicators of the Mo and AMo (p=0.001)] were recorded in patients due to clinoorthostatic sample. Indicators of stress index in children in the period of exacerbation of the disease amounted to 119.36±17.93%/s×s. The vegetative balance was in equilibrium at rest (the index of vegetative equilibrium was within 156.48±21.30%/s), while the shift in the direction of the predominance of the sympathetic department was noted after a minor orthostatic load. The increase of corresponding values of the vegetative index and the adequacy index of the regulatory processes were recorded after the sample (95.56±5.89%/s). Our studies have shown that the more severe the disease, the more significant the changes in patients vegetative parameters.Conclusion. It was established that activation of the sympathetic regulation department and centralization of heart rate