Features of the vaginal microbiota and ways of correction of its disorders in case of full-term pregnancy

Abstract

Introduction. The vaginal microflora has a direct impact on the health of a newborn child, as well as during the postpartum period in new mothers. The composition of the vaginal microflora of a new mother determines the microflora of her conjunctiva, gastrointestinal tract, and the skin of the newborn, which are identical to the microflora of the mother’s birth canal, and the risk of infection in newborns is directly related to the degree of amniotic fluid insemination. At least half of women have some kind of vaginal microcenosis disorder during pregnancy. In the course of the study, the peculiarities of vaginal microbiota in a full-term pregnancy were studied and the effectiveness of correction of vaginal microcenosis abnormalities when applying the preparation Gaynomax was assessed.Aim of the study. To study the peculiarities of the vaginal microbiota in case of full-term pregnancy and to evaluate the effectiveness of correction of its abnormalities when applying the preparation Gaynomax.Materials and methods. On the basis of City Clinical Hospital No. 40, separate subdivision “Maternity hospital“, clinical and diagnostic department 72 pregnant women in the gestation period of 37-39 weeks the analysis of microscopic examination of vaginal swabs culture and sensitivity test was performed. The analysis included the results of a microscopic study of vaginal and cervical swabs stained using the Gram method. Bacteriological analysis of the vaginal content by cultivating aerobic and anaerobic microorganisms on special nutrient media. PCR method with real-time detection of results (Femoflor 16), including the determination of a wide range of microorganisms. To obtain adequate results, only samples with a sufficient number of cells caught in the test tube with the analyzed sample and sufficient total bacterial mass were used. Samples in which the number of DNA of human cells was more than 104 genome equivalents (GE) in the sample were taken into account, this is a swab quality indicator (SQI).The results: In pregnant women with high frequency infectious risk group, vaginal dysbitoic conditions were revealed with development of bacterial vaginosis, vaginal candidiasis and nonspecific vaginitis. Vaginal sanitation was carried out in patients. Excellent effect was obtained in 33/72 (49,2%) women, good effect in 21/72 (31,4%) patients, satisfactory in 13/72 (19,4%), which indicates fully justified expectations from the chosen treatment method. Conclusion: The use of Gaynomax vaginal suppositories is a reasonable and quick method of vaginal sanitation before delivery.